Conserved Protein Domain Family
prolactin_2
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cd10287: prolactin_2 
Vertebrate, non-mammalian prolactin 2 (PRL2)
A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.
Links
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Statistics
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PSSM-Id: 198437
Aligned: 4 rows
Threshold Bit Score: 314.891
Created: 16-May-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative receptor binding interface [polypeptide binding site]
Evidence:
  • Comment:by similarity to other members of this family
  • Citation:PMID 1549776
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  ## ## #  ##  #                     #         #     ##                     
ACQ73167      32 VPDLFDRVIQHSRRMHALSSELFTEFEKYLLpsinhldrspHRCHTARILTPNGKENAQRTPREELTEVILRLLFAWREP 111 ghost shark
ACA13174      42 LADLFDRVIQHSARMHSLSNDLHSEFEQYFLpsknhigkiyRKCHTSSILTPNGKENAQKLAREELTEVILKLLLAWRDP 121 zebrafish
NP_001159384  44 VADLFDRVIRHSGRIHSLSTELEKYLTPRDNelg----rpaRKCHTATMLTPNGKEYAQKITREELTYLILKLLQAWKEP 119 chicken
ACQ73173      34 LADLFDRVIQQSSRMHDVSSDLHWELEQYFLpsrn--iirkRKCHSFGILTPGDKENVQKLEKEQLMEVILRLLGAWEDP 111 spotted green p...

Feature 1                                     #  #  ##  #                                        
ACQ73167     112 LMHFHqnl--hhsKDYSSASHRKAKQMSEMVHELNHGVEILTEKIqlLGEVSNSLRGLWVRDhq-----------gSRAM 178 ghost shark
ACA13174     122 LFQLHqsm--ahqQDFNSFSSNKALEMGDMAHELRKGVEKVAEKMrvLGMLGNSVTGLSAAEamlp------isdsGEAM 193 zebrafish
NP_001159384 120 LSRFNqhi--enlQELPGESLSKAKQISNMVHELETGVEKVTEKMqsMGIISNSLHGMASSEaagls-----isneANVM 192 chicken
ACQ73173     112 LSHLYwsmsqgqdKDFNFYSPGKALEMSDMVQDLRDGVAKVADRMklLGVIRNSAGYTSPEDsgpsaaisfykqghLDPG 191 spotted green p...

Feature 1              #  ##  ## ### ##  #       #
ACQ73167     179 SDYQLLHCFRRDSNKVQNYLKILKCRVLPEPSC 211 ghost shark
ACA13174     194 SDYDLLYCFRRDSNKVQNYLKILKCRIVPEHDC 226 zebrafish
NP_001159384 193 SDSDFIHCFRRDSNKVQSYLKILKCRIMPENSC 225 chicken
ACQ73173     192 DHHDLLHCFKRDSNKVKNYLRILKCTTFPGSDC 224 spotted green pufferfish

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