1F6F,3HHR


Conserved Protein Domain Family
growth_hormone_like
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cd10284: growth_hormone_like 
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Somatotropin/prolactin hormone family
The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.
Links
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Statistics
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PSSM-Id: 198434
Aligned: 5 rows
Threshold Bit Score: 218.905
Created: 4-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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receptor
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding interface [polypeptide binding site]
Evidence:
  • Structure:3HHR: Human growth hormone binds to the extracellular domain of its receptor, contacts at 4 A
  • Citation:PMID 1549776
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #  ## ## #  ##  #                           #         #     ##                  
1F6F_A     21 LFDRATTVANYNSKLAGEMVNRFDEQYGqgins-------eskvINCHTSSITTPnskaEAINTEDKILFKLVISLLHSW 93  sheep
3HHR_A      9 LFDNAMLRAHRLHQLAFDTYQEFEEAYIpkeqkys--flqnpqtSLCFSESIPTPsnreETQQKSNLELLRISLLLIQSW 86  human
BAC15763   34 DLNLAIPIAEFVYHLSSQAYAELQEKPYhgepprvapwsppnvvMSCHPASWQAPskkdEVLHKTDDELLRISLEVLESW 113 sea lamprey
P45640     47 LLDRVIEHAELIYRVSEESCSLYEDMFIplqfq------rnqvgYACITKTLPVPssknEIQQISDKWLLHSVLMLVQSW 120 lumpfish
ACQ73167   35 LFDRVIQHSRRMHALSSELFTEFEKYLLpsinh------ldrspHRCHTARILTPngkeNAQRTPREELTEVILRLLFAW 108 ghost shark

Feature 1                                   #  #  ##  #                                       
1F6F_A     94 DEPLHHAVtelanskgtspallTKAQEIKEKAKVLVDGVEVIQKRIh-----pGEKNEPYPVWSEqssltsqdenVRRVA 168 sheep
3HHR_A     87 LEPVQFLRsvfan----slvygASDSNVYDLLKDLEEGIQTLMGRLedg--spRTGQIFKQTYSKfdtn--shndDALLK 158 human
BAC15763  114 SGVFLRTHa------------iPLAKQLAAMQRLLQDGVATMSEGRkp----aLEFTSVGALPPVde-------sLLRNH 170 sea lamprey
P45640    121 IEPLVYLQtsldrynaapemllNKTKWVSEKLISLEQGVVVLIKKMldegmltINHSEQGLLQNGvqp----qmlESVMR 196 lumpfish
ACQ73167  109 REPLMHFHqnlhhskdyssashRKAKQMSEMVHELNHGVEILTEKIql---lgEVSNSLRGLWVRdh------qgSRAMS 179 ghost shark

Feature 1          #  ##  ## ### ##  #       #
1F6F_A    169 FYRLFHCLHRDSSKIYTYLRILKCRL---TSC 197 sheep
3HHR_A    159 NYGLLYCFRKDMDKVETFLRIVQCRSv-eGSC 189 human
BAC15763  171 RQDLLSCFKNDAHRVVTYLKVIKCRRf--HDC 200 sea lamprey
P45640    197 DYTLLSCFKKDAHKMEAFLKLLKCRQtdrYNC 228 lumpfish
ACQ73167  180 DYQLLHCFRRDSNKVQNYLKILKCRVlpePSC 211 ghost shark

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