1YIQ,1KB0


Conserved Protein Domain Family
PQQ_ADH_II
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cd10279: PQQ_ADH_II 
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PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II)
This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.
Links
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Statistics
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PSSM-Id: 199837
Aligned: 25 rows
Threshold Bit Score: 772.2
Created: 18-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:binding site for calcium and cofactor PQQ (pyrrolo-quinoline quinone)
  • Structure:1YIQ: Quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5 binds PQQ, Ca++, and glycerol, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                #                                    
1YIQ_A     20 GNWMSTGRTYDEQRYSPLKQIsDQNVGQLGLAWSYKLdlDRGVEATPIVVDGVMYTTGPFSVVYALDARDGRLIWKYDPQ 99  Pseudomonas putida
118555     53 ENWLSYGRTYSEQRYSPLDQInRSNVGDLKLLGYYTLdtNRGQEATPLVVDGIMYATTNWSKMEALDAATGKLLWQYDPK 132 Acetobacter (subge...
ABM93839   48 ANWMTHGGTYQEARYSPLDQInTRSIARLKLAWYGDFdtSRGQESTPLVIDGVMYTTSSWSKVYAYDAATGKLLWRHDPK 127 Methylibium petrol...
ABC65006   48 ANWITHGRTYSEQRFSPLSQVnQETVGELGLAWYADMdtARGQEATPLVMDGKLYLTTAWSKVKAFDAATGEPLWEYDPQ 127 Erythrobacter lito...
ABD27306   45 GEWLSYGRDYGEQRFSPLTQInDGNVGQLGLAWFHDLetARGQEATPLMHDGTLYISTAWSMVKAFDAKTGALKWSYDPE 124 Novosphingobium ar...
ABI75543   41 NEWLTYGGTYDEQRHSKLTAInKENVGELGVAWTYDLatNRGVESTPIVVDGVMYVTSAWSVVYALDAKTGEEKWVYDPG 120 Hyphomonas neptuni...
ABF52102   52 DDWGAIGFSYDEQRFSPLTDInDRNVGDLGIAWFADLedARGQEATPVVVDGVMYVSHAWSKVSAWDAATGKPLWKYDPK 131 Sphingopyxis alask...
ABM93867   49 ANWLAYGRNYSEQRYSPLAQVhAGNVGRLGLAWSMALpeDRSLLSTPLIVDGVMYFTGSWSKTRAVDAATGKLLWEYDPE 128 Methylibium petrol...
ABQ70500   32 VQWEYRGGNAEGQHFSPLEQIdEQSIGRLGLAWYADIpsPDGPVGTPIVVDGVSYVISTLNIVYAHDLRTGKLLWAFDPK 111 Sphingomonas witti...
AEA84895   43 ADWLAYGRTHSEQRFSPLKDInVDNVSQLKPEWYAPLpdRSDMVGTPLVVDGVMYYVGEMNRTRAFDARTGKKLWEYDPQ 122 Pseudomonas stutze...

Feature 1                 ##  # #                                                 #           
1YIQ_A    100 SDRHRA---GEACCDAVNRGVAVWKGKVYVGVLDgRLEAIDAKTGQRAWSVDTRADHKr-----sYTITGAPRVVNGKVV 171 Pseudomonas putida
118555    133 VPGNIA---DKGCCDTVNRGAGYWNGKVFWGTFDgRLVAADAKTGKKVWAVNTIPADAslgkqrsYTVDGAVRVAKGLVL 209 Acetobacter (subge...
ABM93839  128 VPGDRG---ADACCDVVNRGVAAWNGKVYVGTLDgRLEALDAKTGKLVWSTVTVDQTRp------YTITGAPRVVKGKVL 198 Methylibium petrol...
ABC65006  128 VPGETA---VKACCDVVNRGLAAWNDKLYLGTLDgRLVALDRDTGEVAWEKVTVDQSKa------YTVTGAPRIIDGKVL 198 Erythrobacter lito...
ABD27306  125 VPRETL---VRACCDAVNRGVALYGDKVFVGTLDgRLVALDQKTGKVVWSKVVVPNQEd------YTITGAPRVVKGKVL 195 Novosphingobium ar...
ABI75543  121 ADRAVG---VKACCDVVNRGVAVYDGKVYVGVIDgRLEALNAETGEVIWSKVTVDQEKp------YTITGAPRVVNGKVL 191 Hyphomonas neptuni...
ABF52102  132 VPGERA---VHACCDVVNRGVAVWGDKVFVGALDgRLIALDRTSGKELWATQTFDADRp------YTITGAPRVVKDMVL 202 Sphingopyxis alask...
ABM93867  129 SIKHAGg-eRLRAMWDSSRGLAYWKGKLVIATIDgRLIGLDAKTGQKLWSTQTFDPKRp------LYISGHPKAFRDLVI 201 Methylibium petrol...
ABQ70500  112 VRFGSAl--LASWGNRITRGLGYGNGKIVLTTGDcRVIAIDARTAAKQWEARACPDQGd------YTITSAPRVGGGKVF 183 Sphingomonas witti...
AEA84895  123 VSKEILdnnMKKVFWKHNRGLSTYGDKLFIATWDgRLIAINRKDGKEVWQTRTFDHDQp------LNITGHPKAFDGKVF 196 Pseudomonas stutze...

Feature 1        ####                                                              # #        
1YIQ_A    172 IGNGGAEFG-VRGYVTAYDAETGKEAWRFYTVPGDPKLPPEgkgm-----eiaAKTWFGDAYVEQGGGGTAWDSFAYDPE 245 Pseudomonas putida
118555    210 IGNGGAEFG-ARGFVSAFDAETGKLKWRFYTVPNNKNEPDHaasdnilmnkayKTWGPKGAWVRQGGGGTVWDSLVYDPV 288 Acetobacter (subge...
ABM93839  199 IGNGGAEYG-VRGYVSAYDAETGALAWRFYMTPNPENKPDGaasdai-lmskaYGTWHDGAWKQTGGGGTPWDAIVYDTD 276 Methylibium petrol...
ABC65006  199 IGNGGAEFG-VRGYIAAYDAADGEELWRFYTVPEGTEDESSpaylq--eaaatWNTDVLASSDAIGGGGTVWDSMAYDPE 275 Erythrobacter lito...
ABD27306  196 IGSGGSEYK-ARGYIAAYDVNTGNEVWKFHTVPGNPADGFEnka------menAARTWAGEWWKLGGGGTVWDSITYDPA 268 Novosphingobium ar...
ABI75543  192 IGNGGAELG-VRGYLSAYDTSSGDLVWRFYTVPNPKKQPDGaasddafvqvgnVTWGDEGAWTTDGGGGTVWDSIVYDEV 270 Hyphomonas neptuni...
ABF52102  203 IGNGGAEFG-VRGYVTAYDADTGRQRWRFYTAPNPKKAKDGaasdaifaskgnATWSDTGEWQTSGGGGTVWDAIVYDKD 281 Sphingopyxis alask...
ABM93867  202 VGNGGSEFGaGRGFVSAYHVDSGKLAWKFYVVPGNPADGFEdea------qamAAKTWTGEWWKHGGGGQVWNGLTYDPE 275 Methylibium petrol...
ABQ70500  184 VGPNNADLGtARGYVVAFDLETGNRLWRFDTIPDGPDPTDPtm--------kmAAKTWDPVFLRTAAGGSVWEDMTYDPV 255 Sphingomonas witti...
AEA84895  197 VGNGGTELGpMRGYVTAYDAETGKQVWRFYIVPGNPADGFEdaa------qemAAKTWSGRWWENGGGGNAWHGWTYDAK 270 Pseudomonas stutze...

Feature 1              #   #                                             # #                  
1YIQ_A    246 LNLLYIGVGNGSLWDPKWRSQa-----KGDNLFLSSIVAVNADTGEYVWHYQTTPGDAWDYTATQHMILAELPI--DGKP 318 Pseudomonas putida
118555    289 SDLIYLAVGNGSPWNYKYRSEg-----IGSNLFLGSIVALKPETGEYVWHFQATPMDQWDYTSVQQIMTLDMPV--KGEM 361 Acetobacter (subge...
ABM93839  277 FDQVIIGTGNGNPWSWEHRSGs-----KGDNLFLGSLLALDAETGAYKWHYQETPSENWDFTSTQPIILTELTL--QGRQ 349 Methylibium petrol...
ABC65006  276 LDLLYIGVGNGSPWNRAYRSPgadgtgEGDNLYLSSIVAIRPDTGEYVWHYQTTPGETWDYTATQHIILADLEI--DGRE 353 Erythrobacter lito...
ABD27306  269 TNLVLFGTGNAEPWNPAAAGR------EGDSLYTSSIVAVNADTGDYVWHFQETPEDRWDFDSAQQITLADLTI--DGQR 340 Novosphingobium ar...
ABI75543  271 NNQIIFGVGNGSPWNRTFRDPs-----AGDNLFLSSIVAVDLETGAYKWHFQTTPGDNWDYTATQTIILADLPLgeNGAS 345 Hyphomonas neptuni...
ABF52102  282 LDQIYLGVGNGNPWNHGTRSNg-----EGDNWFLSSIVALDATTGAYKWHYQETPAETWDYTATQPIILAEQAV--NGTP 354 Sphingopyxis alask...
ABM93867  276 YDQILIGTGNGGPWNRKVRSPd-----GGDNLFLCSIVALDARTGKYKWHYQTVPGETWDYNSSMDMVLADLKLrpGGGP 350 Methylibium petrol...
ABQ70500  256 TRLLYIGVGGATPWNPMNRGAr-----RGDELFTNSIVAVKADTGEYVWHYQTTPDDGWNLEPTMPMVIADMEI--DGRK 328 Sphingomonas witti...
AEA84895  271 YNQLIFGTGNGGPWNIKVRSPe-----GGDNLFLCSVVAVDADTGEYKWHVQTAPGDTWDYNSNMDIVLADLKI--DGKD 343 Pseudomonas stutze...

Feature 1             #                                                           ##   ##     
1YIQ_A    319 RKVLMQAPKNGFFYVIDR-ATGELLSAKGIVPQSWTKGMDm-kTGRPILDeENAAYwkngkrnlvtPAFWGAHDWQPMSY 396 Pseudomonas putida
118555    362 RHVIVHAPKNGFFYVLDA-KTGEFLSGKNYVYQNWANGLDp-lTGRPMYN-PDGLYtlngkfwygiPGPLGAHNFMAMAY 438 Acetobacter (subge...
ABM93839  350 RKALLHAPKNGFFYVVDR-KDGALISAEPFTTVNWATGIDl-kTGRPIEA-PGARYertkksfwamPGPFGSHNWHPMAF 426 Methylibium petrol...
ABC65006  354 RQVLMQAPKNGFFYVIDR-ATGEFISAEEYIPQNWAEGIDe--NGRPIEV-AEARIdktgepalvmPGPLGGHNWHPMAF 429 Erythrobacter lito...
ABD27306  341 RHVILHAPKNGHVYVLDA-RTGQFLSATPFVMVNWATGIDp-kTGKATVN-PEARYektgkpfvslPGAVGAHSWQPQSF 417 Novosphingobium ar...
ABI75543  346 RRVAMQAPKNGFFYVIDA-ATGEYISGDAYVPTNWATGLDe--NGRPIEV-PEARYtkqp--feqtPGPLGGHNWHPMAF 419 Hyphomonas neptuni...
ABF52102  355 TKVLYHAPKNGFFFTIDR-ATGKLLDAKPFVDGINWASGYdlaTGRPIEN-PEARFyrtgkpfiaiPGALGAHNWHPMSY 432 Sphingopyxis alask...
ABM93867  351 RKVLLHAPKNGFFYVIDR-KNGKLLSAEKIAKVTWATGIDm-kTGRPIEA-EGARYedgs--elvwPSVYGAHNWHAMSF 425 Methylibium petrol...
ABQ70500  329 RRVVMEAPKNGFFYVLDAlDGTLVNKPNNFVPVNWAKEIDg-rTGRPVMN-PEAEYwkkdggavvfPGPLGAHNFNPMSY 406 Sphingomonas witti...
AEA84895  344 VDAVLHAPKNGFFYTIDR-SNGKVLSAEKFADANWSTRYDl-kEQRHIVA-DDARYpdge--kniyPSAFGAHSWHAMSY 418 Pseudomonas stutze...

Feature 1                                           #                                         
1YIQ_A    397 NPDTGLVYIPAHIMSAYYEHIPe---APKRNpf--ksMYQLGLRTGmmpegaegl---lemakswsGKLIAWDPVKQQAA 468 Pseudomonas putida
118555    439 SPKTHLVYIPAHQIPFGYKNQVg---GFKPHa----dSWNVGLDMTknglpdtpea-rtayikdlhGWLLAWDPVKMETV 510 Acetobacter (subge...
ABM93839  427 SPKTGLTYIPVQDVPLDYNYSP----DFKYSpq--rgTWNTGIEATtfagpgsesh-rrllamqtrGALVAWDAVRQKEA 499 Methylibium petrol...
ABC65006  430 HPGEGLVYIPAFEAATIYDPEP----DWKPDpa---rGFNVGFNLGagdlppdmgi-rkqvygtvkGKLMAWDPVAQEAR 501 Erythrobacter lito...
ABD27306  418 SPKTGLLYLPVNNAAFPYAAAK----DWKATd----iGFQTGLDGYvtsmpadakv-qgaamkattGTLVAWDPVAKKAA 488 Novosphingobium ar...
ABI75543  420 NPDEGLAYIPAQEIPQAYAEDS----RFTARp----vSWNTGIDFSagvppiappdvakflraslkGRLIAWDPIARAPR 491 Hyphomonas neptuni...
ABF52102  433 NPATGLVYIPAQQIPQAYVADMne-lDRRKVv-----GFNVGTSLTgtmlpddkaa-yraavaattGRLVAFDPRTGKVA 505 Sphingopyxis alask...
ABM93867  426 NPKTGLVYIPKVELPALFTDTGvrivDWRKPenfgqlDVAVDIGLGsdipk-----------dagvSSLLAWDPVKQKKA 494 Methylibium petrol...
ABQ70500  407 DPGTGLVYIPTLDLPTQMEIDKt--aSVGSSv-----GGATYTRYLshmd-------------qakWPLVAWDPIRQKAR 466 Sphingomonas witti...
AEA84895  419 NPELNLAFIPTNHLGNTFKDDGkn-tKPGHKma--shKLYLGLTGWeltkd----------phesrGSLQAWDPVKNKRV 485 Pseudomonas stutze...

Feature 1             #                                                               ##      
1YIQ_A    469 WEVPYVTIFNGGTLSTaGNLVFEGSADGRVIAYAADTGEKLWEQPAASGVMAAPVTYSVDGEQYVTFMAGWGGAFSTFag 548 Pseudomonas putida
118555    511 WKIDHKGPWNGGILATgGDLLFQGLANGEFHAYDATNGSDLYKFDAQSGIIAPPMTYSVNGKQYVAVEVGWGGIYPISmg 590 Acetobacter (subge...
ABM93839  500 WRVQHGNLASAGVLATgGNLVFQGTPDGRLVAYTADTGRQVWSWQGFDGIIAGAMTYAVGGEQYVAVVAGFGGSNALHap 579 Methylibium petrol...
ABC65006  502 WTVEFPGPWNGGILATgGGLVFQGNSGSEFAAYDASTGEKLWGFPAQTGIVAPPITYTVDGEQFVAVLAGWGGAYAITad 581 Erythrobacter lito...
ABD27306  489 WKVELPSPSNGGILSTaGNLVFQGTAGGDFVAYNADKGKQLWSFPAQSGILAAPMTYAIDGEQYVAVMVGWGGVWDVAtg 568 Novosphingobium ar...
ABI75543  492 WSVEHENAWNGGVLSTaGGVVFQGKLGGEFVAYDAATGDKLWSHELKSGGASGPGTFMIDGEQYVTITTGWGSAFALAag 571 Hyphomonas neptuni...
ABF52102  506 WGVDHPAAWNGGTMTTaGNLVFQGTSTGRFRAYAADTGKQLLDLDMQSGIVGAPSTFRVNGVQYVAFQTSKGGAFPLVag 585 Sphingopyxis alask...
ABM93867  495 WEVAQPNYWNPGTMTTaGNLVFQGRIDGTFIAYDARDGRQLWSVHVGSGISAPPVTYSVGGRQYVSLLVGWGGAGMSLgg 574 Methylibium petrol...
ABQ70500  467 WQTAGTIPLGSGVLSTaGNIVFQGGADGVLRAYRASDGVQLWSFKTGSAIAAAPVTVDIDGVQTLIVVAGPPGTSAAVra 546 Sphingomonas witti...
AEA84895  486 WRVNQKSPWGGGTLTTaGNLVFQGEPDGLFKAYDARTGQELWSYDVGLGISAPPITYKLDGKQMVSLLVGPGGALASNfg 565 Pseudomonas stutze...

Feature 1                                      
1YIQ_A    549 als-------lragVQPYAQVLTYKLGGTAKLQ 574 Pseudomonas putida
118555    591 gvg------rtsgwTVNHSYIAAFSLDGKAKLP 617 Acetobacter (subgen. Acetobacter) aceti
ABM93839  580 fa--------vapkVGLHGRILAFKLDGRAVLP 604 Methylibium petroleiphilum PM1
ABC65006  582 gelv-----ndqgpVQNISRLLVFKIGGTGELP 609 Erythrobacter litoralis HTCC2594
ABD27306  569 vla------hkakkQRNISRLVVFKLGGKATLP 595 Novosphingobium aromaticivorans DSM 12444
ABI75543  572 fay-------dekvESTVGKVVTFKLGATGEIA 597 Hyphomonas neptunium ATCC 15444
ABF52102  586 vag------gatrkVPNIPRLVVLKLGGRAQLP 612 Sphingopyxis alaskensis RB2256
ABM93867  575 gssma---qygwgfGGQTRQLLTFALDGKLPMP 604 Methylibium petroleiphilum PM1
ABQ70500  547 fpgl-----ygradTNGPPRIFAFRLDARAAAP 574 Sphingomonas wittichii RW1
AEA84895  566 gsgelgfeshgwkyGTHERRIMTFSLDGKAVVP 598 Pseudomonas stutzeri DSM 4166

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