2H8N


Conserved Protein Domain Family
ClassIIa_HDAC4_Gln-rich-N
?
cd10162: ClassIIa_HDAC4_Gln-rich-N 
Click on image for an interactive view with Cn3D
Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
This family consists of the glutamine-rich domain of histone deacetylase 4 (HDAC4). It belongs to a superfamily that consists of the glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDCA9; it is missing from HDAC7. This domain confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors, and it is able to repress transcription independently of the HDAC C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.
Links
?
Statistics
?
PSSM-Id: 197398
Aligned: 4 rows
Threshold Bit Score: 77.16
Created: 26-Apr-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:four copies of HDAC4 form a four-helix bundle
  • Comment:The interactions of each helix with its neighboring three helices are the same for all four helices due to the D2 point group symmetry.
  • Structure:2H8N: human histone deacetylase 4 (HDAC4) glutamine-rich region, tetramer interface; contacts at 4.0A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          ## ##  #   #  ##  ## ##  ## ##  ### ### ## ### ##  #  ##  ###                  
2H8N_A         22 EPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKqQQEMLAMKHQQELLEHQRKLERHRQEQE 101  human
NP_001034447   33 DPAQREHQLQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKhQQDLLALKHQQELLEHQRKLGRHRQEQE 112  zebrafish
NP_989644      63 EPTLREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIK-QQEMLAMKHQQELLEHQRKLEQHRQEQE 141  chicken
XP_002932071   82 EPGGREQQLQQELLALKQKQQIQRQLLIAEFQRQHEQLSRQHEAQLHEHIKqQQELLAMKHQQELLEHQRKLEQHRQEQE 161  western clawe...

Feature 1                   
2H8N_A        102 LEKQHREQKL 111  human
NP_001034447  113 MEKQQREQKL 122  zebrafish
NP_989644     142 LEKQHREQKL 151  chicken
XP_002932071  162 MEKQQREQKL 171  western clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap