Conserved Protein Domain Family
HDAC9
?
cd10009: HDAC9 
Histone deacetylase 9
Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. Its deregulated expression may be associated with some human cancers. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.
Links
?
Statistics
?
PSSM-Id: 212533
Aligned: 3 rows
Threshold Bit Score: 788.828
Created: 30-Dec-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1:putative active site [active site]
Evidence:
  • Comment:Active center contains inhibitor and a catalytic Zn ion that coordinates side chain atoms of two aspartates and one histidine, and a water molecule.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
Q9UKV0        631 SATGIAYDPLMLKHQCVCGNsttHPEHAGRIQSIWSRLQETGLLnKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLdGQ 710  human
NP_001026152  632 YTTGVVYDSLMLKHQCMCGNyanHPEHAGRIQSIWSRLQETGLLnKCERIRGRKASLEEIQLVHSEHHSLLYGTSPLnRQ 711  chicken
EHH52288      634 SATGIAYDPLMLKHQCVCGNsttHPEHAGRIQSIWSRLQETGLLnKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLdGQ 713  crab-eating m...

Feature 1                                                                                ##       
Q9UKV0        711 KLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASgELKNGFAVVRPPGHHAEESTAM 790  human
NP_001026152  712 KLDPRKLLGNVSQKLFSLLPCGGLGVDSDTVWNELHSAGAARMAVGCVIELAARVASrELKNGFAVVRPPGHHAEESTAM 791  chicken
EHH52288      714 KLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASgELKNGFAVVRPPGHHAEESTAM 793  crab-eating m...

Feature 1         ##                           # #                                                
Q9UKV0        791 GFCFFNSVAITAKYLRDqlnisKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNI 870  human
NP_001026152  792 GFCFFNSIAITAKYLRDklnigKILIVDLDVHHGNGTQQAFYADPSILYVSLHRYDEGNFFPGSGAPNEVGSGPGEGFNI 871  chicken
EHH52288      794 GFCFFNSVAITAKYLRDqlnisKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNI 873  crab-eating m...

Feature 1                                                    #                                    
Q9UKV0        871 NIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHtPPLGGYKVTAKCFGHLTKQLMtLADGRVVL 950  human
NP_001026152  872 NIAWTGGLDPPMGDVEYLTAFRTVIMPAANEFDPEIVLVSAGFDAVEGHdPPLGGYKVTAKCFGHLTKQLLkLADGRVVL 951  chicken
EHH52288      874 NIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHtPPLGGYKVTAKCFGHLTKQLMtLADGRVVL 953  crab-eating m...

Feature 1            #                                                       
Q9UKV0        951 ALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLK 1009 human
NP_001026152  952 ALEGGHDLTAICDASEACINALLGNELEPLPEDIVHQIPNMNAIASLKKTTEIQSKYWK 1010 chicken
EHH52288      954 ALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWK 1012 crab-eating macaque

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap