Conserved Protein Domain Family
HDAC5
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cd10007: HDAC5 
Histone deacetylase 5
Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression; cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, possibly by blocking drug-stimulated gene expression that supports drug-induced behavioral change. It is also involved in regulation of angiogenesis and cell cycle as well as immune system development. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.
Links
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Statistics
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PSSM-Id: 212531
Aligned: 4 rows
Threshold Bit Score: 890.106
Created: 30-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative active site [active site]
Evidence:
  • Comment:Active center contains inhibitor and a catalytic Zn ion that coordinates side chain atoms of two aspartates and one histidine, and a water molecule.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
XP_685659     675 HLFTTGLVYDTFMLKHQCMCGNTniHPEHAGRIQSVWSRLQETGLLgRCERIRGRKATLDEIQTVHSEYHTLLYGTSPln 754  zebrafish
Q9UQL6        679 HLFTTGVVYDTFMLKHQCMCGNThvHPEHAGRIQSIWSRLQETGLLsKCERIRGRKATLDEIQTVHSEYHTLLYGTSPln 758  human
XP_003222695  702 HLFTTGVVYDTFMLKHQCTCGNTnvHPEHAGRIQSIWSRLQETGLLsKCERVRGRKATLDEIQTVHSEHHTLLYGTSPln 781  green anole
XP_002935586  633 VISTTGLVYDTLMLKHQCTCGDTnnHPEHAGRIQSVWSRLQETGLLgKCQRVRGRKATLDEIQTVHTEHHTLLYGTSPqs 712  western clawe...

Feature 1                                                                                  ##     
XP_685659     755 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSGAVRMAVGCVIELAFKVAAGELKNGFAVVRPPGHHAEEST 834  zebrafish
Q9UQL6        759 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEEST 838  human
XP_003222695  782 RQKLDSKKLLGPLTQKMYTVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLVELAFKVASGELKNGFAVIRPPGHHAEEST 861  green anole
XP_002935586  713 RHKLESKNILGTLSQKLYAVLPCGGIGVDSDTVWNELHSPPAVRTAVGSLIELVYKVAAGELKNGFAVIRPPGHHAEESV 792  western clawe...

Feature 1           ##                           # #                                              
XP_685659     835 AMGFCFFNSVAITAKLLQQKlgVGKILIIDWDIHHGNGTQQAFYNDPnVLYISLHRYDDGNFFPGSGAPEEVGVGPGEGF 914  zebrafish
Q9UQL6        839 AMGFCFFNSVAITAKLLQQKlnVGKVLIVDWDIHHGNGTQQAFYNDPsVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGY 918  human
XP_003222695  862 AMGFCFFNSVAIAAKLLQQKlaISKILVVDWDIHHGNGTQQAFYSDPnVLYISLHRYDNGNFFPGSGAPDEVGSGMGVGY 941  green anole
XP_002935586  793 AMGFCFFNSVAIAAKLLRQKmnVGRILIVDWDIHHGNGTQQAFYNDPnILYISLHRYDDGNFFPGSGSSDEVGAGHGTGF 872  western clawe...

Feature 1                                                      #                                  
XP_685659     915 NVNIAWTGGVEPPmGDVEYLTAFRTVVMPIANEFSPDVVLVSAGFDAVEGHqSPLGGYNVTAKCFGHLTKQLMkLAGGRV 994  zebrafish
Q9UQL6        919 NVNVAWTGGVDPPiGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHlSPLGGYSVTARCFGHLTRQLMtLAGGRV 998  human
XP_003222695  942 NVNIAWTGGVDPPiGDVEYLTAFRTVVMPIANEFSPDVVLISAGFDAVEGHlSPLGGYSVTAKCFGHLTKQLMeLAGGRV 1021 green anole
XP_002935586  873 NVNIAWTGGVDPPvGDAEYLAAFRMVVMPVAKEFSPDFVLVSAGFDAVEGHqSPLGGYSVTAKCFGHLTKQLMtLAGGQV 952  western clawe...

Feature 1              #                                                                          
XP_685659     995 VLALEGGHDLTAICDASESCVEALLGDELNPLpltVLQQKPCPKATASLERVIEIQSKHWTSLQrlaptVGQSLLDAQRR 1074 zebrafish
Q9UQL6        999 VLALEGGHDLTAICDASEACVSALLSVELQPLdeaVLQQKPNINAVATLEKVIEIQSKHWSCVQkfaagLGRSLREAQAG 1078 human
XP_003222695 1022 VLALEGGHDLTAICDASEACVSALLGLELEQLdqtLLQQKPNANAVATLENVIEIQSKHWNSLKrfaalVGCSLLEAQKG 1101 green anole
XP_002935586  953 VLALEGGHDLTAICDASEACVSALLGMEPTPFdnsVLQQRPSDNAIATLERVINIHGKHWSCLKss--tLGFSILEAQRV 1030 western clawe...

Feature 1                             
XP_685659    1075 EKDEADtLTAMASLTVDNEQ 1094 zebrafish
Q9UQL6       1079 ETEEAEtVSAMALLSVGAEQ 1098 human
XP_003222695 1102 EAEEAEtVSAMASLSVDTEQ 1121 green anole
XP_002935586 1031 ELEEAEaVSALASLSVDTDQ 1050 western clawed frog

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