Conserved Protein Domain Family
HDAC6-dom2

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cd10003: HDAC6-dom2 
Histone deacetylase 6, domain 2
Histone deacetylase 6 is a class IIb Zn-dependent enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).
Statistics
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PSSM-Id: 212527
Aligned: 10 rows
Threshold Bit Score: 643.237
Created: 30-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activeZn binding site
Feature 1:putative active site [active site]
Evidence:
  • Comment:Active center contains inhibitor and a catalytic Zn ion that coordinates side chain atoms of two aspartates and one histidine, and a water molecule.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
Q9UBN7        485 YDQNMMNHCNLWDs---------hHPEVPQRILRIMCRLEELGLAGRCltltpRPATEAELLTCHSAEYVGHLRatekMK 555  human
Q8IR37        548 YDAQMLLHCNLNDt---------gHPEQPSRIQHIHKMHDDYGLLKQMkqlspRAATTDEVCLAHTRAHVNTVRrllgRE 618  fruit fly
NP_001080486  486 YDEQMMEHRNMWDc---------yHPESPQRINQIFKRHKDLGLLERCsrlpsRLATQKELQMCHSLSYIQKIEasahMK 556  African clawe...
AAI15263      296 YDQRMMLHHNMWDs---------hHPELPQRISRIFSRHEELRLLSRChripaRLATEEELALCHSSKHISIIKssehMK 366  zebrafish
EEN43587      473 HDEAMMNHVNIWMp---------gHPEQPYRIRRIMQALDRHRLQDRCvklesRLATEEELLYLHTAEHLQLMQetaeMT 543  Florida lancelet
EHJ64741      498 YDPAMLKHHNVCEp---------gHVECPERIMRIHERHRDFGLLERVhrlppRSAADDEILAVHTEKYLDSLKelssTK 568  monarch butte...
EDO33321        5 YDDRMKRHVNIWDkyvyintlicsLYEVPDRIGRPYEKHKEYGLLDRCykipsRHATEEDLLCLHSKEHIDKMKstqdMK 84   starlet sea a...
XP_002164574   31 YDQKMCEYFNLEDk---------nHVERPARISSIYNALNKNGLTCRCqilksRFASHDEILLKHNEHHLKVIEslstKT 101  green hydra
XP_001942623  474 FDLIMDQKHESSEs---------gHPECPGRISAILNMYNEFQLTHRLlilpsREAEESELLLAHSREHVDEMSnlhkLS 544  pea aphid
XP_003382755   43 YDERMKNHRNDNNp---------nHPECPERISSIWEQLVDDGVVECCrridaRSATEQEILYVHSKTHYDEMVatenMS 113  Amphimedon qu...
Feature 1                                                                     ##       ##         
Q9UBN7        556 TRELHRESSNFDSIYIcpstfACAQLATGAACRLVEAVLSGev------lnGAAVVRPPGHHAEqdaACGFCFFNSVAVA 629  human
Q8IR37        619 PKELHDAAGIYNSVYLhprtfDCATLAAGLVLQAVDSVLRGes------rsGICNVRPPGHHAEqdhPHGFCIFNNVAIA 692  fruit fly
NP_001080486  557 PRDLHRLGDEYNSIYInsksyHSARLAAGSTFNVVEAVVTGka------qnGIGIVRPPGHHAEpgeACGFCFFNTVALA 630  African clawe...
AAI15263      367 PRDLNRLGDEYNSIFIsnesyTCALLAAGSCFNSAQAILTGqv------rnAVAIVRPPGHHAEkdtACGFCFFNTAALT 440  zebrafish
EEN43587      544 PRQLNRTQADFNSIFLcndtyKSACLAAGCSMNAVEAVATGsv------rsAVAVVRPPGHHAEvdkPCGFCIFNSAALA 617  Florida lancelet
EHJ64741      569 LRDLNAQRKSFDSVYFhpdslQSAAAAAGAVIQMVDAVLRHgs-------gGVCVVRPPGHHADedvPSGFCLLNNVAVG 641  monarch butte...
EDO33321       85 PRDLFNLGEEYDSIYMskdvyDCALLSCGCTLAAVEHVATNksskhsihinQLFFLRPPGHHADadsAMGYCFFNNVAIA 164  starlet sea a...
XP_002164574  102 DEELGKMSCDYDSIYFhpnssESSFLSVGCTLEVVEQVLKKni------lnGVAIVRPPGHHALthcSMGFCHFNNVAIA 175  green hydra
XP_001942623  545 PSELSEKEKCYDSVYLttdtyKVSTLASGCLLQVVDSVMKNes------asGVAVIRPPGHHAEldiACGFCIFNSVAIA 618  pea aphid
XP_003382755  114 LEKLFQRALRLNSIYInpssmQCALLAAGSVCEVTKLVIDEtv------dnGVAIVRPPGHHAEsytSMGFCFFNNVAIA 187  Amphimedon qu...
Feature 1                               # #                                                       
Q9UBN7        630 ARHAqtis---ghalRILIVDWDVHHGNGTQHMFEDDpsVLYVSLHRYDHGTFFPMgDEGASSQIGRAAGTGFTVNVAWN 706  human
Q8IR37        693 AQYAirdf----gleRVLIVDWDVHHGNGTQHIFESNpkVLYISLHRYEHGSFFPKgPDGNFDVVGKGAGRGFNVNIPWN 768  fruit fly
NP_001080486  631 ARYAqrlqsqsedplRVMILDWDVHHGNGTQHIFQEDasVLYMSLHRYDEGLFFPNsEDASHDKVGIGKGAGYNVNIPWN 710  African clawe...
AAI15263      441 ARYAqsit---reslRVLIVDWDVHHGNGTQHIFEEDdsVLYISLHRYEDGAFFPNsEDANYDKVGLGKGRGYNVNIPWN 517  zebrafish
EEN43587      618 ARFAqkrl----gvgRVLILDWDIHHGNGTQHMFVDDptVLYISIHRYDNGMFFPGsPDADCTVVGSGPGEGFTVNVPWS 693  Florida lancelet
EHJ64741      642 ARHAraah----gltRIMILDWDVHHGNGTQRITYEDkeILYISIHRYDNGSFFPNsPAADHTAVGQGRGEGYNINIPWN 717  monarch butte...
EDO33321      165 AKLAqqrw----gmqRILIVDWDIHHGNGTQNLFESDpsVLYFSLHRYDHANFYPFsAQANYDIVGKGQGKGFNVNVPWN 240  starlet sea a...
XP_002164574  176 AEYAvkky----glkRVLIVDWDIHFGNGIHKMFENDnyVLYFSMHRYDNQRFWPClAEGNYNSIGKGDGEGFNVNVAWN 251  green hydra
XP_001942623  619 ASYAlnky----glkRIMILDWDIHFGNGTMRAFSSDprVLYISIHRYQNAKFFPCsEEGSHKVTGSGSGEGYTINIPWN 694  pea aphid
XP_003382755  188 AKMAieey----gvkRILIIDWDVHHGNATQHMFYDDnrVLYVSLHRHDNGGFYPGgDEGDYDKVGKGKGSGYNVNIPWN 263  Amphimedon qu...
Feature 1                                            #                                     #      
Q9UBN7        707 gprMGDADYLAAWHRLVLPIAYEFnPELVLVSAGFDAARGDPLGGcQVSPEGYAHLTHLLMGLAsGRIILILEGGYNLtS 786  human
Q8IR37        769 kkgMGDLEYALAFQQLIMPIAYEFnPQLVLVSAGFDAAIGDPLGGcKVTAEGYGMLTHWLSALAsGRIIVCLEGGYNVnS 848  fruit fly
NP_001080486  711 ggkMGDVEYLMAFHRVVMPIAYEFnPQLVLISAGFDAARGDPLGGcQVSPEGYAHMTHLLMSLAgGRVILVLEGGYNLtS 790  African clawe...
AAI15263      518 ggkMGDPEYMAAFHHLVMPIAREFaPELVLVSAGFDAARGDPLGGfQVTPEGYAHLTHQLMSLAaGRVLIILEGGYNLtS 597  zebrafish
EEN43587      694 rggMGDPEYMAAFQQVVMPIAYEYsPELVIISAGFDAARGDPLGHcDVTPPGYAHMTHMLSSLAgGRVVLLLEGGYNLsS 773  Florida lancelet
EHJ64741      718 krgMGDAEYLSAMCSVVLPVAYEYgPQLVLVSAGFDAAVGDPLGGcKVTPECYGRMTHMLRGLAgGRVIVCLEGGYNVtS 797  monarch butte...
EDO33321      241 kshIGDADYIAAFQQILLPIAYEFdPDIVLVSAGFDSARGDPKGYcDITPEGYCHLTNMLMSLAgGKVVVILEGGYNItS 320  starlet sea a...
XP_002164574  252 ksgMNDADYILAFKHVLLPIAKEYnPELVLVSAGFDSGKGDPLGNcKVTPAGYAQMTKELMSLAdGKVVIVLEGGYNLkT 331  green hydra
XP_001942623  695 kngMGDAEYISVMQNIILPVAYEFcPELVLVSAGFDAAVGDPLGGcKVTPECYGHLTHFLSSLAnGKIILALEGGYNIdA 774  pea aphid
XP_003382755  264 larMGDAEYMSAFYQIIMPIAFEYqPELVIVSSGFDSGEGDPIGGyRVTPNGYAHMTHQLKSLAdGKIVVALEGGYNLtT 343  Amphimedon qu...
Feature 1                                                                  
Q9UBN7        787 ISESMAACTRSLLGDPPPlltlprppls--------galasitetiQVHRRYWRSLR 835  human
Q8IR37        849 ISYAMTMCTKTLLGDPVPtpqlgatalqkpptvafqscveslqqclQVQRNHWRSLE 905  fruit fly
NP_001080486  791 ISESMVMCTRSLLGDPPPvlsdlrppks--------salnsvckvrQAHRKYWRSLR 839  African clawed frog
AAI15263      598 ISESMSMCTSMLLGDSPPsldhltplkt--------satvsinnvlRAHAPFWSSLR 646  zebrafish
EEN43587      774 ISESMSECTKILLGDPCPpleysppcee---------avqsmlstlHVHQKYWRSLA 821  Florida lancelet
EHJ64741      798 ISYAMTMCTKALLGDPLQhqydpkqtvnp-------savesinnviRTHQKYWKSLK 847  monarch butterfly
EDO33321      321 VAESMCSCTSTLLGDPCPrldgpmvpcq--------svlksisnvvNVHKQFWKNLT 369  starlet sea anemone
XP_002164574  332 LASSMSSCLATLLGDPINvvinsnkssl--------sakqsvaktlFAIQKYWKSLN 380  green hydra
XP_001942623  775 VSYCMTMCTKALLGDPLPpldlefpick--------naqktikrvvNVQKNYWSCFK 823  pea aphid
XP_003382755  344 ISHSMSAVVQVLLGDTPRslescvpnds---------alasignaaKCLSKYWKSLR 391  Amphimedon queenslandica

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