Conserved Protein Domain Family
LOTUS_8_Limkain_b1
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cd09984: LOTUS_8_Limkain_b1 
The eighth LOTUS domain on Limkain b1(LKAP)
The eighth LOTUS domain on Limkain b1(LKAP): Limkain b1 is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. The protein contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
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Statistics
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PSSM-Id: 193598
Aligned: 4 rows
Threshold Bit Score: 159.305
Created: 8-Mar-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001119538 1475 LYVFAKNVRSLLHTYHYQQIFLHEFPNAYSKYVGEVLQPKQYGYSSLEEILGAIPQVVWIKGHGHKRIVVLKNDMK 1550 western clawed frog
Q9Y4F3       1486 LYLFAKNVRSLLHTYHYQQIFLHEFSMAYTKYVGETLQPKTYGHSSVEELLGAIPQVVWIKGHGHKRIVVLKNDMK 1561 human
XP_414895    1485 LYMFAKNVRSLLHTYHYQQIFLHEFLVAYSKYTGEVLQPKAYGCNNLEELLGAIPQVVWIKGHGHKRIVVLKNDMK 1560 chicken
AAI39490     1164 LYQFARRVRALLLTFHYSQLFLSEFSSAFSKHSGETLHTHNYGYNTLEELLAAIPQVVWIKGHGHKKIIVLKNDMR 1239 zebrafish
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