Conserved Protein Domain Family
LOTUS_7_Limkain_b1
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cd09983: LOTUS_7_Limkain_b1 
The seventh LOTUS domain on Limkain b1(LKAP)
The seventh LOTUS domain on Limkain b1(LKAP): Limkain b1 is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. The protein contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
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Statistics
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PSSM-Id: 193597
Aligned: 6 rows
Threshold Bit Score: 119.854
Created: 8-Mar-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8BJ34       1402 LRSLTAQLLVLLMSweg---dayLPVDELRRHYETTHSTPLNpceyGFMTLTELLKSLPYLVEVctn----dkAEEYVKL 1474 house mouse
NP_001119538 1400 LRSLTAQLLILLMSwde---sssLTVEQLCQVYQSVHGIPLNpceyGFVSLAELLKSLPYLVEVhtn----dlCEDSVQL 1472 western clawe...
Q9Y4F3       1411 LRSLTAQLLVLLMSweg---tthLSVEELKRHYESTHNTPLNpceyGFMTLTELLKSLPYLVEVftn----dkMEECVKL 1483 human
XP_414895    1410 LRTLTAQLLVLLMSwdg---asfLSVEQLKQHYETIHSTSLNpceyGFMTLTELLKSLPYLVEVftn----gaEEEYVRL 1482 chicken
AAI39490     1087 LRALTSQLLALMMSlpee--rsdVCVEELRCQYELSYGAPLNpceyGFISLAELLKSLPYLLQLsed---eggGNERVRL 1161 zebrafish
CAF95258      886 LRLLISQMLDLLMSqedgqvasgLRVDLLSERYLSVHGAPLNpceyGFLSLGELLKSLPYLVELyhkeddkggDEEWVRL 965  spotted green...
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