Conserved Protein Domain Family
LOTUS_6_Limkain_b1
?
cd09982: LOTUS_6_Limkain_b1 
The sixth LOTUS domain on Limkain b1(LKAP)
The sixth LOTUS domain on Limkain b1(LKAP): Limkain b1 is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. The protein contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
Links
?
Statistics
?
PSSM-Id: 193596
Aligned: 4 rows
Threshold Bit Score: 139.24
Created: 10-Mar-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q9Y4F3       1335 FKALAAQFVKLLRSqkdncLMMTDLLTEYAKTFGYTFRlqdyDVSSISALTqKLCHVVKVadieSGRQIQL 1405 human
NP_001119538 1324 IKALASQLVKLLRSqkdssINMPDLLTEYSKTFGYSLRlhdyDVSSVPALMqKLCHVVKImdtdLGKQIQL 1394 western clawed frog
XP_414895    1334 VKAVAAQFVKLLRSqkdncLMMSDLLSEYSKTFGYTLRlhdyDVSSVPALMqKLCHVVKVvdteSGKQIQL 1404 chicken
AAI39490     1011 VKALAAQLVKLLRAqrdsgLPVCRLLGEYSKTFGYCLRlqdyEASTLPALLhRLCHVVKVvdtpEGKEVQL 1081 zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap