Conserved Protein Domain Family
LOTUS_5_Limkain_b1
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cd09981: LOTUS_5_Limkain_b1 
The fifth LOTUS domain on Limkain b1(LKAP)
The fifth LOTUS domain on Limkain b1(LKAP): Limkain b1 is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. The protein contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
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Statistics
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PSSM-Id: 193595
Aligned: 8 rows
Threshold Bit Score: 131.778
Created: 10-Mar-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001119538 1248 TKQFSKEVVDLLRHQPhfrMPFNKFIPSYHHHFGRQCKltyYGFTKLLDLFEAIPDVLQVle--cgEEKILAL 1318 western clawed frog
Q9Y4F3       1259 TKQFSKDVVDLLRHQPhfrMPFNKFIPSYHHHFGRQCKlayYGFTKLLELFEAIPDTLQVle--cgEEKILTL 1329 human
XP_414895    1258 TKQFSKEVVDLLRHQPhfrMPFSKFIPSYHHHFGRQCKlayYGFTKLLELFEAIPEVLQVle--cgEEKILTL 1328 chicken
AAI39490      935 TRQFGREVVDLLRHQPhfrMAFSRFIPTYHHHFGRQCKlsyYGFSKLMELFEAIPDILQVle--cgEERLLVL 1005 zebrafish
CBY07753      915 TNKFGTEVAELLSECDkfsLPFTAFVPHYHHHFGRQCRlsnYGFTKLQDLFEAIPDIVTIde--ipNDKRLSL 985  Oikopleura dioica
XP_002129166  215 TNLFSRELVEILRLRHrcrMSFTEFVPAYHRQFGRQCKlsnYGFNKLLDLFESLPHVVQVve--daPEKYLQL 285  Ciona intestinalis
EFN83151     1076 TKLFAKEVVELLQHAPqcrMLFNKFVPSYHHHFGHQCRvsdYGFTKLIELFEAIPDVVKIeev-ngGERQISL 1147 Harpegnathos saltator
EFX71022      931 TKQFAVEVVELLKHAPqckLDFAKFIPAYHHHFGRQCRvsdYGCQKLVELFETIPETVQVfemdneIEKYVQL 1003 common water flea
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