Conserved Protein Domain Family
LOTUS_4_Limkain_b1
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cd09980: LOTUS_4_Limkain_b1 
The fourth LOTUS domain on Limkain b1(LKAP)
The fourth LOTUS domain on Limkain b1(LKAP): Limkain b1 is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. The protein contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
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Statistics
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PSSM-Id: 193594
Aligned: 10 rows
Threshold Bit Score: 124.779
Created: 10-Mar-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001074623 1174 VKRFTQDLLKLLKSQAskqVIVRDFSQAYHWCFSKDWDvteyGVCDLIDIISEIPDTTIClsq-qdDDMVICI 1245 house mouse
Q9Y4F3       1175 VKRFTQDLLKLLKSQAskqVIVREFSQAYHWCFSKDWDvteyGVCELIDIVSEIPDTTIClsq-qdNEMVICI 1246 human
NP_001119538 1164 VKRFTQDLLKLLKSQAskqVIVREFSQAYHWCFSRDWNvteyGVCDLVDIVSEIPDTTICvsq-qdGESVISI 1235 western clawed frog
XP_414895    1174 VKRFTQDLLKLLKSQAskqVIVKEFLQAYHWCFSKDWDvteyGVCELADIISEIPDTTIClsq-qdNEMVICI 1245 chicken
AAI39490      851 VKRFTQDLLKLLKMQAskqVSLQGFGSAYHWCFSRDWQvvdyGMCDLMDLLSEIPDSTISvcq-qdADVIISV 922  zebrafish
XP_001190301   18 VKRFGQDLLKVLKSQAskkVVINDFAPAFQRCLGRPWEtadyGICDIQDLLFDLPENWVTiew-dgDNTVISI 89   purple urchin
EFN83151      991 VRRFTSDLLRVLKSKAskqVALSEFPTVYSRVIAKPWDivdyGVCDIDDILGEVSENTVVvtsldsGDKMIAI 1063 Harpegnathos saltator
EFA08156      698 MRRFTSDLLRVLKVQPakqITVGDFPAAYERVMNRVFNpvdyGLCTFQDLLEEVPDNVVVith-ndDNLVISV 769  red flour beetle
XP_002427545 1024 IRRFTTDLLRILKNQTnrqIDLKDFGVQYEKIFGRTWDptyyGLCELEDLINCAPQSAIVmenkedGKILISI 1096 human body louse
XP_001943860 1032 VRRFTSDLLRVLKSVAskqVPIVDFGTLFEKTLGRVFDpvdyGLCSLDDLLSQVSENTVVigh-ldGQKSVAI 1103 pea aphid
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