Conserved Protein Domain Family
LOTUS_3_Limkain_b1
?
cd09979: LOTUS_3_Limkain_b1 
The third LOTUS domain on Limkain b1(LKAP)
The third LOTUS domain on Limkain b1(LKAP): Limkain b1 is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. The protein contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
Links
?
Statistics
?
PSSM-Id: 193593
Aligned: 8 rows
Threshold Bit Score: 142.61
Created: 8-Mar-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
NP_596912    1097 LIQFSREVIDLLKNQPSCILPISNFIPLYHHHFGKQCRVSDYGYSKLIELLEAVPHVLQILGMGSKRLLTLT 1168 Norway rat
Q9Y4F3       1099 LIQFSREVIDLLKSQPSCVIPISHFIPSYHHHFAKQCRVSDYGYSKLIELLEAVPHVLQILGMGSKRLLTLT 1170 human
NP_001119538 1088 LIQFSREVIDLLKNQPSCIMPVTKFIPTYHHHFAKQCRVSDYGYSKLLELLEAVPHVLQILGMGSKRLLTLT 1159 western clawed frog
XP_414895    1098 LIQFSREVIDLLKSQPSCIIPVSKFIPTYHHHFAKQCRVSDYGYSKLMELLEAVPHVLQILGMGSKRLLTLT 1169 chicken
AAI39490      775 LIQFSREMVDLMRSQPSCLMPVSRFIPAYHHHFAKQCRVSDYGYTKLLELLEAVPHVLQILGLGSKRLLTLT 846  zebrafish
EFN83151      915 LALFSRELVDLLKTAPHCQLPFNRFIPAYHHHFGRQCRVADYGFTKLIDLLEALTHTVQVMGEGNKRIVTLS 986  Harpegnathos saltator
XP_002427545  948 MSVFTRELLDLLKDTPKCLLPFSQFIPSYHRKYGRQCRVSDYGYTKLLDLLESMPHILQVIGNGTYKIVTLS 1019 human body louse
AAL89905      202 LFQISREVIELLKMSPKSTMKFNRFIPAYHNHFGKQCRVADYGYTKLIELFEALSNVVQIMGDGENRQITLS 273  fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap