Conserved Protein Domain Family
LOTUS_2_Limkain_b1
?
cd09978: LOTUS_2_Limkain_b1 
The second LOTUS domain on Limkain b1(LKAP)
The second LOTUS domain on Limkain b1(LKAP): Limkain b1 is a novel human autoantigen, localized to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures. The protein contains multiple copies of LOTUS domains and a conserved RNA recognition motif. The exact molecular function of LOTUS domain remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization
Links
?
Statistics
?
PSSM-Id: 193592
Aligned: 4 rows
Threshold Bit Score: 145.899
Created: 21-Mar-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q9Y4F3       1003 LKTFAPQVHSLLQThegtVPLLSFPDCYIAEFGDLEVvqe--nqGGVPLEHFItCVPGVNIAtaqnGIKVVKW 1073 human
NP_001119538  992 LKTFAPQVHSLLQThegtVPLLSFPDCYAAEFSALKEvqe--gqGGVPLEHLItCIPGVNIAfaqnGIKVVKW 1062 western clawed frog
AAI39490      677 LKVLAAHVHSLLQShegmLPLLSFPDCYAAEFSALSVaeegqleGSVPLEHLItCIPGVTIVtaqnGFKVIKW 749  zebrafish
XP_414895    1002 LKTFAPQVHSLLQThegtVPLLSFPDCYMSEFNDLEMvpe--gqGGVPLEHLItCVPGVNIAtaqnGIKVIKW 1072 chicken
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap