Conserved Protein Domain Family
LOTUS_2_TDRD5
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cd09975: LOTUS_2_TDRD5 
The second LOTUS domain on Tudor-containing protein 5 (TDRD5)
The second LOTUS domain on Tudor-containing protein 5 (TDRD5): TDRD5 contains three N-terminal LOTUS domains and a C-terminal Tudor domain. It belongs to the evolutionary conserved Tudor domain-containing protein (TDRD) family involved in germ cell development. In mice TDRD5 is a component of the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs), which are cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. The exact molecular function of LOTUS domain on TDRD5 remains to be discovered. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
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Statistics
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PSSM-Id: 193589
Aligned: 4 rows
Threshold Bit Score: 97.6403
Created: 11-Mar-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001038315  133 PAHLRSQLKQLLSHgpVRLSELESRYVAQFGKPLNvtqyGFFSISEMLsAAMDFIIMqqsrtgSQLLLRS 202  zebrafish
A0JM98        127 PATVKSDLRDLLSVspLLLSELEKAFSSRFGRSFQytryGFYSMLEVLrSITDIVEVkq--trAGSLLVL 194  western clawed frog
Q5VCS6        127 PAVVKSELKDLLALspVLLSDFEKAFARRFGRSFQymqyGFLSMFEVLnAASDVISVeqtragSLLTLKK 196  house mouse
XP_422264     129 PAAVKRELQDLLSSspLLLLDFNDAYYTRFKRTFQytqyGFSSLLEVFeSMSDTIMVketrggSLITLKK 198  chicken
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