1NZ8,1NPR,1M1G,1NPP


Conserved Protein Domain Family
NGN_Bact_1
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cd09891: NGN_Bact_1 
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Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1
The N-Utilization Substance G (NusG) protein is involved in transcription elongation and termination in bacteria. NusG is essential in Escherichia coli and associates with RNA polymerase elongation and Rho-termination. Homologs of the NusG gene exist in all bacteria. The NusG N-terminal domain (NGN) is similar in all NusG homologs, but its C-terminal domain and the linker that separates these two domains are different. The domain organization of NusG suggests that the common properties of NusG and its homologs are due to their similar NGN domains.
Links
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Statistics
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PSSM-Id: 193580
Aligned: 117 rows
Threshold Bit Score: 86.7612
Created: 10-Dec-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NPP_A; Aquifex aeolicus NusG forms a domain swapped dimer, contacts at 4 A
  • Comment:forms a ball and socket junction
  • Comment:one group says that this exists as a monomer, another group contends that they form domain swapped dimers as shown
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #                                 #                                          
1NZ8_A         3 EWYAVHTlVGQEEKAKANLEKRIKafglqDKIFQVLIPteevvelreg-------------------------------- 50  Thermus thermop...
1NPP_A        12 KWYALQVePGKENEAKENLLKVLEleglkDLVDEVIVPaeekvviraqgkekyrlslkgnardisvlgkkgvttfrieng 91  Aquifex aeolicus
YP_001956174   4 QWYVVHVySGHEYKVKKGLEMTVAnlnmqDTISQILVPteevievkq--------------------------------- 50  uncultured Term...
Q9Z9A5         3 KWYVVQVfTAQEKKVKKALEDFKEssgmtDFIQEIILPienvmevkk--------------------------------- 49  Chlamydophila p...
ADI37955       3 NWFVVHVlSAQEKKVKKAIEEQRDlkgmtDLIDIVLLPvenisevkk--------------------------------- 49  Waddlia chondro...
YP_002249161   4 QWYVVHTmSGFEEKVKASIEERVKtkgleDKISRILIPtekiievkg--------------------------------- 50  Thermodesulfovi...
YP_389480     12 RWYIVHTySGFEQRVEQTIRQMIRtgeaqDLIEEVVVPtekvielvk--------------------------------- 58  Desulfovibrio d...
YP_914550      4 RWYSVSVlSNFEKKVAEAIRQAVVekgieDQIDEVLVPteevieirr--------------------------------- 50  Paracoccus deni...
YP_004051604   5 QWYVVHTySGFEKRVKKLLEEKIKnenlyDSFGEILIPtenvvelvk--------------------------------- 51  Calditerrivibri...
NP_969768      4 KWYIVNVqTSCENTAKKAIEEKIKsskmeEFFGEILIPaesvvelvk--------------------------------- 50  Bdellovibrio ba...

Feature 1                                                   #  # #                               
1NZ8_A        51 ---------------------------------gkkevvrkkLFPGYLFIQMDLgdeeePNEAWEVVRGTPGITGFVGa- 96  Thermus thermop...
1NPP_A        92 evkvvesvegdtcvnappiskpgqkitckenkteakivldnkIFPGYILIKAHM-----NDKLLMAIEKTPHVFRPVMv- 165 Aquifex aeolicus
YP_001956174  51 ---------------------------------nkkkikkrkFYPGYIFVEMTI-----NNSTYWLIRNTAGVTGFLGg- 91  uncultured Term...
Q9Z9A5        50 ---------------------------------gehkvvekyIWPGYLLVKMHL-----TDESWLYVKSTAGIVEFLGg- 90  Chlamydophila p...
ADI37955      50 ---------------------------------gqqkvvekrMWPGYLLVKMTL-----TDESWGYICDVPGVIGFLGg- 90  Waddlia chondro...
YP_002249161  51 ---------------------------------kkkkeqekkFYPGYILVEMEL-----NDDTWHLISTTQRVTGFVGg- 91  Thermodesulfovi...
YP_389480     59 ---------------------------------gekrtstrkFYPGYIMVKMIM-----TDFSWHLVQNINRVTGFVGg- 99  Desulfovibrio d...
YP_914550     51 ---------------------------------gkkvtserrFMPGYVLVRMEL-----SDKTYHLVNSINRVTGFLGa- 91  Paracoccus deni...
YP_004051604  52 ---------------------------------gtkkiskksTFPGYILVNMVM-----NTENWHKVKSIPKVTGFVGg- 92  Calditerrivibri...
NP_969768     51 ---------------------------------gqkqtksrkFFPGYIFVQMFL-----NDETWHLVRNSSKVTGFVGgt 92  Bdellovibrio ba...

Feature 1              #       #    
1NZ8_A        97 gMRPVPLSPDEVRHILEVS 115 Thermus thermophilus
1NPP_A       166 gGKPVPLKEEEVQNILNQI 184 Aquifex aeolicus
YP_001956174  92 -VKPIPISQFEVENILNTV 109 uncultured Termite group 1 bacterium phylotype Rs-D17
Q9Z9A5        91 -GVPVALSEDEVRSILTDI 108 Chlamydophila pneumoniae AR39
ADI37955      91 -DQPTPLTPQEVDEILQDI 108 Waddlia chondrophila WSU 86-1044
YP_002249161  92 -KKPAPIPQEEVEMILQQL 109 Thermodesulfovibrio yellowstonii DSM 11347
YP_389480    100 kNRPTPMRDSEAERILAMM 118 Desulfovibrio desulfuricans subsp. desulfuricans str. G20
YP_914550     92 qGKPMPMRDDEVNAILHRT 110 Paracoccus denitrificans PD1222
YP_004051604  93 -VNPVPIPEQDVKAMIDLA 110 Calditerrivibrio nitroreducens DSM 19672
NP_969768     93 kTRPPEVPEAEVLRVTQQM 111 Bdellovibrio bacteriovorus HD100

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