Conserved Protein Domain Family
thyroid_peroxidase

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cd09825: thyroid_peroxidase 
Thyroid peroxidase (TPO)
TPO is a member of the animal heme peroxidase family, which is expressed in the thyroid and involved in the processing of iodine and iodine compounds. Specifically, TPO oxidizes iodide via hydrogen peroxide to form active iodine, which is then, for example, incorporated into the tyrosine residues of thyroglobulin to yield mono- and di-iodotyrosines.
Statistics
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PSSM-Id: 188657
Aligned: 9 rows
Threshold Bit Score: 877.92
Created: 15-Dec-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Comment:by similarity to other members of this family
  • Citation:PMID 1320128

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
P07202        167 GASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDd----------rYSDLLMAWGQY 236  human
XP_001235673  113 GASNTALARWLPPAYEDGLSQPRGWDPSVRYDGVLLPLVREVTRKIINASNEAVTEDn----------lYSDIIMVWGQY 182  chicken
NP_001027595  166 GASNNPFVRWRPAQYENEFSTPIGWDSQRSYNGYQLPVVRKVSNDIMRTSNTRVTGDp----------lYSHMLVVWGQY 235  Ciona intesti...
CAF94278      100 GAANIPLVSWLPAEYEDGEREPKGWNRGRLYKGVPLPSVTQVSREILRSSSAPKPDV------------YSQMLAEWGQF 167  Tetraodon nig...
AAL74416        1 MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATmqrn-----lkkRGILSPAQLLS 75   human
XP_002936348  106 GAANTLLARWLPAQYEDGIGEPKGWREEFLYNGFRLPQVREVTNKIIHASSKAFREDd----------lYSHIIIEWGQY 175  western clawe...
EEN62286       82 GSSMTPFKRFLPPIYENQWNEPVGWNKTREYNGFTLPSVRHVSNQLMTTPTNVADPD------------YTHMLTQFGQF 149  Florida lancelet
EEN62288      238 GSSLTPFKRFLPPIYENQWNEPVGWNKSREYNGFTLPSVRHVSNKLMTTAQNVDDPD------------FTHMLTQWGQF 305  Florida lancelet
CBY06733      142 GASNMPQRRVLPSIYEDNISLPVGIDPTIRYSAGSRSVDQTQGQPLPLVRSVSNSLArvadadvisdiqYTHLLTVWGQY 221  Oikopleura di...
Feature 1                                                                                         
P07202        237 IDHDIAFTPQSTSKAa-----FGGGADCQMTCENQNPCFPIQLPEEarpa---agtACLPFYRSSAACGTgdqgALFGNL 308  human
XP_001235673  183 IDHDISFTPQSISRTs-----FLTGKECQMTCERQNPCFPIKLKEEanps---sgmDCLPFYRSSPACGTgdhsILFGNL 254  chicken
NP_001027595  236 IDHDLDFTPQSLSTSt-----FQGLTDCKKTCKNESPCYPMQVPSDdpri---ttaSCLPFFRSAAVCGTgdtsSLFHSI 307  Ciona intesti...
CAF94278      168 VDHDIGFTPQSSSAA------FPASVDCLATCENTHPCFPIETDSVh---------GCKPFFRSTAACFD----TVWPDV 228  Tetraodon nig...
AAL74416       76 FSKLPEPTSGVIARAaeimetSIQAMKRKVNLKTQQSQHPTDALSE----------DLLSIIANMSGCLPymlpPKCPNT 145  human
XP_002936348  176 IDHDIAFTPQSVSKTp-----AIGSVDCKSTCENLYPCYPIKLSEEdpl----sqgGCIPFYRSSSACGTgrggLKFGNP 246  western clawe...
EEN62286      150 LDHDTDLTATAVGRTmf---tPMGTVTCGMTCDNIMPCFPIPIPDDdpridnerdrACMPFTRSSAVCGTgetsTLFNTV 226  Florida lancelet
EEN62288      306 LDHDTDLTATAVGRTmf--tpGMNSTSCEETCDNIMPCFPIPIPDDdpridnvlekACMPFTRSSAVCGTgetsTLFNTA 383  Florida lancelet
CBY06733      222 IDHDLGITPQSKSISs-----FQGNTRCESTCENLNPCFPIQLPAGdpkl--llgrQCLPFFRSASVCGTg--aIVPGGL 292  Oikopleura di...
Feature 1                                                                                         
P07202        309 stanPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSaEGLLRVHARLR-DSGRAYLPFVPPrapaacapepgipgETRG 387  human
XP_001235673  255 salnPRQQINGLTSFIDASTVYGSTSTVENKLRNLTSeEGLLRVNSKHN-DNGQEYLPFTDRvpspcaq-dsnaseDERI 332  chicken
NP_001027595  308 r---PREQINAVTSFVDASTVYGSTDSLNRILRNLTNdDGLMKVNTMFK-DGNWDYLPFDPNnpcvqd---pfdasGVNI 380  Ciona intesti...
CAF94278      229 eralQRQQMNAITSFMDASVVYGHTPGLESSLRDLAGlNGKLVVNSKFKdPKGRPYLPSVAKesscl-----qspeGERV 303  Tetraodon nig...
AAL74416      146 clanKYRPITGACNNRDHPRWGASNTALARWLPPVYE-DGFSQPRGWNP-GFLYNGFPLPPVrevt-------rhvIQVS 216  human
XP_002936348  247 sllnPREQINGLTSFIDASTVYGSSESLQHKLKNLSSeEGLLRVNVKYS-DSSREYLPFETPsacmqd---ptadnAERI 322  western clawe...
EEN62286      227 i---AREQINQITSFIDASNVYGSKFAFAQSLRDFSTdDGLLRVQEGED-ISSGMASPFQNEavtscn---qdpngGDIV 299  Florida lancelet
EEN62288      384 i---AREQINQVTSFIDASNVYGSTLDVAQSLRDFSTdDGLLRVQEGADiSSGMDLLPFQDEevsscn---qdpngGDIV 457  Florida lancelet
CBY06733      293 swqqSREQVNGNTAFLDASTVYGSNLKTKELVRDQEK-PAFLKVNSKFN-DNGRAYLPFTADkcvqe-----instQPDV 365  Oikopleura di...
Feature 1                 #  #                                                                    
P07202        388 PCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSa---------------------------------dAVY 434  human
XP_001235673  333 ECFMAGDSRSSEVTSLTAMHTLWLREHNRLARALKAINSHWSa---------------------------------eTVY 379  chicken
NP_001027595  381 PCFHAGDGRVSEHLTLSAIHTVWVREHNRIARMLKSMNPHWSg---------------------------------eIIY 427  Ciona intesti...
CAF94278      304 ECFLAGDGRVSEGLPLTSLHTLFLREHNRIAEALKCINDHWNpetiyqetrkiigaliqnersllnchgavsspnsiTTD 383  Tetraodon nig...
AAL74416      217 NEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGSD-----------------------------------CQM 261  human
XP_002936348  323 DCFFAGEGRANEVITLAAVHTLWLREHNRIAKALKKLNPHWNs---------------------------------eTTY 369  western clawe...
EEN62286      300 PCFLAGDGRVNEVNTLIASHTIWVREHNRLARELKRINPHWDg---------------------------------eQIY 346  Florida lancelet
EEN62288      458 PCFLAGDTRNNEVNTLIASHTTWVREHNRLARELKSINPHWDg---------------------------------eQIY 504  Florida lancelet
CBY06733      366 PCWLAGDGRAAEVVPLASIHTIWIRWHNFLAEKLSSLNGHWSn---------------------------------eQVY 412  Oikopleura di...
Feature 1                                                             #  ##  #  #                 
P07202        435 QEARKVVGALHQIITLRDYIPRILGPEAFqqyvgpyegydstaNPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPd- 513  human
XP_001235673  380 QEARKIVGALHQIITLRDYIPKIIGPDAFnqyiglykgydptvNPTVSNVFATAAFRFGHATIQPIVRRLNAQYLDDPe- 458  chicken
NP_001027595  428 QEARKIVGAYHQIVHWKEYVPKIIGPAGLrmmgnyt-gyreneNPTVSNVFATAAFRFGHATISPQFRRLDENFNNHPq- 505  Ciona intesti...
CAF94278      384 ELHISEEIRDFQVITMRDYIPKIIGTESFqdhigpycgynpsvNPSTANVFSTAAFRFGHATIPTVIRRLDKNFEEHEl- 462  Tetraodon nig...
AAL74416      262 TCENQNPCFPIQIITLRDYIPRILGPEAFqqyvgpyegydstaNPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPd- 340  human
XP_002936348  370 QEARKIVGALHQIITFRDYMPKILGKAAYdqyig----lykgyNQKTNPSISNIFTTAAFRFGHATIPPMVHRLNSQYvd 445  western clawe...
EEN62286      347 QEARKIVGSEMQHITFTEYLPKILGQRGMdqmgeya-gynpnvNPSTRNEFATAAFRFGHAAIGAFVRRFDENYQEAAi- 424  Florida lancelet
EEN62288      505 QEARKIVGSEMQHITYTEYLHKILGPTGMdqigeys-gydpnvNPATRNEFATAAFRFGHAAISPTVRRFDENYEEDPv- 582  Florida lancelet
CBY06733      413 QETRKIVSAVHQKVTFYDYLPKIIGQTAFdtlgvnypgydetiDATVSNVFTTAAFRFGHAAIRSTVFRLNEFFQEHEq- 491  Oikopleura di...
Feature 1                  #                                                                      
P07202        514 lPGLWLHQAFFSPWTLLRG-----------------------GGLDPLIRGLLARPAKLQVQDQL-------MNEELTER 563  human
XP_001235673  459 lPNLHLHEVFFSPWRLIKE-----------------------GGLDPLIRGLLAHPAKLQVQGQL-------MNEELTDK 508  chicken
NP_001027595  506 fPTILLHEAFFSPWRMIRE-----------------------GGMDPILRGLIGRPAKLIKADEM-------MHEELRDK 555  Ciona intesti...
CAF94278      463 yPSLELHNTFFTPWRVVKEdaninsdttavnqavksssfvstGGIDPIIRGVIGSPAPMPSADKV-------MSKELTDR 535  Tetraodon nig...
AAL74416      341 lPGLWLHQAFFSPWTLLRG-----------------------GGLDPLIRGLLARPAKLQVQDQL-------MNEELTER 390  human
XP_002936348  446 dPKYPSLPLNEVFFRPWRI-----------------------VKEGYNDWREFCGLSRLATPADL-------INAELTEK 495  western clawe...
EEN62286      425 -GNVALSDAFFSPWRVFRE-----------------------SGIDPVVRGLIGGFAKLVTPTDV-------LHEELSQN 473  Florida lancelet
EEN62288      583 iGNVALHDAFFSPWRIMRE-----------------------SGIDPVVRGLIGGSAKLVTPTDSdgvftpaQRAEISRV 639  Florida lancelet
CBY06733      492 fKNLPLHRTFFSPWRIVRE-----------------------GGLDPVLRGLVFGQAKLVAPRSV-------MNDELREK 541  Oikopleura di...
Feature 1                    #      #                                                             
P07202        564 LFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLst------aIASRSVADKILDLY----KHPDNID 633  human
XP_001235673  509 LFVLSNNGSLDLASLNLQRGRDHGLPGYNDWREFCDLPRLETQTDLnt------iITNQKVTEKIMELY----HIPSNID 578  chicken
NP_001027595  556 LFALQNQVALDLASLNLQRGRDHALPLYNDWREECGLARANNFSDLag------eIKDKAIRDKLEALY----GHPGNID 625  Ciona intesti...
CAF94278      536 LMVLNVPQHMDLAALNLQRGRDHALPGYNAWREFCGLKRIQTLSDLie------vVGNCAVAEKIFNIY----KHPDNID 605  Tetraodon nig...
AAL74416      391 LFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLst------aIASRSVADKILDLY----KHPDNID 460  human
XP_002936348  496 LLVMTNNGSMDLASLNLQRGRDHGLPGYNDWREFCGLSRLATPADLin------aVSDQKLVAKMIALY----SHPDNID 565  western clawe...
EEN62286      474 LFKLRNQIALDLASLNTQRGRDHGIPFYNDWRVFCNLTRAASFDDLsg------eISNQDVRDTLADVY----GDVNNID 543  Florida lancelet
EEN62288      640 TLARVICDNTGITRLPPDVFRLTDVADMVACEDIPGINLQVWEEIPadepcgepaEVENAHVQKCGSNSpethIYTCDPG 719  Florida lancelet
CBY06733      542 LFQLENKSGFDLASLNLQRGRDHGLPLYGAWKTFCEGFMPASLGYSa--------STDYITDPEVVNRLn---QDIANTD 610  Oikopleura di...
Feature 1                                                                                         
P07202        634 VWLGGLAENFLP---RARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKH-SLSRVICDNTGLTRVPMDAF 709  human
XP_001235673  579 VWLGGLVEDFLP---GARTGPLFACLIGKQMKALRDGDRFWWENDNVFTDAQKHELKKH-SLSRVICDNTGISDVPIDAF 654  chicken
NP_001027595  626 LWLAGLSEDLMD---GSRGGPVFTCLLARQFKFLRNGDRFYYENPNVFTPNQVTALNRL-SFARVLCDNSGLTRVQPDLF 701  Ciona intesti...
CAF94278      606 VWLGGLVEKFLP---GARTGPLFACLIGRQMKALRDGDRFWWEAEGVFSEHQRAALLNT-SLSRIICDNTDIKELLPDAF 681  Tetraodon nig...
AAL74416      461 VWLGGLAENFLP---RARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKH-SLSRVICDNTGLTRVPMDAF 536  human
XP_002936348  566 VWLGGLAEDFLP---GARTGPLFACLIGKQMQALREGDRFWYENNNIFTKIQRSELEKH-SLSRVICDNTGLSHVPLDAF 641  western clawe...
EEN62286      544 LWPAAQLEDHED---GARVGPTFRCMLAEQFKALRDGDRFWFESDGVLTASQRTEIRQV-TYARVICDTTGITRLPPDVF 619  Florida lancelet
EEN62288      720 YEMSGAAEIRCLggvPDNPPPTCSACPQRYPELHPSGSFGIYQNQCFWYSPRKHKRRLTyEKAKLKCESNGGTLAMIKDD 799  Florida lancelet
CBY06733      611 IWIAGLLEDIPI---GSRVGPTFQCLLLEQFSRYRTGDRFWFENPSILSAAQTQAIRAV-DMGLVLCETSDIGRVPPDAF 686  Oikopleura di...
Feature 1                                            
P07202        710 QVGKFp----------EDFESCDSITGMNLEAWRE 734  human
XP_001235673  655 QLGKFp----------QDFKHCSNIDGMNLEAWQE 679  chicken
NP_001027595  702 MLRDT-----------SQFVDCANIPNLDLSQWRE 725  Ciona intestinalis
CAF94278      682 VFREYp----------CGYTSCDHLPSVDLEAWKE 706  Tetraodon nigroviridis
AAL74416      537 QVGKFp----------EDFESCDSIPGMNLEAWRE 561  human
XP_002936348  642 LLGNYp----------DNFVSCDSIPGINLEAWKE 666  western clawed frog
EEN62286      620 RLTDV-----------ADMVACEDIPGINLQFWEE 643  Florida lancelet
EEN62288      800 DMQTFmlsllkkkrqkKYWIGLDDIYEEEKFMWND 834  Florida lancelet
CBY06733      687 VQEPTi----------ATMIPCSSKTVINLDFWRE 711  Oikopleura dioica

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