Conserved Protein Domain Family
linoleate_diol_synthase_like

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cd09817: linoleate_diol_synthase_like 
Linoleate (8R)-dioxygenase and related enzymes
These fungal enzymes, related to animal heme peroxidases, catalyze the oxygenation of linoleate and similar targets. Linoleate (8R)-dioxygenase, also called linoleate:oxygen 7S,8S-oxidoreductase, generates (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate as a product. Other members are 5,8-linoleate dioxygenase (LDS, ppoA) and linoleate 10R-dioxygenase (ppoC), involved in the biosynthesis of oxylipins.
Statistics
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PSSM-Id: 188649
Aligned: 20 rows
Threshold Bit Score: 637.843
Created: 4-Sep-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative hemeputative
Feature 1:putative heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
Q9UUS2      97 SREGKKLTDG--------------------LINDLWDSLDHPPVAs---------------LGKGFSFREp------DGS 135  Gaeumannomyces g...
BAE66487    77 SKLRDGITAE--------------------FVKTLWNSLDHPPVAr---------------LGDEYKYRAa------DGS 115  Aspergillus oryzae
BAE60972   228 SKAREKLTGV--------------------LIDTLWQSLPHPPMTy---------------LGNKYQYRTp------DGS 266  Aspergillus oryzae
EFI91160    91 KLLPAQLEHLltlmarlgsgndfssrvqeaVIDLLYKDLPHPPACylsvlhqaglnlnvplANVNYAYRTa------DGS 164  Schizophyllum co...
EER41266    76 KFVKDTIKGK--------------------PMNDRLLAMENIIAMvg-------------aLPPNNKHRIkltniliTKL 122  Ajellomyces caps...
EEA28809    84 SAVGSTLEHG--------------------VVQSLWDTLPNPCPGw--------------tQHSGPQYRRa------DGS 123  Penicillium marn...
EAA31524   100 SVARADIIEK--------------------QVKIKYDRMLHPPLSy---------------LGDAFKYRTa------DGK 138  Neurospora crass...
EAA58704    22 STLTSLLSSV--------------------HADLLSQAHRIPADIrtl-----------reLSQAGLQGGli----dDKK 66   Aspergillus nidu...
EDU45470    89 SGLGAKVADG--------------------FIAMLWNDLPHPTPTh---------------AGPSARYRKh------DGS 127  Pyrenophora trit...
EAT89123     3 SQLRSLLGTIr------------------rKPTQASDGRTSEASSg---------------LKNNEKTTIg-----hDLK 44   Phaeosphaeria no...
Feature 1                                                                                      
Q9UUS2     136 NNNIHLPSLGAANTPYARSTKplvf---qnpnPPDPATIFDTLMVrdpakfr---phpnkisSMLFYLATIITHDIFQts 209  Gaeumannomyces g...
BAE66487   116 NNNPLYPQLGAAGSHYVRSVTaqhp---rpyvLPDPSLIFDTILArkgpake----hpseisSTLFHFATIIIHDLFRtd 188  Aspergillus oryzae
BAE60972   267 YNNPLQPDLGKAGSPYARNVPklkh---mhgvPPDPGLLFDLLMArsdetfk---enpaglsSVLFYHATIIIHDIFRsn 340  Aspergillus oryzae
EFI91160   165 YYNPLFPTLGMAGTPYARSVPsanct--plnnLPDAGLVFDTLLRrkegtfk---eheggmsSLFFAMADLIIHCIFDtd 239  Schizophyllum co...
EER41266   123 WDSLEHPPINFQGPQFYYRTPdgsynnvhfpnLGKAGMPYARSIRsdt------------rlPGVRPDPGLLFDHIFRtd 190  Ajellomyces caps...
EEA28809   124 FNNLYEPRVGRAGEAYIRNVVslrd---qskdLPSPEDVFEKLFRrrtpadggfrkhpcgisANMFYMATLITHDLFNtd 200  Penicillium marn...
EAA31524   139 FNSAINPHLGQAGAPYAKTVPakth---plgaLPDPGDLFDQLMAreengrp----sqsglsSMLIYHATIIIHDLFRtn 211  Neurospora crass...
EAA58704    67 YLNIMYPHLGASGSHYARTVTpkhp---rpavLPDPGLIFDSLLAr---------------eGPAKEHPAEISSNLFYfa 128  Aspergillus nidu...
EDU45470   128 GNNPHNPEMGKAGSPYARNVPp---------mKPKGPNLPDVEDVy---------------eALLKRSGPFRPHPSGL-- 181  Pyrenophora trit...
EAT89123    45 NLGIKNARFAVEAITTLASGEpldd----kdnLLENGVQMLQGLPtnsgls------akvsdGFIAMLWNDLPHPSPT-- 112  Phaeosphaeria no...
Feature 1                                                                                      
Q9UUS2     210 prdfNINLTSs--yLDLSPLYGRNHDEQMAVRTg---------kDGLLKPDtfsskrVIGFPPGvgafliMFNRFHNYVV 278  Gaeumannomyces g...
BAE66487   189 dadiTKLKNSs--yLDLGPLYGHNEDQQNQVRSf---------qDGLLKPDtfaeqrLLGQPPGvcaliiAFNRFHNYIV 257  Aspergillus oryzae
BAE60972   341 rfdpNISDTSs--yLDLAPLYGSSLEDQMKVRTk---------vRGLLKPDtfsekrLIGMPPGvnailvMYNRFHNYVA 409  Aspergillus oryzae
EFI91160   240 hkdiTKNNTSs--yLDLSILYGNSEEQLNGVRRhd--------gTGRLWDDvfadrrLLLMPPStcallvLFCRNHNHIA 309  Schizophyllum co...
EER41266   191 rrdmNINNNSs--yLDLSPLYGSSLEDQLKIRTm---------kNGFLKPDtfhderLIGQAPGanvllvLYSRFHNYVA 259  Ajellomyces caps...
EEA28809   201 itnrFRNKTTs--yVDMAWLYGKFHDCIGWNQEmqdsvrdkaghCGKLHADvfadprLDLQPPGviamalLWCRNHNWIA 278  Penicillium marn...
EAA31524   212 dndkNISDTSs--yLDLSPLYGFTEEMQRKVRDet-------ygLGLLKPDtfaedrLLRQPPGvcimlvMYNRYHNYAA 282  Neurospora crass...
EAA58704   129 i-iiIHGDFQf---RSYTEQTQVRTFTDGLLKP-----------DTFAEKR------LLSQPPGvcallvAFNRFHNYVV 187  Aspergillus nidu...
EDU45470   182 ----NRLFFSfatiVIHECFQTSRTDPWINETS-----------NSIASER------IMMMPPGvvavllMFSRNHNHVA 240  Pyrenophora trit...
EAT89123   113 ----TAGPTTryrrHDGGGNNPHNPEMGKAGPNlpdv---edvyEALLKRKg-----PFRSPFTqelntpWFFSFANHRH 180  Phaeosphaeria no...
Feature 1      ##                                                                              
Q9UUS2     279 TQLAKINEGGRFKRPTTPDDTAGwe------------------------------------------------------- 303  Gaeumannomyces g...
BAE66487   258 KELALINEGGRFSLPAGVTPDSPkygq----------------------------------------------------- 284  Aspergillus oryzae
BAE60972   410 DNLLKINEGGRFSLPATKSEEDKkaa------------------------------------------------------ 435  Aspergillus oryzae
EFI91160   310 QRILDINEKGKYRSVDSFSDDARk-------------------------------------------------------- 333  Schizophyllum co...
EER41266   260 QTLLQINEGGRFTPKGDDEASLAk-------------------------------------------------------- 283  Ajellomyces caps...
EEA28809   279 EQLLIESKDDPRFSAVPKNDDQQgl------------------------------------------------------- 303  Penicillium marn...
EAA31524   283 TQLRRINENGRFSVPREYREAKFiaaakyfdkdrllenidnqeilkrfidankvfesngrirtkeyqdaenaldvfinkv 362  Neurospora crass...
EAA58704   188 TELARINEAGRFDLPTGGQEKSPdyvw----------------------------------------------------- 214  Aspergillus nidu...
EDU45470   241 ESLFSVNEDGKYKPWDTLDDEGKk-------------------------------------------------------- 264  Pyrenophora trit...
EAT89123   181 SRSGFPNLEGPDPWINETLKLRGse------------------------------------------------------- 205  Phaeosphaeria no...
Feature 1                                                                                      
Q9UUS2     304 -------------------tYDNSLFQTGRLITCGLYINIVLGDYVRTILN--LNRANTTWNLDPRTKEGKSllskptPE 362  Gaeumannomyces g...
BAE66487   285 ----------------aqakRDNDLFQTGRLVTCGLYVNIILGDYLRTILNlnTNPVDSDWKLDPRTEISALnsp-tvPR 347  Aspergillus oryzae
BAE60972   436 -----------------lakQDEDLFQTARLVTNGLYVNISLHDYIRGLAN--VHHSSSDWTLDPRVKINKIfdsegvPR 496  Aspergillus oryzae
EFI91160   334 -------------------aQDDEIFHRARLVNCGFFMQVILADYVGAILG--LVRDGLPWRLDPLMTMRREshe-fsPQ 391  Schizophyllum co...
EER41266   284 --------------------LDEDLFQTARLIVGGLYINISLHDYLRAITN--THHSASSWTLDPRVDIPDSlvksgpER 341  Ajellomyces caps...
EEA28809   304 ------------------elLDEHLFQTARNINVGTFATVVLKDYVRMLLG--INRENTTWTLPINQEFSPStkn-diPK 362  Penicillium marn...
EAA31524   363 qpdekqvqafkdsydaawkkLDDDLFHTARLITCGLYIQVSVHDYLRALMG--FHQYDTNFTLDPRVNQSEAke---vSR 437  Neurospora crass...
EAA58704   215 ----------------alqkRDEDLFQTGRLYIIPSSSNTTTDIDKANACMg-NRVTCGLYVSIILNDYLRTi-----LN 272  Aspergillus nidu...
EDU45470   265 -------------------wQDEDIFQITRNINVGFFASVVLRDYVAAILN--TPRANSEWSLDLGKEIKQGgt--rvER 321  Pyrenophora trit...
EAT89123   206 -------------------hADNDIFQLTRNINVGFFAAVVLHDYVAAILN--TPRANSEWSLDLGKEIKQGgt--rvER 262  Phaeosphaeria no...
Feature 1                #  ####  #                                                            
Q9UUS2     363 AVGNQVSVEFNLIYRWHCTISERDDKWTTnamrealgg----------qdpatakmEDVMRALGMFEKn----------- 421  Gaeumannomyces g...
BAE66487   348 GTGNQVSAEFNMIYRWHAAISNQDEAWAHefmksvfga---------evnpgtlsvDEFVGGLRRWFEg----------- 407  Aspergillus oryzae
BAE60972   497 GIGNQVSVEFNLLYRFHSIISRRDEKWMNeffadifgq---------dkkvdqltpQEFIQGLYRFEQs----------- 556  Aspergillus oryzae
EFI91160   392 GEGNVVSIEFNLLYRWHAALSAQDTKWTEglfksvfgq---------dvdfdkvtpTDFKRVVGRMFGq----------- 451  Schizophyllum co...
EER41266   342 GIGNQVTSEFNLLYRFHSCTSLGDEKWLNdyfagifkst--------gksleeltlKDGMQAIARFETl----------- 402  Ajellomyces caps...
EEA28809   363 ATGNQCSIEFNFIYRWHSAISVEDEQWIEglfedlekrlgpnwmnnrlgsilpariPAFVQERHDERA------------ 430  Penicillium marn...
EAA31524   438 GLGNQVTVEFNLLYRFHCAISRGDEEYLEnyleeyfekhs-----rsdwnpkemglQEFLMEMGQARErrkndppvkpcd 512  Neurospora crass...
EAA58704   273 LNDNPTNSDWKLDPRKNLSVFDSEGLPRGvgn----------------------qvSAEFNMIYRWHAt----------- 319  Aspergillus nidu...
EDU45470   322 GTGSHVSVEFAVLYHWHAALSAADDQWMEdiirsvypd----------lehiddvtIEMFHQVMKVYGhd---------- 381  Pyrenophora trit...
EAT89123   263 GTGSHVSVEFAVLYHWHAALSAADDKWMEdil---------------------rsvHPNMRSVDDITVem---------- 311  Phaeosphaeria no...
Feature 1                     #                                                        #  #   #
Q9UUS2     422 ------iPDEPEKRTLAGLTRQSDGAFDDTe--------------lVKILQESIEDVAGAFGPNHVPAcMRAIEILGIKQ 481  Gaeumannomyces g...
BAE66487   408 ------iDTDPARWTFNGLQRQQDGSFRDAd--------------lVNILQTGTECVAGAFGANNIPEaMKAIEMLGIQQ 467  Aspergillus oryzae
BAE60972   557 ------iPEDPSEREFGGLKRGENGKFSDAd--------------lVQLMKDSMEDPAGCFGARMVPKaLRVIEILGIIQ 616  Aspergillus oryzae
EFI91160   452 -------PQDPRTATFTDYAGQRLERHPEEgaatpdgagrfadadlARVLQDATSWRAGSYGARAIPAaLRVIEVMGIEQ 524  Schizophyllum co...
EER41266   403 ------iPKDPSQRNFGGIKRGEDGRFRDEd--------------lVRILKASIEDPAGAFGPKNTPKaLRVVEILGIQQ 462  Ajellomyces caps...
EEA28809   431 -------STDPRCRTYFALNPEVKRDPKTHkypd---------aalADFIKRATESSAGAFGGRQVPNvFKDIEIMSIRH 494  Penicillium marn...
EAA31524   513 iefglknKDEDEARKKMAFKRDPITKLFNDeq-------------mVEHLTKVMDEPISNFGPRNVPRsLKAVEVMGILQ 579  Neurospora crass...
EAA58704   320 -------TSNEDEKWLNELSIRVFGSKVDP----------------STLSVQRYLNGLHEYLGKTAPGePNTWTFGDLNR 376  Aspergillus nidu...
EDU45470   382 -----lmKKEPCQWTFGGLERGPDGKFDDEq--------------lAELIKDCIEEPAHAFGARGTPAsLKVVDIMGQLQ 442  Pyrenophora trit...
EAT89123   312 ------fHEVMKEWTFGGLQRGPDGRFKDAe--------------lAELIKTCTEEPAHAFGAHGTPAsLKVVDLMGQLQ 371  Phaeosphaeria no...
Feature 1                                                                                      
Q9UUS2     482 SRTWN------VATLNEFRQFIGLTPHdsfy-hmnpDPKICKILAQMYD-SPDAVELYPGIMAEAAKppfspgsglcPPY 553  Gaeumannomyces g...
BAE66487   468 GREWG------LATLNEFRHFFKLKTYstfe-evnpDPAVWEALEALYG-HPDDIELYVGIQAEEAKkpcfpgsglcPNF 539  Aspergillus oryzae
BAE60972   617 ARKWQ------LASLNETRDFFKLKRHetfe-dvnsNHEIADLLRKLYD-DPDMVEMYPGLVGHGGC----------TPY 678  Aspergillus oryzae
EFI91160   525 SREWG------TCSLNEFRHFMGLKKYdsfk-dwnpDPVVHKQAETLYK-DINNLELHVGMQAEAIKtpgpg-aglcPGY 595  Schizophyllum co...
EER41266   463 ARQWSgaqqliLLSYSSSRPVLANTRYsvggrhrlmSSANSSSLNLTKRsKTSTLTRKSLTISETSMgipt--wlkrTQA 540  Ajellomyces caps...
EEA28809   495 ARELG------VCTLNELRTLCNLRPYrtfs-emndNEAIATALKDLYG-DIADVELYRGLVAEQAKprqea-tglcAGR 565  Penicillium marn...
EAA31524   580 ARKWG------VGTLNDFREFFGMKRHttfe-svsgCVEVQNALRDLYE-HPDKIEFYPGVFCESDAsqsadpgpsdVDS 651  Neurospora crass...
EAA58704   377 GKDGM------FADKDLVKLLHDGCEKvaad--vnsDPKVAEALEALYG-HPDNIELYVGVQAEEAKkpflpgaglcPGF 447  Aspergillus nidu...
EDU45470   443 AREMFn-----VCTLNEFRVYLNLKPYdtfe-dwcsDKETARAAELLYG-HMNNMELYPGLMAECTKpagpg-sgvcPGQ 514  Pyrenophora trit...
EAT89123   372 ARDMFn-----VCTLNEFRRYLNLKPYetfe-dwcvDKDTARAAELLYG-HIENMELYPGLMAECTKpampg-sgvcPGQ 443  Phaeosphaeria no...
Feature 1                                                                                      
Q9UUS2     554 TTSRAILSDAVSLVRGDRFYTVDYTPRNITNWGFNEASTDKAVDWGHv-IYKLFFRAFPNH-FLPNSVYAHFPFVVPSEN 631  Gaeumannomyces g...
BAE66487   540 TISATILADANTLVRGDRFYTVDYSPVYLTNFGFANTVPDFAVAQGGl-MYKLLLRAFPGW-YTPNSVYTLYPFTTPEQN 617  Aspergillus oryzae
BAE60972   679 TVGRAVFSDAVTLVRSDRFLTIDYTASNLTCWGYNEVQQDYDILGGSm-FHKLFQRALPNW-FPYNSLHITQPMYTRKMN 756  Aspergillus oryzae
EFI91160   596 TISRAILGDAVALTRGDRFLTTEYTPNNLTRWGFKYSHVDPDDGSVGgiLPRMLLATLPDH-YPSGSAYTHFPFLEPAYI 674  Schizophyllum co...
EER41266   541 YMLRTRSQEWTQAQASARPTPSDYNVATLTNWGMAEVQQDYDTLGGSm-FYKLIQRGLPGW-FPYNSLSVMQPMYTPDMN 618  Ajellomyces caps...
EEA28809   566 TITYVILSDAVALVRGDRFLTTELNPYNLTKWGYDEIQPDNSWSFGNvlGDKLLNRHLGEEnMPRDSIYTQYMFSTPEET 645  Penicillium marn...
EAA31524   652 ALWAAIFSDAITLVRSDRFYTLDWNTNSLTSWGMKEVTPDNDVLKSSv-FHRLLQRSFPEW-FPSTSVRFFHPFYTAQKN 729  Neurospora crass...
EAA58704   448 TISFAILSDAVALVRGDRFYTVDYSPVNLTNFGFNTAESDPDVANGGv-MYKLLMRAFPGW-YEPNNVYALYPFTIPAKN 525  Aspergillus nidu...
EDU45470   515 TTGRGILDDAVALVRGDRFLSYDFNSNTLTQWGAALLSETTPGAYGGv-LPKLLFQGLPGG-FTGTSTYALLPFYTPKAA 592  Pyrenophora trit...
EAT89123   444 TTGRGILDDAVALVRGDRYLSYDFNSNTLTQWGAALLSDTVPGAYGGv-FPKLLFQGLPGG-FTGTSPYVLLPFYTPEAA 521  Phaeosphaeria no...
Feature 1                          
Q9UUS2     632 KLIFEGLG--AANKYSWDPP 649  Gaeumannomyces graminis var. graminis
BAE66487   618 RKIFEKCK--TADDLEFVRP 635  Aspergillus oryzae
BAE60972   757 EQIAREIG--TIDEYTLDDP 774  Aspergillus oryzae
EFI91160   675 RNEMRKRGdkNLDRYTWDRP 694  Schizophyllum commune H4-8
EER41266   619 REIAMEIG--TMFQYTETDP 636  Ajellomyces capsulatus H143
EEA28809   646 TRNIKRFG--MEKVYRETRL 663  Penicillium marneffei ATCC 18224
EAA31524   730 AEYATAQG--YDKDFAIKPT 747  Neurospora crassa OR74A
EAA58704   526 KEVFEKYG--RADTLEFKRP 543  Aspergillus nidulans FGSC A4
EDU45470   593 QGIIKGNG--VLDKYDIKRP 610  Pyrenophora tritici-repentis Pt-1C-BFP
EAT89123   522 KGILKGNN--VLEKYDLKRP 539  Phaeosphaeria nodorum SN15

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