3I4H


Conserved Protein Domain Family
Cas6_I-A
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cd09759: Cas6_I-A 
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CRISPR/Cas system-associated RAMP superfamily protein Cas6
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas6 is an endoribonuclease that generates crRNAs, predicted subunit of Cascade complex; RAMP superfamily protein; Possesses double RRM/ferredoxin fold
Links
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Statistics
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PSSM-Id: 187889
Aligned: 7 rows
Threshold Bit Score: 306.63
Created: 13-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3I4H_X        10 SRFLIRLVPEdkdrAFKVPYNHQYYLQGLIYNAIKssNPKLATYLHEVkGPKLFTYS-LFMAEKREHPkglPYFLGykkg 88  Pyrococcus furi...
NP_068913      1 MRLKISLLSPa--dSFEIDLNHSYHLASAIYRAIEraDPSLSIELHKPdVPKFFTFSkLFIPKRKFRIegeKMVSDceea 78  Archaeoglobus f...
YP_002306708   1 MRFAIRLRPEn--ePFRIPFNHQHKLQGLIYRRIQrvNPDLSLRLHAPkVPKLFTYS-LFMAERRELAedkSSLLGykrg 77  Thermococcus on...
NP_247349      5 MRIELELQTDn---FTVIPYNHQYYLASAIYNKIHsaNPAYAKRLHNYqKFKFFTFSlLQIRKRVIRKegiETIDGk--a 79  Methanocaldococ...
YP_001272743   1 MRLEIILKGKn---NFKVPFNYNHILSAIIYNKIA--DLNFANELHSSkSFKFFTFSqIYIPKRRIVKdgiIAKDGv--i 73  Methanobrevibac...
NP_618547      1 MRCRVSIRKIs---PYPLHYDYQYGLASMLYSKLAtsNVELAAKTHSKqGFKFYTFSnLVLDDRIPEKnglNFKTA---- 73  Methanosarcina ...
YP_002959773   1 MRIEIRLRPVg--dDPILPFNYNYEVYRQIVEKISliSPRLAQEVEVS-HVDHFTFSrILVRKRELIPesgIRILSet-v 76  Thermococcus ga...

3I4H_X        89 FFYFSTCVPEIAEALVNGLLMNPEVRLw----dERFYLHEIKVLREpkKFNGSTFVTLSPI--AVTVVRKGKS--YDVPP 160 Pyrococcus furi...
NP_068913     79 YFFFSTLRNEVAASLVEGLLSKPEIRIc----gVDFIVSEVSVLPEreVKGREKFVTLSPIyaSTSVGENGRRriFDLYP 154 Archaeoglobus f...
YP_002306708  78 FFYFSTPIAEIAEAFIGGLLQNPEVELw----gEKFTVEEVQALAEprKLSGKKFVTLSPIavTTKRIQFGKPrsYDLGP 153 Thermococcus on...
NP_247349     80 YLYISSPNNEFIENFVAGLLEDGKLRVg----nVEFFVRKAKILPI--PKKFNILKTISPIylKTMIETEDGLktYDLLP 153 Methanocaldococ...
YP_001272743  74 SFYISSPNDFLIKSLVDGFLEDLEISFq----nQKLTIQKIEALKTpeFSSKSEFKTLAPIivRTKKEINGELk-IWDLA 148 Methanobrevibac...
NP_618547     74 HFFLSSPDPEFIRSFAEGLLLEPEFFLgnnenkVSFIIERIEVLPAvhFSDMCTFRTLSPIylKTLRKQNDKLveFDLYP 153 Methanosarcina ...
YP_002959773  77 SLYVSSHSPEVIGAIVEGFMASPSIRIg----eTDFVAEDVKPLKEprIKDGTLFSTLSPIivRTVKISNNRMkiWDLYP 152 Thermococcus ga...

3I4H_X       161 MEKEFYSIIKDDLQDKYVMAYg-DKPPs--EFEMEVLIAKPKRFRIKp---GIYQTAWHLVFRAYGNDDLLKVGYEVGFG 234 Pyrococcus furi...
NP_068913    155 KDSKFYEVILQNLVKKYVLYYk-SAPEn-lDFHMKPLNVKAKRIRLK----DTFHRCVEMVFKAEGSPELLDVGYKAGFG 228 Archaeoglobus f...
YP_002306708 154 NEPEFYELIKENLREKYVILHg-SKPPe--EFEMKVLNAKPKRFEVKp---GIFQIAWHLVFRAYGDEGLLRVGYQAGFG 227 Thermococcus on...
NP_247349    154 NNSKFYENLKNNLKKKYEAFYn-EKCDm--NFEFEVLKFRPKRMRIKn---DIYCRCSEMVFKVWGDYDLIKFGYECGFG 227 Methanocaldococ...
YP_001272743 149 PSDKFFKSLENNLIKKYIKFNnlTKTDkkiNIYSDMNFVKRKRISINkgnaTTHHRAYMMDLILEGDLDLIEFAYDVGIG 228 Methanobrevibac...
NP_618547    154 KDSKFHENLHKNLVARYEEFYg-SKIEkdfFEILNIPNFKPKRVKIE----NNYRRCSLMDFSISANPELLKFAYDAGLG 228 Methanosarcina ...
YP_002959773 153 NEPTFFDKLRKVMLLRYSELYg-STPEd-sAFKIEVIKFKPVRILVA----DTYYRGSLMIFRYWGSREIAKFGYDLGFG 226 Thermococcus ga...

3I4H_X       235 EKNSLGFGMVKV 246 Pyrococcus furiosus
NP_068913    229 SKNSMGFGMVKV 240 Archaeoglobus fulgidus DSM 4304
YP_002306708 228 EKNSIGFGMVKV 239 Thermococcus onnurineus NA1
NP_247349    228 EKNSMGFGMVVN 239 Methanocaldococcus jannaschii DSM 2661
YP_001272743 229 EKNSMGFGMIKL 240 Methanobrevibacter smithii ATCC 35061
NP_618547    229 EKNAMGFGCLDL 240 Methanosarcina acetivorans C2A
YP_002959773 227 EKTKYGFGMVKV 238 Thermococcus gammatolerans EJ3
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