Conserved Protein Domain Family
Cas8c_I-C
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cd09757: Cas8c_I-C 
CRISPR/Cas system-associated protein Cas8c
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family
Links
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Statistics
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PSSM-Id: 187887
Aligned: 36 rows
Threshold Bit Score: 428.987
Created: 23-Nov-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q72WF8         3 LQALHGYYQ-RMSadpd---------agmpPYGTSMENISFALVLDAKGTLRgiedLREQEGKklrprkmlVPIAE---- 68  Desulfovibrio v...
YP_001812653   4 WKQLYDTYEmNLKhvgqfesrwegqdftllPLSHTTQTAHVTVTVTLDGDFHsatvIEKGHGNt------lIPCTEdsan 77  Exiguobacterium...
Q5P3Y7         4 IQKLYETYE-RCAnapelt------gpqpwPIAHLVKRAHVEVAIDAEGNFR----RAQKLDRlqs--ptlIPATEasag 70  Aromatoleum aro...
YP_002538858   4 IEKLHQTYE-NNLgnianpk----davpllPLFHSTQNAQLHVVLDGQGNLLdasvVMKDDAQt------iIPATEasag 72  Geobacter sp. F...
YP_001319500   4 IHKLYDTYE-NCKsevgvart--dsktpllPLSHTIVNSNIEIVVDIHGNFR----RARNVSKsea--mtiAPCTEdsas 74  Alkaliphilus me...
YP_001278621   4 MQSLYETYE-QCAkgglvgyv-sgtkrpllPICHITIQAHIEVVIDGCGNFR----RAQLVSKdda--vtiIPATEssas 75  Roseiflexus sp....
Q9KFY2         4 LLHLYETYEaNLDqvgktvkkgedreytllPISHTTQNAHIEVTLDEDGDFL----RAKALTKes----tlIPCTEeaas 75  Bacillus halodu...
Q21RK1         4 IHKLYETYE-QCQgrdmag------eaqllPVSHAQQQAHIEIALDAQGGFK----TARLINKie----tyIPATEqsag 68  Rhodoferax ferr...
YP_867412      4 MQMLHTTYEcCKDql--------------gPIYHTTQQAHLEVVLDHSGTFLr---AHVPSSKtds--ttlIPCSEksag 64  Magnetococcus s...
Q3ARV5         4 MQRLCETYD-NAHnkvgdyn----ddaillPLYHTTMTCNIEVTLNENGEFVq---AKPSEKKki----iiIPCTEssag 71  Chlorobium chlo...

Q72WF8        69 KKgNGIKPNFLWENTSYILGVDAKgkqer-------tdkcHAAFIAHIKAYcd-----tADQDLAAVLQFLEHgekdlsa 136 Desulfovibrio v...
YP_001812653  78 RAgSVVAPYPLHDKLAYVAGDFLKyggvy------kgenaHHAYLSQLKAWve----taPYDPLESIYCYVQKgqliedl 147 Exiguobacterium...
Q5P3Y7        71 RT-AGVAAHPLCEEIGYCAADYPGlea-----------nrYSDYEKQLEQWcss---efSHPKARAIYAYLRKgllwsdl 135 Aromatoleum aro...
YP_002538858  73 RSgAKIAPHALCDTLQYVAGDYLEyggnpnk---kknesgFEPYLKGLKAWvd----ssQHRKLQSVFAYLKQgrlikdl 145 Geobacter sp. F...
YP_001319500  75 RG-NGNNPHTLFDKLQYVAGDYTSffndk------rdkkfFIEYIKLLEAWsns---eyKDEKVIAVLNYLKKerlvadl 144 Alkaliphilus me...
YP_001278621  76 RSgSKPECHPLCDKLQYLAGDFVKyggkvtsgfqrnpaepHQNFVTLLSGWns----kcLHPKVSAILKYIQKgtlmadl 151 Roseiflexus sp....
Q9KFY2        76 RSgSKVAPYPLHDKLSYVAGDFVKyggkik----nqddapFDTYIKNLGEWans---pyATEKVKCIYTYLKKgrliedl 148 Bacillus halodu...
Q21RK1        69 RVgTKPPPHPLCDKLQYCALDYPLhggk--------kpsfFNEYEGLLNAWcss---efAHSKAQAVLRYVHGgtlitdl 137 Rhodoferax ferr...
YP_867412     65 RT-SGLMNHPLADKLQYVAGDYLSfagalsekeqtkmmesHRLYKEALATWads---pqSHPTVKAIYAYVAQgrlvgdl 140 Magnetococcus s...
Q3ARV5        72 RSgDSPKAHPLSDKLQYIAGDFSHyggevts---gfkndpEEPFRQLYQQLtewseaspDKYKLRAVKRYLEKkrliedl 148 Chlorobium chlo...

Q72WF8       137 f---------------------------------pvseeviGSNIVFRIEgep----gfVHERPAARQAWANCLNRreq- 178 Desulfovibrio v...
YP_001812653 148 iqegifsatgsgelr-----wtwkeagdkppiyglvtggleGTFVRFQVRsteg-vqrqPWRDKAFFDSFITFYGTrpg- 220 Exiguobacterium...
Q5P3Y7       136 nahkifpv------------------aiedahgkktkvkdeKVFLRWRVEtpge-fcsgTWEDDDLIDAWISFDRAqnh- 195 Aromatoleum aro...
YP_002538858 146 iekkvlyadnsgqlaae-wideadappvfkiikqankkgqfEAFVRFSVEisgd-tqseLWKDASLWDSWRSYYAGlqt- 222 Geobacter sp. F...
YP_001319500 145 isekllevdens-----------hvtnkwfgdkdnkpmktsDIFVRFIVEipgd-vncrLWENTDILRKYHNHYLNtkt- 211 Alkaliphilus me...
YP_001278621 152 vkegvllidhrrlla-----kddiepekrrgtifdvlndqgDAVVRWVVEipgd-tesrVWRDTKVWDSWIDYYLNhrs- 224 Roseiflexus sp....
Q9KFY2       149 vdagvlkldenqqliekwekryeellgekpaifssgatdqaSAFVRFNVFhpes--iddVWKDKEMFDSFISFYNDklg- 225 Bacillus halodu...
Q21RK1       138 vdagilhvdandnlltrwtgsgpapelfrmltpnagerdqgDAFVRWQVWeqgn-pctaVWEDTSLQKAWAWFDAStkt- 215 Rhodoferax ferr...
YP_867412    141 vnagilpcvegsipp-----kwqgpkeetpaiykavtgmplDAFVRWRVEpapgvceiePWNDPQLIQAWIDHYLAllee 215 Magnetococcus s...
Q3ARV5       149 ieagvlhldedrkllk--kwdskgkkktdkppifesitnvnDATVGWHVEkkge-ptepLWKDKDIHKAWQAYYESrki- 224 Chlorobium chlo...

Q72WF8       179 -glcGQCLITGERQkPIAQLHPSIKggrdgvrgaqAVASIVSFNN-TAFESYGk--eQSIn-----APVSQEAAFSYVTA 249 Desulfovibrio v...
YP_001812653 221 --keGLCFVTGKQE-RLSSKHTNKIrn------sgDKAKLISANDsSGFTFRGrfdkPDEa-----ASISYQASQKAHNA 286 Exiguobacterium...
Q5P3Y7       196 --enNICIVTGATA-RIGRNHSRFLrh------pgDGAKLISVNDaEGYTFRGrftdGKNeygkqaCSVGFETSQKAHNA 266 Aromatoleum aro...
YP_002538858 223 --nrDLCMVTGGTA-GLASNHPKNIry------pgDGAKLISSNDsEGFTYLGrfttDAEa-----CGIGIEVTQKAHSA 288 Geobacter sp. F...
YP_001319500 212 --kyGLCYIQGNNM-LTTLKHQSKIrg------ngDSAKLISANDeNGFTYLGrfsdSNQv-----VSIAYETSQKAHNA 277 Alkaliphilus me...
YP_001278621 225 -gtsEICFVIGEER-TLTNNHPKYIrr------egDNAKLISSNDtQGFTFRGrfitDEQa-----CSVSLEASHKAHYA 291 Roseiflexus sp....
Q9KFY2       226 --eeDICFVTGNRL-PSTERHANKIrh------aaDKAKLISANDnSGFTFRGrfktSREa-----VGISYEVSQKAHNA 291 Bacillus halodu...
Q21RK1       216 --lkGLCMVTGVGEtALAENHPKRIrh------agDGAKLISANDsSGYTFRGrftdKTGlq---aCGVGYEVTQKAHNA 284 Rhodoferax ferr...
YP_867412    216 saprGTCMVTGQTDvLLAQSHPAKLrh------aaDKAKLISANDsSGYTYRGrflsADEv-----CGVGLETTQQVHNT 284 Magnetococcus s...
Q3ARV5       225 --npKLCFISGRSDvAPAEQHPKKIlq------gaSNAKLISSNDkKGFTFRGrfttAEEa-----CTISAVASQKMHNA 291 Chlorobium chlo...

Q72WF8       250 LNYLLNPSNrq--kvTIAD-ATVVFWAERss------paEDIFAgmfdppsttakpessngtppedseegsqpdtarddp 320 Desulfovibrio v...
YP_001812653 287 LKWLIQRQG------RSIDqRVFLIWGNQqpsl--pnplENTLSlaqlfge-----------------------keelis 335 Exiguobacterium...
Q5P3Y7       267 LRWLIARQGy-----RNGD-QAVVSWAINgt------lvPDPFAntlelfgrld-----------------lldsepppa 317 Aromatoleum aro...
YP_002538858 289 LRWLIERQGr-----RDGD-QAVVAWAVSgadv--pdpqADTFAflfggkda---------------------paspktg 339 Geobacter sp. F...
YP_001319500 278 LKWLVDIQGqkfgnpKDGQ-KIIVAWGTKnqti--pqilEDTQGgifgke-------------------------etaiv 329 Alkaliphilus me...
YP_001278621 292 LMWLIDRQGy-----RDGD-LAIVAWAISgatvtvpqptDDPIAtlfgdlp-----------------------sddksi 342 Roseiflexus sp....
Q9KFY2       292 LKWLIHRQS------KSIDdRVFLVWSNDnslv--pnpdEDAVDimkhanr-----------------------elerdp 340 Bacillus halodu...
Q21RK1       285 LRWLIHRQAy-----RNDD-QVIVTWAVAgk------dvPDPFQdslalflsaeeis-----------qadtqspptnvg 341 Rhodoferax ferr...
YP_867412    285 LRWLIEKQGy-----RQGD-LRIVAWAVDgr------ttPGILIstqellgdnvpaete--------eedellptssmgh 344 Magnetococcus s...
Q3ARV5       292 LSWLVERQGy-----NKGT-LNIVAWAVSgg------niPDPMKetapydyd----------------------dlgddy 337 Chlorobium chlo...

Q72WF8       321 hAAARMHDLLVAIRSGKRatdimpdMDESVRFHVLGL-SPNAARLSVRFWEVDTVGHMLDKVGRHYRELEIIPqfn---- 395 Desulfovibrio v...
YP_001812653 336 hTVQEGALAFSDALLGFKr------RLPKQEVNILTLdAATTGRMAILYYRTFDQETYFKRLEQWHTKYPWEYiyqdadk 409 Exiguobacterium...
Q5P3Y7       318 dTAQAFALRLKRAIAGYRa-----kLDPTSDVVVMGLdSATPGRMAITFYRELKGSEFIERIEYWHTNCAWSQnfgkes- 391 Aromatoleum aro...
YP_002538858 340 yTAQEVGVALSKKLAGYGa-----kLKPTDEVVVLGLdSATPGRMAISYYRELLGSEFLERIESWHTSCCWLQyfgkdr- 413 Geobacter sp. F...
YP_001319500 330 sTEKEFAQRLNKAIAGYGc-----dLDTKAEIVIMGLdAATTGRLSIAYYRELYGTDFLNRIKHWHSTCIWQHsykiiad 404 Alkaliphilus me...
YP_001278621 343 dTAQDVAIRLKKKIAGYRq-----eIGDRTDVVVMGVdSATPGRLAVIYYRTLKGSDFLDRIETWHDTCAWRHtyrviee 417 Roseiflexus sp....
Q9KFY2       341 dTGQIFAGEVKKAIGGYRs-----dLNYQPEVHILVLdSATTGRMAVLYYRSLNKELYLNRLEAWHDSCAWEHryrrdek 415 Bacillus halodu...
Q21RK1       342 dVGQAFSLRLNRAIAGYRa-----kLAPTDDVVVLGLdSATPGRMAISFYRELKSSNFFERLQTWHRRSAWMQnfganr- 415 Rhodoferax ferr...
YP_867412    345 sVDQSFGLRLGKKISGYYs-----qLGDLTDIVVMGIdSATPGRMSIIYYRELQQTEFLQRLEKWHSQMAWPQnfgkds- 418 Magnetococcus s...
Q3ARV5       338 nAAQAFGLAFKKRIAGYRa-----rISSTDSILVLAFdAATSGRASLTYYRELTGSDFLDRLERWYARHEWLYskpekkr 412 Chlorobium chlo...

Q72WF8       396 ----------------neQEFPSLSTLLRQTAvln---------kteNISPVLAGGLFRAMLTGGPYPQSLLPAVLGRIR 450 Desulfovibrio v...
YP_001812653 410 k----------rqvyigaPSLKDIALMTYGTRgn------------eKLIKATVERLLSCVIDERRVPMDIIRCLTQRAS 467 Exiguobacterium...
Q5P3Y7       392 -------------rfvgaPAPRDIAEAAYGRRld------------dKLRKATVERVLPCIVDSQPIPRDLVESTVRRAS 446 Aromatoleum aro...
YP_002538858 414 -------------ifvgaPAPRDIAEVAYGRRid------------dKLRKATIERLLPCIVDGAPIPRDLVESCVRRAS 468 Geobacter sp. F...
YP_001319500 405 gfdekgkakfktisfigaPSPKDIATIALGSPrensktqkkhlelkdSLLKATVERLLPCIIDGAKLPYDLVNSVVNRVS 484 Alkaliphilus me...
YP_001278621 418 rdtng-klyrrripfigaPAPADIAEAAYGRRld------------dRLKQATIKRLLPCIVDGQPLPRDLVESAIRRAS 484 Roseiflexus sp....
Q9KFY2       416 e----------fisfygaPATKDIAFAAYGPRas------------eKVIKDLMERMLPCIVDGRRVPKDIVRSAFQRAS 473 Bacillus halodu...
Q21RK1       416 -------------qfigaPSPRDVAEAAFGRRvd------------eKLRKSTVERLLPCIIDGQRLPRDLMNSTVRRAT 470 Rhodoferax ferr...
YP_867412    419 -------------qftgaPAPRDIAEAAYGRRld------------dKLKSTTLQRILPCIIDEQPFPEDLIHAVVHRTS 473 Magnetococcus s...
Q3ARV5       413 ------------gffiqvRSPEQIAKDIYEHNktedk-----ekktdDIIRSVVQRLLPCIIDGQKVPFDLVVAARNRAS 475 Chlorobium chlo...

Q72WF8       451 AEharpedksryrleVVTYYRAALIKAYLIRNr------KLEVPVSLDPARTDRPYLLGRLFAVLEKAQEDAVp---GAN 521 Desulfovibrio v...
YP_001812653 468 NPvg---------mdHWEWEKTLSIACGMVNK-------KEEMTVSLDQEINDRDYLFGRLLALADYLERRALg--qDNR 529 Exiguobacterium...
Q5P3Y7       447 NRvg---------leNWEWEKCLGIACALFKGyh----tEGSYQMALEQDRTSRDYLYGRLLAIAEHIEGRALhvagEKR 513 Aromatoleum aro...
YP_002538858 469 NKng---------ieYWEWEKALGIACALYRKrh----eKEGYTMALDENRTTRDYLYGRLLALAENLEHWAIrtagESR 535 Geobacter sp. F...
YP_001319500 485 NPvs---------meKWEWEKALTITCALVKKyky-dklKEVWEMALDENQKDRSYIFGRLLAIAQQIEEYALyttgEKR 554 Alkaliphilus me...
YP_001278621 485 NPvv---------lsDDQKEKVLTIACALYRKym---ygKEQYDMALDETRRTRDYLYGRLLAIADVIEERALykaeQNR 552 Roseiflexus sp....
Q9KFY2       474 NPvs---------meRWEWEKTLSITCALIRKmhi--eqKEEWGVPLDKSSTDRSYLFGRLLAVADVLERGALgk-dETR 541 Bacillus halodu...
Q21RK1       471 NRvg---------maHWEWEKTLGIACALFNSyf----hERDYQMTLETDRLSRDYLYGRLLALAEHIESRAIylggEKR 537 Rhodoferax ferr...
YP_867412    474 NRvafdr---sktgfQWEWEKCLGIACALVRGsnlrahiKKEYAMALEPDYTSRDYLYGRLLALADYLEEQALhaanEHR 550 Magnetococcus s...
Q3ARV5       476 KPmsfkky-kedwknREDWENTLSTACALFRGyyy-tnfQEEYSMSLDPNRTTRDYLYGRLLAVAESLEKSALgladEGR 553 Chlorobium chlo...

Q72WF8       522 ATIKDRYLASASANPGQVFHMLLKNASNHTAKLRKdperkgsaihYEIMMQEIIDNI-------SDFPVtMSSDeqGLFM 594 Desulfovibrio v...
YP_001812653 530 ATNAIRYMNAFSQNPARTWMTIQSALQPYQAKLGGkv------lfINRQIDEIGSRLt-----iEQFTN-KPLS--GKYL 595 Exiguobacterium...
Q5P3Y7       514 DTTAARLMQRFADRPYSTWKTIELSLAPYKTRLRAqr------tgFLFEMDKLLDDVtas-fpsHSFTQdSQLS--GEFL 584 Aromatoleum aro...
YP_002538858 536 PTNAERMMQRFADRPYSTWRTLELSLLPYKVRLGD----------KAHKVKSLLDAVhvkfdppEEFTRdDRLS--GEFL 603 Geobacter sp. F...
YP_001319500 555 PTNAERLMHQFKLHPYKTWGIITDKLGPYIARLGS----------KGTGLTELMTQVnsm-ipyEEFTSpKKLD--DSYI 621 Alkaliphilus me...
YP_001278621 553 PTNAIRYMQQFSQRPFRTWKQIHDLLMPYLMRLGGra------yyYKNLIAEVESMFt-----pEDFVStRSLS--GEYL 619 Roseiflexus sp....
Q9KFY2       542 ATNAIRYMNSYSKNPGRTWKTIQESLQPYQAKLGTka------tyLSKLVDEIGDQFe-----pGDFNN-NPLT--EQYL 607 Bacillus halodu...
Q21RK1       538 DTTAAKLMQRFADRPASTWRTIELALTPAKSRLRAkq------agFLHKMEVLHDGIvas-fqgDDFLDdRKLT--GEFL 608 Rhodoferax ferr...
YP_867412    551 ATNAARLMQRFSQRPNATWLTIYDALLPYKNRLQVnkpg--lyinMMRELDNVMNLFa-----iADYQNdAPLK--GEYL 621 Magnetococcus s...
Q3ARV5       554 SSTAERYMQQFAERPFNTWKTIELSLSPYIARLQSnapg--lkkfYTDKLDEIHCLFn-----pDDFENnEPLT--GEFL 624 Chlorobium chlo...

Q72WF8       595 IGYYHQRKALFT 606 Desulfovibrio vulgaris str. Hildenborough
YP_001812653 596 LGFYSQRHELYQ 607 Exiguobacterium sibiricum 255-15
Q5P3Y7       585 LGYHCQRQALRP 596 Aromatoleum aromaticum EbN1
YP_002538858 604 LGYHCQRAALKP 615 Geobacter sp. FRC-32
YP_001319500 622 LGYYCQRQVFID 633 Alkaliphilus metalliredigens QYMF
YP_001278621 620 LGFYCQRQKLLE 631 Roseiflexus sp. RS-1
Q9KFY2       608 LGFYSQRRELYK 619 Bacillus halodurans
Q21RK1       609 LGYHCQRRELNS 620 Rhodoferax ferrireducens T118
YP_867412    622 LGYHCQRAVLWA 633 Magnetococcus sp. MC-1
Q3ARV5       625 LGYHCQRLKNYE 636 Chlorobium chlorochromatii CaD3
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