Conserved Protein Domain Family
Cas8a1_I-A
?
cd09730: Cas8a1_I-A 
CRISPR/Cas system-associated protein Cas8a1
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-A subtype; also known as TM1802 family
Links
?
Statistics
?
PSSM-Id: 187861
Aligned: 16 rows
Threshold Bit Score: 379.787
Created: 23-Nov-2009
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
A0B6V4         5 VIEAVARIGKQRIGehaqsgcEDILYYIVEnpn---------lngGYNHALVVTLEEKDGDFSyr--gvELEELKDYRRY 73  Methanosaeta th...
YP_002509269   1 MINSFKELGEIELQgls--dsEKKQKFLETqtiipnepdsgdkdaDKYREVIINLDTEKEEIEikl-gkELYEKNREEFF 77  Halothermothrix...
Q3AA63         1 MLEAVREVGRLATEhasggflENLCLEIDEdq-----------ggKKQHVVIIDFATANNSLKit--pkEITPGVTEREY 67  Carboxydothermu...
YP_001410444   1 MLEGIVQIGRALLEnks--liDSLIKELPAkdk----------kgNLYHVLKLKFSKENLELDv----sEEIDSDTARKY 64  Fervidobacteriu...
YP_001664131   1 MITAIKELGEMVLKsq----nKTLLDVLIEnpn---------qdgRYSKIIAINFIVKEDEIEyegirlEEYDDSKISRY 67  Thermoanaerobac...
YP_001178902   3 LIEEIVEIGDVLIGdas--gnDAHLSVLTEdiev-------psgdEKRYVAKIDFSTNEKKINid--caEEIDDETAKKY 71  Caldicellulosir...
YP_001469840   1 MLTKIIKIGKLYQQee---lfENFAKTFKS---------------NLLVALYFDLGPPVQYISs----hIIEPPENLQKL 58  Thermotoga lett...
YP_001663922   4 IIEGIVQIGDIVREnd---pvKNIIVELPYkk-----------gdNALHVLKFNFLPEENKLEid--vnEEMDEGTVFKY 67  Thermoanaerobac...
Q1AZD1         1 MIESIYQIGRAILEegg--grRTVLESLADsppa--------dgkGKSYIAILKLDTARWKLGvel-reLGGEKNTAARY 69  Rubrobacter xyl...
YP_001097296   1 MITSFRKLGAEKLNgls--paDRKLEFLKFqtivp-----ktipeKTFYEIILNLNTSTNEIEikl-gkELSEENRFDFM 72  Methanococcus m...

A0B6V4        74 LYKGKKGNat---dATPTCKIAKdiek----------------------tfekKFLRwfdgidssdl------------- 115 Methanosaeta th...
YP_002509269  78 GFDLKASNss--ktYFTTDNYNYhlltiphliy-----------yiekeidklKIKNiedfldwlnmiknkfyivvgrdy 144 Halothermothrix...
Q3AA63        68 LWVGNADGssspqwYLSTNNLSFlvsqtlpnl-------------levlpegsKLAQnvqkvldlyffdtgvkegaenry 134 Carboxydothermu...
YP_001410444  65 LYIGTADGpnapqwYAANNKITYflsetlfnlt----------nidfgeplnqKLKHifekfyvdlgpgikskyryalnl 134 Fervidobacteriu...
YP_001664131  68 LFTDTGGNap---gYTPAAKITEvpkt-----------------------fngKIKNwfnkvlkdksik----------- 110 Thermoanaerobac...
YP_001178902  72 VYVGSAEGanssqwFASTTSFAYfltetipnlveceipvvsdickkildmyfvKVKEylsksselideekrylqqriekk 151 Caldicellulosir...
YP_001469840  59 LYYDQKGNvs---gKSPTVSITFkned-----------------------gseKIRKgvekailklk------------- 99  Thermotoga lett...
YP_001663922  68 LYVGKILGnsp-lwYASSTSSDYiltetiynlt----------kmdfgeelnkKLKDifekfyvsieelepkyryvldls 136 Thermoanaerobac...
Q1AZD1        70 LWLGNAPAamddqdRLTTNNLVYlvsqtipnllme-------grldpasalygKLKRlkdelyldlgepselgtkgggay 142 Rubrobacter xyl...
YP_001097296  73 GFEIPVKGnpk-kiYFTTNQLRYlditv--------------------pqmieKIEKdfkkskeydefkkyllnikdtfc 131 Methanococcus m...

A0B6V4       116 ----------------------------------------------------sgeeratlknIKNVLFSNKDKIFKElqe 143 Methanosaeta th...
YP_002509269 145 fgrpisylsvdknvshqkkeivkylrseidkyekrgnaekakeinkyingevvnteiltikdIKKYYEKQISLAISTtq- 223 Halothermothrix...
Q3AA63       135 ryi---------------------------------lnlemlpgykgsklldlikenpkgknLAQAVAKEFSKWIKDqt- 180 Carboxydothermu...
YP_001410444 135 yy------------------------------------ldpnvdvrklyeeyskqnqgndkgFLKVLEKQFEKILFEny- 177 Fervidobacteriu...
YP_001664131 111 ---------------------------------------------------idekdraflerIKDILEEKSDEIIKEaek 139 Thermoanaerobac...
YP_001178902 152 yvyfldtdni-------------------vvndnkrltekplsqiykelinnakstdkifkqLRDVFTKECTNGLKKlt- 211 Caldicellulosir...
YP_001469840 100 ----------------------------------------------------sffkhpmlkdFENCINDEFESIVLDvek 127 Thermotoga lett...
YP_001663922 137 ksgyk-----------------------------eksvqdlfkeikedkknenlspneigkkFRKKVSKYFEGYLKKek- 186 Thermoanaerobac...
Q1AZD1       143 rryryf----------------------------wdvgrlgiegpgleelrqevreglrpgnVPQKVARALQSHFRQe-- 192 Rubrobacter xyl...
YP_001097296 132 teki-------------------------------ridkgkekkycgldfeklqnnikleigKEQVSIKDIEEYCKKvqt 180 Methanococcus m...

A0B6V4       144 k--------rshlKQRENCIITLGFVKDgdlk----yladYPAFRNVLLKnscdrff-rkyggeSRGTDAl-----CSVC 205 Methanosaeta th...
YP_002509269 224 -----------nfLKNELNIFSIHINGKriles--iykapYVEVVYYILQqrffdt--snsdkmARDNAL------CGVC 282 Halothermothrix...
Q3AA63       181 -----------glSEKEVALYTIYFDGQkg--------vdYREYQEKVEAakvf-------difAGEEGV------CHAC 228 Carboxydothermu...
YP_001410444 178 -----------eaKLNEFGLFVIYIDGEpl--------skYEEYRRKVLEykssgeksetsskkEKSKDLr-----CNIC 233 Fervidobacteriu...
YP_001664131 140 ir------gdfpkKEGLSLILKFNVDGEyky------igdFNVFRDLMLQld-----------sQKYQKIyaedkvCSIC 196 Thermoanaerobac...
YP_001178902 212 -----------elKPQQIGLYVLCVDGKpl--------tsYPEYIDAVIAykrqvkkgtektkkKQKEGNi-----CYIC 267 Caldicellulosir...
YP_001469840 128 l--------ltdqKNLKGVYLTVKLLRHdselfpsehgefVKAFIDNILKks----------veGGEEGI------CTFC 183 Thermotoga lett...
YP_001663922 187 -----------niEPEEIGLYTVFIEGKpl--------ssYKEYVDAVIEskkp------ktqkTKKAGIsr--gvCSIC 239 Thermoanaerobac...
Q1AZD1       193 -------------IPERGVLFTLELDGEllvd-----dpaYQEYLERSLIgrv--------fegAREEGV------CHLS 240 Rubrobacter xyl...
YP_001097296 181 enypdlksskkseLKTYVNIYSLKIDGKsilet--gfkedYVNIVDYTLKeryf-------dkaELKKGI------CGIC 245 Methanococcus m...

A0B6V4       206 K-EQkDEVYAYai---pWPFHTFDKPGFIAggfrqSDAWKn-TPVCLNCAINLDAGKKYIEESLDFSFY-GFR-YLLIPK 278 Methanosaeta th...
YP_002509269 283 N-EN-KLITGKid--ipTKFYVTSSPYFYEnl-erKNAYKs-FGICQDCYLKVMAGIAKVKKDFSGKLFnQLD-YYVIPT 355 Halothermothrix...
Q3AA63       229 G-NF-GPITSDttk-lkFKYYITDKIGYASnh-dkKNFYKn-YSLCPECYKKLLIAESFIQNKFNNRLG-NLN-LFIIPG 301 Carboxydothermu...
YP_001410444 234 G-ST-ENLTDDlkk-mkIKYYTNDKITFASel-dpNKFYKn-MVICQNCLNAILAAETYLDNKLKTKLG-DLS-LYIFPH 306 Fervidobacteriu...
YP_001664131 197 GqKK-DIVFGTvd---tYKFYTIDKPGYIAggfneKESWKn-YPVCAECRLALEEGKRYLENELTFRFY-GLE-YQLIPN 269 Thermoanaerobac...
YP_001178902 268 L-DT-DNLSFEgfkktkFKYFTTNQNIFASyl-dqKNYAKn-ITVCEKCLLKLVAGDIFLRNKLKTQLG-SFD-VYVLPT 341 Caldicellulosir...
YP_001469840 184 G-RK-KIVSATvn--evFKFATFDKPGFCPsl-kkDDSIKv-LPICDECKSQLQNGANKVIQELSFNFLkNQNpLWVIPS 257 Thermotoga lett...
YP_001663922 240 G-SQ-DAIAFDssk-vkFKFFTTNQIIFASsl-skNNYYKn-MQMCSECFSKYQAGENYISNKLSTKLT-AFD-VLIIPQ 312 Thermoanaerobac...
Q1AZD1       241 G-RK-GPVTTDitr-frFKYYITDKVGFASga--tKKGFGsnFALSREAYTALLVGERFVRRELGFVFA-GAR-GYMIPD 313 Rubrobacter xyl...
YP_001097296 246 G-TE-SDITGKid--ipLSFYITDNKYFFEnl-teKNKHKs-FSICKNCFEELRIGISEIQKNFGGQVAkGIS-YYIIPK 318 Methanococcus m...

A0B6V4       279 LIig------ddYQEILDILSgmkkelk------msrktrnRITDDEDEIldmvkd--qkdffsNSLMFY---KKDNsAY 341 Methanosaeta th...
YP_002509269 356 NIayc----kkyKTEIEVIKSilsdnn---------ksfkkNIEAINSIAnsn---------lkVNFLFWfkpKGQNaAF 413 Halothermothrix...
Q3AA63       302 FLfpv----nlkKQQFQKWMEftnnsfn-------nlkgysEIAGYEEMVsdyfenrkiynqliFNFLFY---QKNKaEF 367 Carboxydothermu...
YP_001410444 307 FIyge----plnESELDLVVDkiinsyn-------ivknlkGVQEFEEKIlgitde---nryflVNFLFF---KKSQqAT 369 Fervidobacteriu...
YP_001664131 270 FIigk----efvRKEVREIFEsserlls------lkrevkkRFIGDEDEIldylad--aedsmtVNLLFL---RKSNsAE 334 Thermoanaerobac...
YP_001178902 342 FVytsa---kltKNYLEELSQnitnsln-------tawnynSLEKLRDDIynflsyfdqnhyflLNLIFY---REAQaST 408 Caldicellulosir...
YP_001469840 258 IIee------nsEEILKNVIQriadt----------skklkDFANSEREIelvlse--ekstvhYDFLFM---ELNQnQQ 316 Thermotoga lett...
YP_001663922 313 FIhgkpiskydlEIATDKIIDsfntv-----------ksyeGIERLREEIgtsldltdeksyflLNFIFYe--IDSQ-AT 378 Thermoanaerobac...
Q1AZD1       314 LYtvev--pkglPGALQRVLRgirsrtl-------ftlgrvQEEDLDEELedfrreh-lasgymINLLFY---RQKQaKF 380 Rubrobacter xyl...
YP_001097296 319 NNysd----pnfKKVCKKINDklqgtsssvngkfneirdikRVEYKNEDFv-------------LDYLFY---TQDKaKF 378 Methanococcus m...

A0B6V4       342 RILLHIDGILPSRLRRLFEAKERVEGAFGiynemvlsedkgrlIFDFGVLRRFFpre------sgnVTHDKMFLeivNRI 415 Methanosaeta th...
YP_002509269 414 VVSESINDVAYNHISQIIKNLYNLNMKLIypnky-----fnlyKLTFNDIYWLLfpnteshknpdpKLYRKELLsllNSI 488 Halothermothrix...
Q3AA63       368 KVLKLIKDIPPSRILKILQLFQKVNEVYKkhfnq----llpelSLNLNRIYYQIpqqk-----gknSVEYRKFLdllESI 438 Carboxydothermu...
YP_001410444 370 KIRRFIKDVPPSIFDRIAEASKCAREIVKkaiqm-----nyetYIDLQKIYYLIpvkv----sageVTEYKYILdfyESL 440 Fervidobacteriu...
YP_001664131 335 RILLLIEDVFPSHLREIFNAKEQVDKIFGn-------------SFTFKNIRSFMsksds---nkrdNDLDGYFLditDRI 398 Thermoanaerobac...
YP_001178902 409 KIIRFVPDINPSIFDKIYNAASKVFSQYTdlign-----dpsfKISLESIYYSVpirlk---niseSKEAQRLLniyDAI 480 Caldicellulosir...
YP_001469840 317 RIELHLTEISPTRLKKIVQSIDDSKRRIKidd---------lpEPSLGMLWKLYekp------sgsDKSRKDYLalvKSI 381 Thermotoga lett...
YP_001663922 379 KILRLIKDVDPSIFERVRIALENANKDVKeilge-----kykgTITLSTVYYINpiri----kdgkAVKYRDILeiyDAI 449 Thermoanaerobac...
Q1AZD1       381 EVLGLIQDIPSYRLEELRSQGRRTGRLWEelyg------searDLTLQQIYYLIpvrk-----sgdDMLTKEILafyHAL 449 Rubrobacter xyl...
YP_001097296 379 TVLENITDVSYSRMEFIFDELKRLTNEELysk---------liEVVFNHVYVLLfpnklshtkvdsKLYQKEFLslfSSM 449 Methanococcus m...

A0B6V4       416 FVGRYVDRHLLISFMMKRIRDDFVhg---------------rSTLMNTLNGFMLLHYLKELNLLKdlevdrmsgivlkre 480 Methanosaeta th...
YP_002509269 489 LKGRSVNYNYLIKQFNFILRKRYFknsk-----------rveEIIYNPMKMNLLLTWLNEITEIKggfkmseg------- 550 Halothermothrix...
Q3AA63       439 FTGHPVEKSFIIRQHIELFKIFAFtkegfnvnp-gsekykeiELAKACLRANLLNLFLQELEILPkeveave-------- 509 Carboxydothermu...
YP_001410444 441 LTFKPIEKETLIGKFIEATKVIYLqkngy--------ninkdSLEFYILNANMLVKFLEKMGNLKegntldt-------- 504 Fervidobacteriu...
YP_001664131 399 FRGRPVDLGFLYNLIMKKIREEFVkd---------------gYYKAATADGLMTIAFLEKMKLIKmevi----------- 452 Thermoanaerobac...
YP_001178902 481 FSGKRIARDVLIENFIKAVGVVVYgkegynl-----skfignDIASMVIRMVFVIRFLEILDCLEvergmdv-------- 547 Caldicellulosir...
YP_001469840 382 FQEEPYSYSRLLWYFMRKIRKSAIte--------------gaWWRKLTYVSFAAILHLNQINVLNlrrge---------- 437 Thermotoga lett...
YP_001663922 450 LTGKNLSKKHIINNLVDGVRIIKFkkggyn------iipekrYIEFYLLEASMYVKFLEYMGCLKegerldv-------- 515 Thermoanaerobac...
Q1AZD1       450 ISGGLIDRKGLIDGFLELIRAYRFrntaayqvsapeegqedlAVTRYVAQTSLLLAFLRDLDQLKeeevdqgy------- 522 Rubrobacter xyl...
YP_001097296 450 INGRAINYDKILRNFNYIFKKYYFntey----------nndrRLRERHIQMNILLTWFNKISGFTggfdnmvd------- 512 Methanococcus m...

A0B6V4       481 elealpldKRVERFFeanr-effDSDAKKATFLEGVLVQKLLNIQw-------MEKNa--KPFYTKLHGLKMNEALIKRL 550 Methanosaeta th...
YP_002509269 551 tssipienSDIKEFFsthaetykNNKYRQGLFLLGVLMNEVLKKQ--------QKENk-sASILDKLSFDGMSVRQVSKF 621 Halothermothrix...
Q3AA63       510 --leldlkAEDLEYIrd----mgYTPQQAALFLLGVLVGEIASAQ--------HQSNl-nKAILNKLTYQGMSLRRIISF 574 Carboxydothermu...
YP_001410444 505 --sklnvrEDIKNYIst----mgYDEQQSAMFLLGILIGEIGNSQy-------KKYNsdkKPILNKLNFNGIDKSKIIKI 571 Fervidobacteriu...
YP_001664131 453 ----pmeeRIFDSFFakyg-ptfEMPLKRGLVLLGALTELLLRKQy------sDREA---KPFMKNLKGLKMDEKDIKGL 518 Thermoanaerobac...
YP_001178902 548 --aqlnlsEDLKNYIqq----mnYDEPKTALFLLGVLIGEIGAKQylat-kdrQDDSaghKPILNKINYNGIDKPKLIRL 620 Caldicellulosir...
YP_001469840 438 ---yivssSEIDQFFnsyp-effNLPWKKAVFLTGVLAGKVLSVQy------aKRQA---TPFFKKFKGLKMNMQDVMGL 504 Thermotoga lett...
YP_001663922 516 --sqlkidENIKTFIsn----mnYNEQETAMFLLGYLIGQIGNVQykkaqkgiQDEGtpnKPILNKINFNGLDKQKIIRL 589 Thermoanaerobac...
Q1AZD1       523 -ldclsldEEEKEYLrr----lrYDKQQTALYLLGALVAEIANAQwrl---gpEGRGg-eKTILNKLNYQGMTLPRIQRL 593 Rubrobacter xyl...
YP_001097296 513 tsaipiedKDILEFFrihediysNNTYRQGLFLLGYLINKILLEQ--------NDKS---GNFMNKINFDGIPSKRVHRL 581 Methanococcus m...

A0B6V4       551 LPEIQNKLEEYEkn------------yyRELEAIIAEHFvlsgRGWKETDDELSFYFVLGMNL 601 Methanosaeta thermophila PT
YP_002509269 622 VNDITEILHIHDkyt-----------cnQLLHSQMIDRIqg-iENSSLNKDEVVFYILSGISF 672 Halothermothrix orenii H 168
Q3AA63       575 ANEVHQKLFQYKkln----------pgtEKIYNSMKKLLdreiPRWSLSEQENVFYLLSGYSY 627 Carboxydothermus hydrogenoforman...
YP_001410444 572 ANEVYAKLEQEKirk-----------yhETTYAEMKRLLdenlKNWKLNKNENLFYILSGYSY 623 Fervidobacterium nodosum Rt17-B1
YP_001664131 519 LPKVQNKLEEYDsfe----------kgkRLLAKEASNYLllagDNWNMSVDEINFYFACGINL 571 Thermoanaerobacter pseudethanoli...
YP_001178902 621 CNDVHNKLRQEKilp-----------ytEMIFAEMKRLLdkhiDSWKLDKYETLFYILSGYAY 672 Caldicellulosiruptor saccharolyt...
YP_001469840 505 LADIRNKLQQYDayg----------kksDELLKTAAEYYlq-sSKSNTTIDELNFIFTLGLAY 556 Thermotoga lettingae TMO
YP_001663922 590 TKDVFNKLNQEKilh-----------ynEVTFYDMKRLIdsniRNWKLNKDESLFYVLSGYSY 641 Thermoanaerobacter sp. X514
Q1AZD1       594 ATELFDKLRQYRytdrsgerrpllqgrnESIFAQAQELLteewGSWRLTPPENVYYLLSGYSH 656 Rubrobacter xylanophilus DSM 9941
YP_001097296 582 ILDVTEYLSIYKiys-----------enNGVYSQMVDRLqg-iDNSELKGDEIVFYVLSGVSF 632 Methanococcus maripaludis C5
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap