Conserved Protein Domain Family
Cas8b_I-B
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cd09691: Cas8b_I-B 
CRISPR/Cas system-associated protein Cas8b
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-B subtype; also known as Csh1 family
Links
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Statistics
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PSSM-Id: 187822
Aligned: 7 rows
Threshold Bit Score: 264.705
Created: 6-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
YP_360971    236 SDTTKLKFKYYITDKIGYASNHDkkn----fyKNYSLCPECYKKLLIAESFIQNKFNnRLGNLNl--FIIPgfl------ 303 Carboxydothermu...
YP_002250042 241 YDTTKFPVKFYITKLITFSSDFEgkgvkkgfsKNFSLCRDCYKDIILGIKFIQNNLDtRLGNNDl--WIIPglffn---p 315 Dictyoglomus th...
YP_002728850 186 VFTTSEIYKFYTLDKPGYIAGGFnks---nawKNFPVCESCYLKVDYGRKYIEEHLEfNFYGKTy--YIIPnv------- 253 Sulfurihydrogen...
NP_229599    176 NSRLSDVFKFATFDKPGFTPFLSk-------kHPIQICDDCRSVLEKARRAIDEKLSfSFFSNNrilWIIPsvp------ 242 Thermotoga mari...
NP_632588    164 TLYDSIVYKCYTNDKEIFSNTDG---------ISYGICKDCIFDVLYGRKHVNMFLStWWGGSEi--LFLP--------- 223 Methanosarcina ...
NP_782088    173 SKEKEYLKIFFKYDLDKYRKESEk-------yISPNLYNSNDYNVKIKEEIYGLPND-NMGLNSkkpYLEN--------- 235 Clostridium tet...
YP_134127    251 VGTSEDPQNYYLGKQLEKFPGLDiee----awRTHPISEDAAVTVMNAGTFVEACTYrTFGTKV---YCLPyvwgtists 323 Haloarcula mari...

YP_360971    304 fpvNLKKQQ------------FQKWMEFTNNSfnn-----lkgYSEIAGYE--EMVSDYFENRkiy----nqLIFNFLFY 360 Carboxydothermu...
YP_002250042 316 lgkELKESW------------IRTSREFVKSTf---------nLQEFLSFE--ERIQRNLDEYrefeeiadyGTVDLLFY 372 Dictyoglomus th...
YP_002728850 254 -ilNTKEVMneyld---ilseAKKRVSLKDKN-----------PTEDENYI--INLLKDHKDG---------LCFYFLFL 307 Sulfurihydrogen...
NP_229599    243 -dqDILESV------------IEKIYEIKDTDkn-------skFRSFARLE--EEIEKVLSENe-------rAVYDFVLI 293 Thermotoga mari...
NP_632588    224 ---HTYNEE------------VKEIFEFSKIGd----------LREGKNLL--QQIRENECDVinei-gkcgTDVDILFY 275 Methanosarcina ...
NP_782088    236 ---KTRKSKvpyliskeevliQKKFFDYLMNQvaigksniyinEKGIKGISnkETLGEDFTGYy--------LRIQKGKE 304 Clostridium tet...
YP_134127    324 dafDLYKLLydatteddgmtpIERQYENRNTLfgd------aqLRFYVSAVmpHQMSRYDVFGe--------TLNGRLLY 389 Haloarcula mari...

YP_360971    361 QKNKAEFKVLKLIKDIPPSRILKILQLFQKVNEvykkhfnqllPELSLNLNRIYYQIpqqkg--knsvEYRKFLDLLES- 437 Carboxydothermu...
YP_002250042 373 ERSKEAFKIKEYIKDVHLRRVEKIRNSIREVENlgrei-fgegENWFLGLEDIYFLIpirr---gkvsEYKKMLDLYED- 447 Dictyoglomus th...
YP_002728850 308 KKENSAERILLLIEDVLPSRISKIFKVKKEVEKif------niENYNFGFLTQFLGN-----------YDKIFFEVIDK- 369 Sulfurihydrogen...
NP_229599    294 EKEQQAERIVLHVEEVSPTRVRRILEESKKIESqlke--dgfkVSVNFSVIHKFFED-----------LDRYFNSLFSA- 359 Thermotoga mari...
NP_632588    276 SAQKSEWKITYNIKDVIPSRFSKIAELEHKYQSks-------gENLALWQVLAYLLGnsskp--seifNTNEAKNFLKN- 345 Methanosarcina ...
NP_782088    305 VEIHNFDTIVNYRAKIEPFKLENVLELEKSELNynvf--iyeiGKLKDLIDNVFFYKflsg----nffTKAEDLNINDAt 378 Clostridium tet...
YP_134127    390 PKELATKHNQLVQQSAAFHSGAEWTPPMPTHPNwdll--agsdEQLHAVSTGWYFAQtfaqrddddadADDPRIEALVS- 466 Haloarcula mari...

YP_360971    438 IFTGHPVEKSFIIRQHIELFKIFAFTKEGfnvnpgse-kykeielAKACLRANLLNLFLQE----LEILPKEveave--- 509 Carboxydothermu...
YP_002250042 448 IFLEHRIDKDILIDYFVDLAKVYRFEKFSqynikmv--kntdmgmSLSILKTNLLLKLFEK----LNLITGGdrmpe--- 518 Dictyoglomus th...
YP_002728850 370 IFRGGKLDFQTLLQIFTKKIRDEFLSGNSi---------------TNTVIYALMNVRFFEE----LGLLESKegk----- 425 Sulfurihydrogen...
NP_229599    360 VFSEGTFDKKLLLTLFLSKIRSDFFGNDT----------------LLSAREAFATYVYLRR----LNVLKGGas------ 413 Thermotoga mari...
NP_632588    346 IFHGNKINRNLFFSRSMSKYKHDYFEGYEnm------------fmLHRTYNFLVDCGCLDKgwcfVEQTSRGys------ 407 Methanosarcina ...
NP_782088    379 LKRSILLSRDTLFTWFYKGVDNNTWNNLNisslnlikgsinkrylLKAGEQFNLRCSLKNYf---EGGISMAdvll---- 451 Clostridium tet...
YP_134127    467 VLSGDAISVETLLEEYVARIITEQTDDDVegfpsfr--vasqfaqLCALATDKLDLLTSDDa--aKEPITREptydtqtm 542 Haloarcula mari...

YP_360971    510 ------------leldLKAEDL--EYIRd------MGYTPQQAALFLLGVLVGEIASAQHQSNl------NKAILNKLty 563 Carboxydothermu...
YP_002250042 519 ------------faddVLDKDLq-EYISk------MQYSEEEAALFLLGYLIGEIGYEQIRGAdl---saKKPILNKInf 576 Dictyoglomus th...
YP_002728850 426 -------------mekTKFDEIy-EKVGk------SLNTPAKRGIFLLGALTQMLLDIQWSERk------TTPFFKNLkg 479 Sulfurihydrogen...
NP_229599    414 ---------------vLKGEDFfsRYPE-------FFDEPWKKAVFLEGVLANYLLYLQYVKRn------SKAFTKKLkg 465 Thermotoga mari...
NP_632588    408 ---------------mVKYEDLe-EFFDfn---kgFFDSNIKKAWFLLGRLYGKMIQESKSYKggedkqsNESHLEKNff 468 Methanosarcina ...
NP_782088    452 ------------evknSLREKIn-KTVKenknhedVTLDNDREYYFAVGQLAYYLISLSKSKNk------SHSLVNPI-- 510 Clostridium tet...
YP_134127    543 epptdilaadgghpaaAKLESFi-EDTPalapdedAPHNDQRRGAFLLGALVGEIGSYQEYDQd-----rSTTLVDQFpv 616 Haloarcula mari...

YP_360971    564 --qgMSLRRIISFANEVHQKLFQYKKLNp--------GTEKIYns-mkKLLDREIP----RWSLSEQENVFYLLSGYSY 627 Carboxydothermus...
YP_002250042 577 --ngISAKNLINLANEVFEKLDQYKIRG---------YNEKTF-----SVMKSLMDkhikSWKLSEQENVYYILSGYAF 639 Dictyoglomus the...
YP_002728850 480 --lkMNEEDIKGLLPKVVNKLMEYERYDk--------GKQELAq----EISKNLLSq--eKFGLSINEINFYFVSGMAL 542 Sulfurihydrogeni...
NP_229599    466 --lrLTKRDVEGLLPEIRAKIEAYGGMSe--------SVAELFr----ETAEAFLEa--gNWSASPDEISFVFVSGLSL 528 Thermotoga marit...
NP_632588    469 fgrkYDFKTFVYFSNQCSELMYKYGVQNk-------gYLKDLI-----STSKELMGa--gDSKLSSDEAKYIFFWGMQQ 533 Methanosarcina m...
NP_782088    511 ----INAKTNERIKDEIRRLYTRYNYRIe--------FGSKRVer-lySMISSYVP----KGKINGDLIIAGFLKNNLI 572 Clostridium teta...
YP_134127    617 --ksITKSRIKKVTQETIGKTLTYTRQEkkagqsypgTKAEHVverlrETILKPDPd---EWDLDTDDLRFYYALGVTY 690 Haloarcula maris...
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