Conserved Protein Domain Family
Cse1_I-E
?
cd09669: Cse1_I-E 
CRISPR/Cas system-associated protein Cse1
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; subunit of the Cascade complex; signature gene for I-E subtype; also known as Cse1/CasA/YgcL family
Links
?
Statistics
?
PSSM-Id: 187800
Aligned: 12 rows
Threshold Bit Score: 331.311
Created: 5-Feb-2010
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
BAD59278       9 DLLDEPWIIVTdasg----kasEVSLRQVFRRad--eYVAIGGe---VPTQQFAILRLLLAILHRTVad---rPGTAIDV 76  Nocardia farcin...
AAL21823       5 SLLTTPWLPVRfkdg----stgKLAPVDLADEn----VVDIAAt---RADLQGAAWQFLLGLLQCSIa-----PKRYKNW 68  Salmonella ente...
CAE13041       2 NLVQDPWLPFRlrd------gsEKVLPINAICdh--dVMDFALp---RADFQGAACQFAIGLLQTVFa-----PEDKYQW 65  Photorhabdus lu...
Q46901         2 NLLIDNWIPVRprng---gkvqIINLQSLYCSr---dQWRLSLp---RDDMELAALALLVCIGQIIAp-----AKDDVEF 67  Escherichia col...
AAR34761       2 NLLTEAWIPVRplpa---gaacKLTLRQLLCEd---gRWELCLp---RDDMELAALQLLICMTQVFFp-----PQSTAAL 67  Geobacter sulfu...
BAC75253       7 NLFDEPWIPVRwthaaplphpeRVGLRDLLLR-----SGDIATltiaDPPAHSALLRILYALTARVTgldesgPGDWGER 81  Streptomyces av...
tigr:CT1972    6 NLIDEPWIPAI-----------GKGLVSLADIfsdprIPALGG----NPVQKIALTKLLLAIGQAACt-----PETTEAL 65  Chlorobium tepi...
tigr:MCA0935   2 NLLTDPLFRVEtpd-----gieRLSLPQLLEAlg-qdRVESLLg--lQRHQEDAFHIFLCYLAGAVLar--eaRSEPRQP 71  Methylococcus c...
NP_289309      5 SLLTTPWLPVRfkdg----ttgKLAPVDLADEn----VVDIAAp---RADLQGAAWQFLLGLLQSSFa-----PKDYRRW 68  Escherichia col...
NP_457332      2 DLTKEKWLPVIfsng----dkkKISLRDLLDNr----IQDLAYp---RADFQGAAWQMLIGILQCTVa-----PEDKEEW 65  Salmonella ente...
YP_474209      7 NLTKEKWIPVLdpdf----riqELSLVELFREwe--sLKEMRGd---NPPTTLALYRFLLAIMHRAYl----gPKDTDHW 73  Synechococcus s...
YP_145427      8 NLIDEPWIPVLkgg-----rvvEVGIGEALLR-----AHEFARietpSPLEEAVLHRLLLAVLHRALs----gPRCPEDV 73  Thermus thermop...

BAD59278      77 WSr-LWREWp--aDDIDRYLLAHRDRFDLFHPSt--PFFQVADLRs-AKDGvs-----sLDKLIADVPNGDKyft---tr 142 Nocardia farcin...
AAL21823      69 ED--IWFDGlh-aDVLHKALAPLEHAFQFGAETp--SFMQDFEPLsgEKVS--------IASLLPEIPGAQTtkfnkdhf 135 Salmonella ente...
CAE13041      66 HA--LYETSpd-kKVLQQNFNKVIHAFNVTGIGp--LFMQDFDPL--QTVKst-----tVAGLLIEAPGANGlrlntdhf 133 Photorhabdus lu...
Q46901        68 RHr-IMNPLt--eDEFQQLIAPWIDMFYLNHAEh--PFMQTKGVK--ANDVt------pMEKLLAGVSGATNcaf----v 130 Escherichia col...
AAR34761      68 KQr-IVAPLs--lDEFESGCAPYREWFRLDHPDf--PFMQVRNVS--AKDPt------pMDKLLAGLTGATNscf----v 130 Geobacter sulfu...
BAC75253      82 RLniLDAGQlp-pEGITAYAGRYRQRFFLYDRDggrPWMQDARLTg-QCDGgnt---agVNKLIVTRPAGNAha-----w 151 Streptomyces av...
tigr:CT1972   66 EQ--LDAETf--rRACRAYLEKWRDRFWLFGDK---PFLQMPAILdwMESQr-------AAGILSETENAKQi------- 124 Chlorobium tepi...
tigr:MCA0935  72 ED--FWREGi---RKLTGRDDDWAWTLIVDDVTq--PAFMQAPVPd-KKDFgafklkarTADALDILPTAKNhd-----v 138 Methylococcus c...
NP_289309     69 DD--IWEDGle-aEKLREALLSLEHPFQFGPDSp--SFMQDFEVL--MGDKv------qVASLLPEIPGAQTtkfnkdhf 135 Escherichia col...
NP_457332     66 AD--IWHESie-fEQWEKALNTISLALQFGEQKp--SFLQSFDPLd-SEYGs-------IAGLLVDAPGGNAlklnkdhf 132 Salmonella ente...
YP_474209     74 KE--IFQDNg---KRVIKYLQDRQDCFDLFHPTh--PFMQDPALPi-EKAVp-------VHSIHTMSTSEVFfh------ 132 Synechococcus s...
YP_145427     74 LD--WWRKGgfpqDPIRDYLNRFRDRFFLFHPEa--PFLQVADLP--EENPl------pWSKLLPELASGNNpt-----l 136 Thermus thermop...

BAD59278     143 aGRGLDHIDFGE----------------AARWLVHAHAFDPSGIk-------------tGAVGda---rVKGGKGYPIGV 190 Nocardia farcin...
AAL21823     136 vKRGVTERFCPHc---------------AALALFSLQLNAPAGG---------------KGYR------TGLRGGGPLTT 179 Salmonella ente...
CAE13041     134 iKRGIGDVMSLEm---------------ATLALFTLQINAPSGG---------------VGHR------VGLRGGGPLTT 177 Photorhabdus lu...
Q46901       131 nQPGQGEALCGGc---------------TAIALFNQANQAPGFG---------------GGFK------SGLRGGTPVTT 174 Escherichia col...
AAR34761     131 nEPGLGACLCGGc---------------AAIALFNQSSNAPSFG---------------GGFK------GSLRGGAPVTT 174 Geobacter sulfu...
BAC75253     152 fRHGSDARPDLPsa------------aeAVLSLLVWHYYGPSGRcsa---------revNGVK------TASATAGPLRT 204 Streptomyces av...
tigr:CT1972  125 -GPGFYPSLPSEndsilsqfqtlkaqtdAEKALFIVSVMNFAFGgtqinkniypseekvKGKGkpakpgPSLGRNGYLHT 203 Chlorobium tepi...
tigr:MCA0935 139 kASRSGATSPDG----------------WVYALVSLQTMSGFFGq--------------GNYGi-----ARMNGGFGSRP 183 Methylococcus c...
NP_289309    136 iKRGVTEHVCSHc---------------SALALFSLQLNAPSGG---------------KGYR------TGLRGGGPMTT 179 Escherichia col...
NP_457332    133 vKRGNVEQICPHc---------------AAIALFAIQTNSPAGG---------------AGYR------VGMRGGGPLTT 176 Salmonella ente...
YP_474209    133 eHEWSGYSISLPe---------------AARLLVRLQGVDITSL---------------RAFYvgqdsgNHSAVNTPTMN 182 Synechococcus s...
YP_145427    137 fDHTTEENLPKAty------------aqAARALLVHQAFAPGGLl--------------RRYG------VGSAKDAPVAR 184 Thermus thermop...

BAD59278     191 AWAGSlggvyleggdLRRTLLLNLVLad----------pDGDRYPd--------HDLPPWERdpdgpAVRDITGPSGPVD 252 Nocardia farcin...
AAL21823     180 LVELQeyqge-rqtpLWRKLWLNVMPq------------DTADLPlpdqcdatvFPWLAATRtseqaNAVTTPEQVNKLQ 246 Salmonella ente...
CAE13041     178 LVVPQqtd-----atLWQKLWLNVISrs----------eWHYSEPdlts--aqvFPWLAPTKvsvneGTEIHATDVHPLH 240 Photorhabdus lu...
Q46901       175 FVRGId---------LRSTVLLNVLTlprlqk--qfpneSHTENQ---------PTWIKPIKs----NESIPASSIGFVR 230 Escherichia col...
AAR34761     175 LVQGEh---------LRQTVWLNVLSeerlt----qiipWHHATRsq------qPTWVAPIKa----GETIPSQAIGVLR 231 Geobacter sulfu...
BAC75253     205 ALSYHpeg-----dtLFETLLAGLVPp------------EVTVRRs--------FDLCPWEReelpdPEAAPPLPCGPCS 259 Streptomyces av...
tigr:CT1972  204 FLFGSt---------IIDTLIMNLLSq-----------eEIDNLPfwe----kgIGTPPWENmp-vsRECDAALSLKKSY 258 Chlorobium tepi...
tigr:MCA0935 184 AVAVYha-------eRMGMRWHCDVTrlvgireellagpWGYRER---------GIVLVWEQp----WDLESSLSLNVLD 243 Methylococcus c...
NP_289309    180 LIELQeyqgn-qqapLWRKLWLNVMPq------------DEADLPlpkkfddlvFPWLGPTRtselaGAVVTDDQVNKLQ 246 Escherichia col...
NP_457332    177 LVVPQeed----kypLWKKLWLNVLPqee--------ppNVTQHPl-------iFPWLAPTKtsekaGNVVTPDNAHPLQ 237 Salmonella ente...
YP_474209    183 VANVLlkg-----rtLKETLMLNLMRy-----------sPEDEMPsvv----agEDVPTWETkvgytGQPKKEIPAGYIH 242 Synechococcus s...
YP_145427    185 PALFLptg-----qnLLETLLLNLVPy-----------tPEDDAP---------IWEVPPLRl----GDLEGARTKWPLT 235 Thermus thermop...

BAD59278     253 ----LFTWQSRRVRLVNs---------------------GAQVTGVVLCNgdale----sfnkqLLEPMTGwryseNQSK 303 Nocardia farcin...
AAL21823     247 ----AYWGMPRRIRLDFatlqsgccdicgaesdellgfmTVKNYGVNYDG--------------WRHPLTPy----RAPV 304 Salmonella ente...
CAE13041     241 ----MYWAMPRRIRLIVekgenickisg-kyseftvseyRAQNYGGNYTGn-------------WSHPLTPy----KWDP 298 Photorhabdus lu...
Q46901       231 ----GLFWQPAHIELCDpigig-------------kcscCGQESNLRYTGflkekft-ftvnglWPHPHSPc----LVTV 288 Escherichia col...
AAR34761     232 ----GLFWQPGHLELMPpqgeq-------------acicCGFVEKQVYAGfnkakfn-ytidglWPHPHGPr----ISSV 289 Geobacter sulfu...
BAC75253     260 ----RLTACSQHALLLVpdens------------pglvrDAYITWAYRTGr------------iPRDDNYLi----WQIS 307 Streptomyces av...
tigr:CT1972  259 m--gTLVSLSRFVLLHDd--------------------gIYYIDGLPYPSh-------------QEGWLEPs----MTID 299 Chlorobium tepi...
tigr:MCA0935 244 p---FYIEIARAVRLMG----------------------DGKNVRAFGAStkaarlaagdaggvLGDPWTPv----NVAD 294 Methylococcus c...
NP_289309    247 ----AYWGMPRRIRIDFntttvgncdicgeqsdallslmTTKNYGANYAM--------------WQHPLTPy----RVPL 304 Escherichia col...
NP_457332    238 ----AYWGMPRRIELDFthtvagicdlcgehheslllqmRSKNYGVQYDS--------------WLHPFSPy----RQAL 295 Salmonella ente...
YP_474209    243 ----YLTFPWRRLRLFSe---------------------AGRVQQLAITMg-------------NSLPNGVea-rqWECS 283 Synechococcus s...
YP_145427    236 grtrVYTWPARGVRLLDe--------------------gDGVRFMGYGPGv-------------EPLEATH-----RDPM 277 Thermus thermop...

BAD59278     304 KAGet----rHYPMVHDPEKSLWRGLRSLLGDVASSEpvagraiAPGVV------EWAATLldagal----ppdqpiRLH 369 Nocardia farcin...
AAL21823     305 KDQn-----aFFSVKPQPGGLIWRDWLGLSQNNQTEAny----eSPAQVvk---vFNARSLtdv-----------kaGIW 361 Salmonella ente...
CAE13041     299 KKLt-----pPLSIKGQPGGVTYKIWDALVFTSHESGq-----rCAPVVs----hFYSLCChfael------rrvmpRLW 358 Photorhabdus lu...
Q46901       289 KKGev----eEKFLAFTTSAPSWTQISRVVVDKIIQNen---gnRVAAV------VNQFRNiap-----------qsPLE 344 Escherichia col...
AAR34761     290 KKGer----eEKFVSFTTAAPAWTHLSRFVVQRQTTNske-egqEPAAV------VRQAQGll-------------nKLR 345 Geobacter sulfu...
BAC75253     308 QQGn------RYPRPADSRRALWRDLDALLLHEPPGT-------AQPQRpk--vfDYASEVs--------------eDLR 358 Streptomyces av...
tigr:CT1972  300 NQQn-----pPKAILVNPEKRPWRELVSILAVFDSNKnnk--fvCLFIK------YGLSRWpkrynkpgdkigvwsgGLQ 366 Chlorobium tepi...
tigr:MCA0935 295 KKKg------QSAMTVSASGLSPELIRNVLFEDGFRAa-----rMQCLLee---nEGQSCLfsat---------vlvRGQ 351 Methylococcus c...
NP_289309    305 KEGg-----eFYSVKPQPGGLIWRDWLGLIETGKSENn-----tELPALvv--klFNASSLkqa-----------kvGLW 361 Escherichia col...
NP_457332    296 KDPsa----pWLAFKGQPGGLSYKDWLGLMLNREDKFn-----kMQPAKv-----VRAAGQrn------------kmSLW 349 Salmonella ente...
YP_474209    284 VAYk-----eDKPVRLSLHRQLWRDADSFLLTASKQT-------RPRIV------DWLAELkseel------vnnlvVFE 339 Synechococcus s...
YP_145427    278 VAQrldakgnLLVLRLSEERSFWRDFSAMLPRQGGKVaa---tlEHAENlqgeleDEGLEGr--------------iTLR 340 Thermus thermop...

BAD59278     370 AVGMHYINN-----LSIVGDIVDDAIGFraamlasDPRLR------ICAVAAVQIAEEAVDALANLAADLAAAAGg---- 434 Nocardia farcin...
AAL21823     362 GFGADFDNMk----IRCWYEHHFPLLMTeg----lIPDLR------KAVQTAARLLSLLRSALKEAWFADAKGARgd--- 424 Salmonella ente...
CAE13041     359 VFGYDMDNMk----ARCWYSVTVPLFFVl-----fEQQEKilyqvkELQKLAINMIWLCRNQIKAAWFEKPVDVKgd--- 426 Photorhabdus lu...
Q46901       345 LIMGGYRNNq----ASILERRHDVLMFNq-----gWQQYG------NVINEIVTVGLGYKTALRKALYTFAEGFKnk--- 406 Escherichia col...
AAR34761     346 LAVGGYRNNq----ASILERRHELIFLNd-----gWSGHT------EVVHALVGQAVGYRDALNKALFVFSTGFKe---- 406 Geobacter sulfu...
BAC75253     359 VRALGFEQEgqakdTQFVDADTPPVMGFt------EQKAPat---aPAVGRMRQLGEMYGRRLERAVKRAWAEYMnd--- 426 Streptomyces av...
tigr:CT1972  367 VSFQTGEQYak-atNDFVESSVELDPDM-------WNNLWy-----DKFFGEISILEIMANKVKNGVINYYDSFEpkke- 432 Chlorobium tepi...
tigr:MCA0935 352 GTTDGFHHV-----AIPVPARAHRLFRRss----eRDRLAs-----ISKTALNDAKEIQNRVLKPSVIALLEAGPdki-- 415 Methylococcus c...
NP_289309    362 GFGYDFDNMk----ARCWYEHHFPLLLNkke--gqIPKLR------LAAQTASRILSLLRSALKEAWFSDPKGARgd--- 426 Escherichia col...
NP_457332    350 CFAWDMNKAk----VRCWYQHRIPLISVsh----eEQFLAal---nIVLVLASESLSLLRNALKSAKFDCPKEAKmd--- 415 Salmonella ente...
YP_474209    340 VLGMSADQAk----PLGWSSARFSVPMQfv----tDSELAqs--lkSAIGIAENHQQIFRSSKGSPYFSLAEVLKn---- 405 Synechococcus s...
YP_145427    341 VLGQVSDQAk----VLDIRREVYPLPSGl-----lTPKAE------ENLEKALKMAEELGQGLKHLAQEVAKAVVgerdr 405 Thermus thermop...

BAD59278     435 ---------EPTGARMRAREEGFfal------eapYRRWLAGLvpqst-----------gyarqAAEWEQTAFVIVRRLG 488 Nocardia farcin...
AAL21823     425 --------fSFIDIDFWNLTQGRfl---------nLIHDLENGhkp---------------derLNKWQRELWLFTRHYF 472 Salmonella ente...
CAE13041     427 --------tSFIDLTFWQQSESLff--------svVHQLIDNAnsdapf----------ltpeqAKHWLNTLRYLCRDLF 480 Photorhabdus lu...
Q46901       407 -------dfKGAGVSVHETAERHf-----------YRQSELLIpdvlanvn------fsqadevIADLRDKLHQLCEMLF 462 Escherichia col...
AAR34761     407 --------iKGAGVKVHELAKEQf-----------YRRSEDTVldtlarid------feqaalaLLAMGDGLHGIVVGLF 461 Geobacter sulfu...
BAC75253     427 --------pKANGDTWAAEAAAR------------YWPGAEAEfw------------------dRFRHLDNTGHTLGAGF 468 Streptomyces av...
tigr:CT1972  433 -----kkpkERASTIMGKKAVEL------------FWQLCERRfpelvda--------cgepdkLPAIHEAINLLALQSY 487 Chlorobium tepi...
tigr:MCA0935 416 ------nfdRREVNLWLNEATQRfsaa----wsedYFPWLWRQaeqdd------------adaaRLEWLRALRDKAHKVL 473 Methylococcus c...
NP_289309    427 --------fSFVDIDFWNKTQHRfl--------rlVRQIEEGQdad----------------elLGKWQKEIWLFARQDF 474 Escherichia col...
NP_457332    416 --------fSMVDIAFWQETEPAfrtlqealavdpLRQDTQTRh-------------------aVSQWEAELAHYLFHVF 468 Salmonella ente...
YP_474209    406 --------gETEKLSKALDGESR------------YWAILDHAfsmllhdlpqdnqpgadgiiyYGLTTLPAWTKTVQDA 465 Synechococcus s...
YP_145427    406 ghgrspyleELTKLANSLPLERL------------YWHALDGA---------------------FPRFFARVEEEASLDL 452 Thermus thermop...

BAD59278     489 TEYIAAag-----dVAWVgrpvrek-----wldssiAERWFYKKLRAVLP 528 Nocardia farcinica IFM 10152
AAL21823     473 DDHVFTnpy--essDLERim--------------taRKKYFTTSAEKQSA 506 Salmonella enterica subsp. enterica serovar T...
CAE13041     481 DEYVALselgnersIAKRm----------------kARQQLIIGLYGQKA 514 Photorhabdus luminescens subsp. laumondii TTO1
Q46901       463 NQSVAP--------YAHHpklis---------tlalARATLYKHLRELKP 495 Escherichia coli K-12
AAR34761     462 NESVAPyrn---dpELIRtt--------------avARKTLYKHLNALKP 494 Geobacter sulfurreducens PCA
BAC75253     469 DPAAARtaflrlatDAYDtvtasvtrtqrgakavahARIDLYGGVRKKAT 518 Streptomyces avermitilis MA-4680
tigr:CT1972  488 DAYCPKeta--rqiDAWAe-----------------CQKDLKKFIRELME 518 Chlorobium tepidum TLS
tigr:MCA0935 474 EEAIARyps--regRRYRar--------------vkAEGLFHGSLFKTFP 507 Methylococcus capsulatus str. Bath
NP_289309    475 DERVFTnpy--epvDLERvm--------------taRKKYFTTSAEKQSA 508 Escherichia coli O157:H7 EDL933
NP_457332    469 DRDALTnpdc-pddILQRql---------------tARQDLASSYRKHKA 502 Salmonella enterica subsp. enterica serovar T...
YP_474209    466 ARRAFTes-----iESIRnyqa-----------raaALRTLERKLAELRA 499 Synechococcus sp. JA-3-3Ab
YP_145427    453 WREALRga----alEAWKa-----------------TRRFLGTGARHLKA 481 Thermus thermophilus HB8
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap