Conserved Protein Domain Family
Cas8a2_I-A
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cd09666: Cas8a2_I-A 
CRISPR/Cas system-associated protein Csa8a2
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-A subtype; also known as Csa4 family
Links
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Statistics
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PSSM-Id: 187797
Aligned: 5 rows
Threshold Bit Score: 430
Created: 5-Feb-2010
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q57830     24 VMLFETpGYNEILDLYIAYGVVECLVREGVENLRFFPIGNKYCIVVEEPTnvn------ikN--------RIEKGMLNAL 89  Methanocaldococcus...
NP_578366   3 FNEFKTpQIDPIFDLYVAYGYVESLIRGGAKEATLIPHGASYLIQTDVSN-----------E--------EFRHGLVDAL 63  Pyrococcus furiosu...
NP_558443   2 LKEIYTpGHDVFADTLIMHGVVRHLAASGIVEGYVERLGERYKISFEGEPral-----adiE--------SVELLLFEIE 68  Pyrobaculum aeroph...
NP_578367   5 VPMFSG-YYSRVLNTHIMYGIVESALRAGVTNLHVVPTGEGYEIHSRYLDcrl-----knqEdlegegckLLLEGLRDAL 78  Pyrococcus furiosu...
NP_147806   2 VCILYTpGHNLYTDTLILYGIARLLAWSGKVSGEVERVGERYVVKVDADNchpvsqlpesiR--------LALRLLQEEQ 73  Aeropyrum pernix K1

Q57830     90 EDMLSLHKAIGk------yISTKEDIKIISDVDFSAGANINN-VYWDGIPKTLEKIKENIKKg-Kl------STKSKNTV 155 Methanocaldococcus...
NP_578366  64 SEMLSLHIALAr-------HSPREGGKLVSDADFSAGANINN-VYWDSVPRNLEKVMKDLEKk-R-------SVKGTATI 127 Pyrococcus furiosu...
NP_558443  69 RYVVDGEEPVGr------lRKIFDANINISATRSWLAQLSEAlVNAELSVFTLDHKAKFREG--Rt------ASRRLSTV 134 Pyrobaculum aeroph...
NP_578367  79 EEIIMTHYAMGf-------RSKKFNNVILSNTVISNGAFIDPpQNVQRYYRELEAILNNLDIk-SlkstkslIDKKVLRA 150 Pyrococcus furiosu...
NP_147806  74 QQVFLGDEGTFysdlyrlaRGSKVGESILNNLRIRVAAKILS-NDANILEKYVSPGHKKLQGefRg------RKKGLVTL 146 Aeropyrum pernix K1

Q57830    156 PLTLMPAAGKYMPKIYGVK--GGNpiKIDDSNYALAWIGFHYYApyINISDNRATYIHIYAIKPLEELGLIEILALKDLK 233 Methanocaldococcus...
NP_578366 128 PITLMPSAGKYMLKHFGVQ--GGNpiKVDLLNYALAWVGFHYYTpyIKYAKGDTTWIHIYQIAPVEEVDMISILSLKDLK 205 Pyrococcus furiosu...
NP_558443 135 YLTLSPIYGKYFIENRVAK--ENKafGVCHTCFAYLNIGFLYGAttIVIITRDGRRVVQLTPAPRGRISIADLALLQRLT 212 Pyrobaculum aeroph...
NP_578367 151 PQQLDPTLNQWLSFYKQEE--GIS--RITNLEYALAWVGFYYYSsvHKFKRGSSQIVEIIQYPPNEEVEMWELLLIKDLA 226 Pyrococcus furiosu...
NP_147806 147 VLPLGPLYGKFYTWSLKPRrlTEKpyVVCPYCYFLSVLGFHYGS--YTYQKDGESKVVTLSPHHASLEDVLALSQSFEAA 224 Aeropyrum pernix K1

Q57830    234 KKINNyqlgkykffvNKKLALLYHLTHTESISALEIVT-KKNFSVVSYTLEnVDNNQAIRSFGEYDlSKLMDFLWYLKAt 312 Methanocaldococcus...
NP_578366 206 MHLPHyyesnldfliNRRLALLYHLLHSESLGALELFT-EKEFVIHSYTLErSGNNQAIRSFEEEEiGKLMDFLWKLKRr 284 Pyrococcus furiosu...
NP_558443 213 EGYLVr---------SQEMPTLAYPLYWLSTGETLYAT-EESLDILVWVTEkRGNFQRVTDAMALDlSRIMEFIAEVKN- 281 Pyrobaculum aeroph...
NP_578367 227 TKIVQgndf--hwkiSSEYGLLKTLLLTELPPSTEEVPgLSKFTVVIYGQE-SQQGKGWRIFRTLElPVVWDFIGYLKAr 303 Pyrococcus furiosu...
NP_147806 225 SIWMPail-----ryRNSLTGPGLSLYVLSLGETLLSS-SSHFEVLYGEFSvDNNTFRVVDVGRLP-GVLLTSIAIIKY- 296 Aeropyrum pernix K1

Q57830    313 DFYNTIQFVDNILRGD-----------L--EVSLTFIDGILYDDLDavYSAIR--------KLKS-VRISPLIIQSILEW 370 Methanocaldococcus...
NP_578366 285 DFYHAIKFIDDLLKKA-----------T--EGALALIDAIMNERLEgfYTALKl------gKKAG-VVSSREIVAALEDI 344 Pyrococcus furiosu...
NP_558443 282 KTRGWPKFVECLALEG-----------P--EILAQLTEVVLFGGDE--YTVVRa------lSTSGkCAEDWRQVDILAEI 340 Pyrobaculum aeroph...
NP_578367 304 AFYETMKFVKILNKLErtikesqedilR--EISHQLYSALTNRDEMgfYSAFRv------lKRAG-YPLDPELVNAIAQY 374 Pyrococcus furiosu...
NP_147806 297 HMASWPRLIDFIARRD-----------PglLHRIALTLSFEVGNEYalYGILReilsllndDKSQeARYLAKQLDRLAEG 365 Aeropyrum pernix K1

Q57830    371 FGNF 374 Methanocaldococcus jannaschii
NP_578366 345 ICER 348 Pyrococcus furiosus DSM 3638
NP_558443 341 LFTW 344 Pyrobaculum aerophilum str. IM2
NP_578367 375 LSER 378 Pyrococcus furiosus DSM 3638
NP_147806 366 LAMV 369 Aeropyrum pernix K1
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