Conserved Protein Domain Family
Cas4_I-A
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cd09659: Cas4_I-A 
CRISPR/Cas system-associated protein Cas4
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster
Links
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Statistics
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PSSM-Id: 187790
Aligned: 7 rows
Threshold Bit Score: 322.45
Created: 5-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_558367   3 REFRMVRGLRVEVGEELRGWRWGepPVQPPPLgVRLSVSDIVgGGCESRRDLYLKrVLGVRae-pNGGMk-fGAYIHEVF 80  Pyrobaculum aeroph...
NP_378643   7 LKRLHRIREMDPVPDELRGWHYYspPVKPKAY-LGLTMGEIAyDYCPTKRDVYVRrVLNQKgs-eRAQLv-fGQAIHKVF 83  Sulfolobus tokodai...
NP_342892   9 LRRLHSYRASDPIEEELRGWNYYmpPIKPRRY-LGLSISDVAyKYCETKRDVYLRkVLKIQge-qRTPLl-lGQAIHEIV 85  Sulfolobus solfata...
NP_558440  11 LRRAKITWGPVEISPEYRGWNYDkpPVKPPAY-LGLALSDFAyGYCPTGRNIYLKyVLGERgaavKALVe--GQALHQAL 87  Pyrobaculum aeroph...
NP_375869  10 LLSKRMKGFPRAISEELRGWHWNepPLYPSSN-TLLSVSDLTnGLCDSGRYVYLK-HKGIVpk-vEAKI---GNTIHTTY 83  Sulfolobus tokodai...
NP_147816   6 LWDLVRSSAGDGVYAELRGWKWN--VVGPRYA-ARPTLSDVT-GVCPVGRDTYLRrVLNTRv---NGGLlrlGALVHEAF 78  Aeropyrum pernix K1
NP_070704  14 TLELRPRIRQNPVPEELRGWNWHspPLKPYYN-VKLPMYLICsRYCPTSRDVYLTmVEKVRge-eSFPVs-lGKAIHEAV 90  Archaeoglobus fulg...

NP_558367  81 KRSLAELRslIEGGAVKG-WELVQSFNAEaiareaaiaaeaeadprGVELArylaiqvAARVDEIa-SRSSa-DSLSIaa 157 Pyrobaculum aeroph...
NP_378643  84 SKALNDVRisYVLGKDPY-QIVKESYLESefcpq-------eiseyCRKVYgnlilfwSSWLAEA--KAFYggDSVGF-- 151 Sulfolobus tokodai...
NP_342892  86 RNVSNEVVklLSSGYKPW-SVLETLFRNNkivr----------slcPPQFIkyceevyKAYALDLl-SDFS--DSTSF-- 149 Sulfolobus solfata...
NP_558440  88 FKALEDYKk-YAYSGHPM-SPSFEGVPEDvrpk----------aeaLYKYVatrllgeHSYVSAArlARSR--DSAVFy- 152 Pyrobaculum aeroph...
NP_375869  84 ATAIETIKr-LIYEHEDLdSVKLRTLMTDefynlk-----vevievAKILWdhivsiySAELEKArsKPFLrkDSLASl- 156 Sulfolobus tokodai...
NP_147816  79 LLPFKAHR--VGDAYRMF-NYLLRRVRAR-----------------GNEIRv-----mNAVFEKA--VEFS--AAARVd- 128 Aeropyrum pernix K1
NP_070704  91 AKAIREAKs-KNFSAEPP-NYDNEMINVAv----------------KAVWEytmslcqSSYLKVRseQPYA--TEEGVll 150 Archaeoglobus fulg...

NP_558367 158 raVPVLAEYVIDGRPLGLTl-VRADALYyn--vVVEIKVGSYSERHAl---ALAGYALAIEADEEVPVDAGLLISVAFNG 231 Pyrobaculum aeroph...
NP_378643 152 --LPWATEVRVDGSAIGLSdrLTVDALGef--tVVEVKSGKREEFHKl---ALAGYALAIESVLELPVDYGLLVYINGFP 224 Sulfolobus tokodai...
NP_342892 150 --IPVISEFKVDGSPLGLSsrLSVDAIMql-slVVEMKVGSVQEFHRl---ALAGYGMALESALELPIDFGALIYVNGIN 223 Sulfolobus solfata...
NP_558440 153 -tAPIATQVAVDGSPLGMSy-VVADGVAlg--aVIEFKFGPAQNVDA----ALAGYAMAIEADWGVPIDYGIHVQITVNS 224 Pyrobaculum aeroph...
NP_375869 157 -vIPFHVEYPVDGSLVGLQsaLRVDAFIpilplIAEMKTGSYKRDHEl---ALAGYALAFESQYEIPVDFGYLCYVNVIE 232 Sulfolobus tokodai...
NP_147816 129 -gIPVAVEPNVPGGPVGLSdyVRPDLLVgi-mpVDLVLAGHGDRWVArkelAIAGYALAVEAWTGNPVDYGVVVGLRVND 206 Aeropyrum pernix K1
NP_070704 151 tsMPFLVEHRMDGSLLGCSglISVDCYDylrnvVFDLKVGEFNEEMRl---YTTGYALVLESIHEIPVDVGCIISITFNG 227 Archaeoglobus fulg...

NP_558367 232 G--VKLRAYPVAIGEGLRREFLEERNRLMELVASGsDPGLSPKCDDKCPLWRHCH 284 Pyrobaculum aerophilum str. IM2
NP_378643 225 Nd-VEIKFESYYISPDMRREILDKRDEIIEMVLNGrDPGKPVKCPETCPFYEVCW 278 Sulfolobus tokodaii str. 7
NP_342892 224 TssPEFKVEVFYVSPDMRKEFLDARDEVIDMISQEkDPGMPVSCSPSCPFLNYCN 278 Sulfolobus solfataricus P2
NP_558440 225 T--VEYKATAYPLGDSARTKFLELRDEAIDIVIAGrDPGVAPDCPKTCPFYHICH 277 Pyrobaculum aerophilum str. IM2
NP_375869 233 Gk-IHNNCRLIVISDTLRQEFVEVRDRALRAIDDDvDPGLAKKCSADCPFLPHCK 286 Sulfolobus tokodaii str. 7
NP_147816 207 G--LKIVWRLVRVDDHLRTRFLERRDAVARIIEYRsDPGLPEACPPGCVFREVCG 259 Aeropyrum pernix K1
NP_070704 228 Er-MRVSKDLHYIDANLRSWWIEERDRKAEIVFNEaDPGVAKSCSSNCLFNAFCL 281 Archaeoglobus fulgidus DSM 4304
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