Conserved Protein Domain Family
Cas8c_I-C
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cd09642: Cas8c_I-C 
CRISPR/Cas system-associated protein Cas8c
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Large proteins, some contain Zn-finger domain; signature gene for I-C subtype; also known as Csd1 family
Links
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Statistics
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PSSM-Id: 187773
Aligned: 11 rows
Threshold Bit Score: 580.508
Created: 5-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
tigr:CT1133   20 MILQALYDYYQRKAAdpesg----------iapegFEWKEIPFIIVIDreGNFVSLEdtreg----------------dg 73  Chlorobium tepi...
tigr:MCA0655   1 MILQALYEYYGRKPElpa---------------lgFEEKEIPFLIVVDeqGRFVQLEdtreg----------------eg 49  Methylococcus c...
AAQ58901       1 MILTELLDYYQRQAVldtv------------prfgFSSEKISYALLLNeaGQLADLPrdirva---------------kg 53  Chromobacterium...
AAS94334       1 MILQALHGYYQRMSAdpdag----------mppygTSMENISFALVLDakGTLRGIEdlreq----------------eg 54  Desulfovibrio v...
AAN47886       1 MILQELVKYYERKLEerei------------aregFETKEIPYLIEIDeeGNFIRFIstwqd-----------------e 51  Leptospira inte...
NP_241204      2 SWLLHLYETYEANLDqvgktvkkgedreytllpisHTTQNAHIEVTLDedGDFLRAKa---------------------- 59  Bacillus halodu...
YP_867412      2 SWMQMLHTTYECCKDqlg--------------piyHTTQQAHLEVVLDhsGTFLRAHvps-------------------- 47  Magnetococcus s...
YP_635131      1 MMLTALNDFARERGLtdd---------------plYEVKPVDFFIRISakGKFIKLEslar------------------- 46  Myxococcus xant...
YP_002753896   1 MFVQALAGYADTHLRkqld-------------dvaFEERPVQYFLQIGkdGSFLGVIprftevpvaspkqkkgsadkppk 67  Acidobacterium ...
AAS82464      25 AMLRELKEAFHRFRKegvl------------lplaYKRKSVAWFIRLE--GGKARLEgpy-------------------- 70  Thermus thermop...
AAK34352      14 AELADLVDHQKRNNEpvllpi---------yhtslKSNGKNIISVKLDkdGQFHKAEfmadkqmii--------fpvtad 76  Streptococcus p...

tigr:CT1133   74 kkkKAKPYLLPKSVg---RTGsn--sYKTSFLLWDHYGYVLGhsrsesdkdqamaEKQMPS-------FIEkLRSLp-eN 140 Chlorobium tepi...
tigr:MCA0655  50 kkkVPKRFFVPQAVk---RTA-----GIAANVLWDNSSYVLGmdakg---kperlKEQTRA-------FEQaIRDL---G 108 Methylococcus c...
AAQ58901      54 kryEGRVLNVPQPEk---RTA-----GIRANFLWDKTGYVLGvgaks----ggrvADEHAA-------FKA-LHAKwlaD 113 Chromobacterium...
AAS94334      55 kklRPRKMLVPIAE----KKGn----GIKPNFLWENTSYILGvda-------kgkQERTDKch---aaFIAhIKAYc--D 114 Desulfovibrio v...
AAN47886      52 kkkRASSYTIPKAVi---RSR-----GIEANLLWDNFEYIFGl-----------eKKEKQKd------FIRkIQDL---E 103 Leptospira inte...
NP_241204     60 --lTKESTLIPCTEeaasRSGs----KVAPYPLHDKLSYVAGdfvky----ggkiKNQDDApf---dtYIKnLGEWa--N 124 Bacillus halodu...
YP_867412     48 -skTDSTTLIPCSEksagRTS-----GLMNHPLADKLQYVAGdylsf---agalsEKEQTKmmeshrlYKEaLATWa--D 116 Magnetococcus s...
YP_635131     47 edgRGNAMPIPRLPq---RSV-----NIAAGFFADNSKYVLAyekdapkakaggvEKRLARle----aFLKpVREVv-aE 113 Myxococcus xant...
YP_002753896  68 trlQPELLSVPRSPa--nRNS-----GLHPLLGSDDIKYVLGpgpwtkaselenhRDRHEA-------FVElLRRVa-kE 132 Acidobacterium ...
AAS82464      71 -gkREGVEPIPAPDr--qRSGkaseaNLKPYLLVDDARYVLGlfe--------egREDEAAllh--kgFKE-LTEKawrE 136 Thermus thermop...
AAK34352      77 svaRSGSHPAPHPLv--dKFAyy--sAEMGQIQYDSFHKQLNnwi-------dycEEGDVKk------FLTfVQQF---I 136 Streptococcus p...

tigr:CT1133  141 VKGDd--GVLAVIRFYEKg--EYKKVKEsdnwge----------------------------ctkiiGCNMSFRLDGEVd 188 Chlorobium tepi...
tigr:MCA0655 109 LEDDa--GVSAVLAFLDS---KEEKAKAleaassw--------------------------peilekGANLAFRLQSRSe 157 Methylococcus c...
AAQ58901     114 SEDE---GLRALRRFLQDw--RPEQFDAfppel-----------------------------qeslrDANVVFRLDGRRe 159 Chromobacterium...
AAS94334     115 TADQ---DLAAVLQFLEH---GEKDLSAfpvs-------------------------------eeviGSNIVFRIEGEPg 157 Desulfovibrio v...
AAN47886     104 SKSEessSLTSILNFFSKl--KMPELKKdplwa-----------------------------eieedKHYLTFKLQGQNe 152 Leptospira inte...
NP_241204    125 SPYAt-eKVKCIYTYLKKg-rLIEDLVDagvlkldenqqliekwekryeellgekpaifssgatdqaSAFVRFNVFHPEs 202 Bacillus halodu...
YP_867412    117 SPQSh-pTVKAIYAYVAQg-rLVGDLVNagilpcvegsippkwqg-----pkeetpaiykavtgmplDAFVRWRVEPAPg 189 Magnetococcus s...
YP_635131    114 TKDA---EARAVESFLDS---EAERSKAladrga----------------------------eewtgSEMLAFVVGEATt 159 Myxococcus xant...
YP_002753896 133 TRDR---ALEICAQFYDQp-eQVERAREalak--------------------------------vtpGSNVALFVFGQPv 176 Acidobacterium ...
AAS82464     137 TQSP---HVKVVLDLLSSp--ELGDLREefrqk------------------------------ggkpRDLLAFKVHGVLp 181 Thermus thermop...
AAK34352     137 LKPE---FLTLILDSLIGpdyQHNQLKVtfcdatgk------------------------eklidlsACFLEFSIDQFQg 189 Streptococcus p...

tigr:CT1133  189 l-----vPCRDAVKRYIETqiges-----addavGLCLVTGKK-AAI-ARIHSDTPin-------kDSKKFVSFQk-NSG 248 Chlorobium tepi...
tigr:MCA0655 158 l-----vCQHEMVRTALTRrltea------nadpTVCLVSGEE-DAP-ERLHPPIKgvwg---gqpTGANIVSFN--LDA 219 Methylococcus c...
AAQ58901     160 y-----vHESPTAQQLRARmlaeg------ggdtGMCLVSGET-APL-ARLHPAIKgvng---aqsSGASIVSFN--LES 221 Chromobacterium...
AAS94334     158 f-----vHERPAARQAWANclnrr-----eqglcGQCLITGERqKPI-AQLHPSIKggrdgvrgaqAVASIVSFN--NTA 224 Desulfovibrio v...
AAN47886     153 i----icSDKTIVQTISQNasdd-------evekGICLVSGKT-NPI-ERLHSKISltg----antSGANLVSFN--LDA 213 Leptospira inte...
NP_241204    203 id--dvwKDKEMFDSFISFyndk-------lgeeDICFVTGNR-LPS-TERHANKIrh------aaDKAKLISANd-NSG 264 Bacillus halodu...
YP_867412    190 vceiepwNDPQLIQAWIDHylalle----esaprGTCMVTGQT-DVLlAQSHPAKLrh------aaDKAKLISANd-SSG 257 Magnetococcus s...
YP_635131    160 p-----vHQNPAIRACWERragaqr----algrrALCLVTGRE-GVV-AVTHPKLKnvpe---aqpSGASLVSFN--APA 223 Myxococcus xant...
YP_002753896 177 -------TERDEVRAWWRQhyeasta-ergagqtAECLISGVV-GPI-PSTHAKIKgtsal-ggqpAGVSLMSFD--KPA 243 Acidobacterium ...
AAS82464     182 -------TELEEVQAFWARhlaee-----iqggkGYCALCGTL-GPV-LRIFPREVvv------lgQKCQLVSFN--QKA 239 Thermus thermop...
AAK34352     190 -------FKNESVSTFKALhqsyisfveanrenlGICNISGRE-EQL-TDKHRGLM----------GNAKIISVSnkREA 250 Streptococcus p...

tigr:CT1133  249 YDSYGKEQAFN--APISESAVFAYTTALNMLLGkn-------sKNKVQVGD-ATTVFWSEKQdvfeed------------ 306 Chlorobium tepi...
tigr:MCA0655 220 FNSWGKSQGDN--APVGKRAAFAYTTALNHLLAkd-------sKQRLQVGD-ASTVFWAAQAnpledll----------- 278 Methylococcus c...
AAQ58901     222 FASYGKSQGAN--APISEFAAFAYTAALNHLLRree-----dnRQRLQIGD-ATVVFWARAAsaegavaae--------- 284 Chromobacterium...
AAS94334     225 FESYGKEQSIN--APVSQEAAFSYVTALNYLLNps-------nRQKVTIAD-ATVVFWAERSspaedifagmfdp--pst 292 Desulfovibrio v...
AAN47886     214 FESYGKKQGSN--APTSKYANFAYGTSISSLTSkd-------sRQKILIGN-TTMMFWSETKnelede------------ 271 Leptospira inte...
NP_241204    265 FTFRGRFKTSReaVGISYEVSQKAHNALKWLIH----------RQSKSIDD-RVFLVWSNDNsl---------------- 317 Bacillus halodu...
YP_867412    258 YTYRGRFLSADevCGVGLETTQQVHNTLRWLIE----------KQGYRQGD-LRIVAWAVDGrttpgilistq-----el 321 Magnetococcus s...
YP_635131    224 FSSHGLEQGEN--APISQEASLGYVLALNDMLRrteq---rrfRQGIQLADgSVMVFWTRASpseesf------------ 286 Myxococcus xant...
YP_002753896 244 FRSYGWEQNAN--SPVSSDRAMAYVLALNDLLKp--------gSQNRKDFDgVAFLFWLKRDvdidyn------------ 301 Acidobacterium ...
AAS82464     240 FESFGKEQAAN--APLCFTCASQVVDTLDYLIRserhsrplyrEEEGGLRN-QLAVFWLSEKvevpletpvdletilgav 316 Thermus thermop...
AAK34352     251 YKGRFREREDV--FSVGYETSEKIHLMLKYLLEn--------kNTSTWLGSsQYLINWFSDDltndsrldiv-------s 313 Streptococcus p...

tigr:CT1133  307 ---fpaffgYSKDDPDADVRavkaly------------------egiksgHAQMDS---KTRFYVLGL-APNSARISVRF 361 Chlorobium tepi...
tigr:MCA0655 279 ---adlfsePPKDDPDRNTRavesly------------------kaphtgASVFDDd--GTQFYVLGL-APNAARIAVRY 334 Methylococcus c...
AAQ58901     285 -aafadwldPPADDASEAQRvlaalqdi--------------adgrpaaeLGLRLEp--DTRLFVLGL-APNASRLSIRF 346 Chromobacterium...
AAS94334     293 takpessngTPPEDSEEGSQpdtarddphaaarmhdllvairsgkratdiMPDMDE---SVRFHVLGL-SPNAARLSVRF 368 Desulfovibrio v...
AAN47886     272 ---flsllkPSDEDQKKDSKrkqearsnqtik-------ehfvspftgklQHLLND---GTKFFILGL-APNAARISVRF 337 Leptospira inte...
NP_241204    318 -------vpNPDEDAVDIMKhanrelerdpdt------gqifagevkkaiGGYRSDlnyQPEVHILVLdSATTGRMAVLY 384 Bacillus halodu...
YP_867412    322 lgdnvpaetEEEDELLPTSSmghsvdqsfg----------lrlgkkisgyYSQLGD---LTDIVVMGIdSATPGRMSIIY 388 Magnetococcus s...
YP_635131    287 ---llslldPTEDDLKRFVEspr------------------------kgvEPGELD---DRAFYAVTL-AGNAGRVAVRD 335 Myxococcus xant...
YP_002753896 302 ----slleePPSDVLLDKARaiig----------------------lkngAWMRQEe--RNELYMAAV-SATGSRLVLRS 352 Acidobacterium ...
AAS82464     317 lsgalvhspTPPADLTQLQEllatp--------------------wtgkaWPLNLD---ETRFHLAVL-SANKGRLVVRE 372 Thermus thermop...
AAK34352     314 pifddgleeDDDDDTPPVITlatednkr--------------igksfikgQKLFAN---DATYYVAILnKTSNGRIALKY 376 Streptococcus p...

tigr:CT1133  362 WHTGTIAEFAGNIRQHFDDLEIIRSPkdsgh--------fsmfwLLSAMAHEG-----KVDN-----VPPNLSGQIFQSV 423 Chlorobium tepi...
tigr:MCA0655 335 WHVATVRELARHIKQHFRDLEIIHAPsekpy--------lslfrLLVCTATQG-----KSEN-----IPPNLAGEFMKSI 396 Methylococcus c...
AAQ58901     347 WECGRLESFATRLAAHYRDLELAPLPwkrpp---------gvwrLLYAVAAQG-----KAEN-----VPPQLAGELARSI 407 Chromobacterium...
AAS94334     369 WEVDTVGHMLDKVGRHYRELEIIPQFnneqef-------pslstLLRQTAVLN-----KTEN-----ISPVLAGGLFRAM 431 Desulfovibrio v...
AAN47886     338 WYPSTVGEISKNINQHFTDLKLEIYNiesgf--------islnrILSSTAIQG-----KMEN-----VSPLLSGKLVTSI 399 Leptospira inte...
NP_241204    385 YRSLNKELYLNRLEAWHDSCAWEHRYrrdekefisfygapatkdIAFAAYGPR-----ASEK-----VIKDLMERMLPCI 454 Bacillus halodu...
YP_867412    389 YRELQQTEFLQRLEKWHSQMAWPQNFgkdsqft----gapaprdIAEAAYGRR-----LDDK-----LKSTTLQRILPCI 454 Magnetococcus s...
YP_635131    336 WFESRVGEVKQNIRRYFDDLRMGDAPa-----------------GPIPVYRLLk----AVEApsgrgLTPDIAARMLGAA 394 Myxococcus xant...
YP_002753896 353 WSSMPLEDALESLLGFWEQLKMQPLEkdk-------------ppRAEPFWKLLh----ALDReg--rPPASRTVALRRRA 413 Acidobacterium ...
AAS82464     373 WLAVSLSRLKETLGRFLEGTRLVRPWg-----------------EAPQPVPVGa----LVQAlg--dGNPGLVRGLLRTA 429 Thermus thermop...
AAK34352     377 FRQLQASQLLTNLNKWQETYSWESRSkfgksrl----rtptfhdILNVSYGVDrdrflELDNd---nFKSDQIQKLVASL 449 Streptococcus p...

tigr:CT1133  424 ITG--GLYPATMLQQAIRRIRATQ------------EVTRIQASILKACLNRfsriy-ntkaKEITVALDPT--NNNPGY 486 Chlorobium tepi...
tigr:MCA0655 397 LAG--IPYPHSLLQAAIRRIRADR------------EITYPRAALVKACLNRqtrysnpdnvKELTVALDDT--QTNIGY 460 Methylococcus c...
AAQ58901     408 LGG--GRYPRSLLVNAIMRMRADG------------ELSGTRVALCKAVLGRdqrlgvaginLELPVSLDIA--NRDPGY 471 Chromobacterium...
AAS94334     432 LTG--GPYPQSLLPAVLGRIRAEHarpedksryrleVVTYYRAALIKAYLIRnr-------kLEVPVSLDPA--RTDRPY 500 Desulfovibrio v...
AAN47886     400 ISG--SEYPRTLLSSILIRLKAEK------------EISFVRVSVLKAILNRkgrfekfknyKELTTSMDEE--NINVAY 463 Leptospira inte...
NP_241204    455 VDG--RRVPKDIVRSAFQRASNPVsm--------erWEWEKTLSITCALIRKmhi----eqkEEWGVPLDKS--STDRSY 518 Bacillus halodu...
YP_867412    455 IDE--QPFPEDLIHAVVHRTSNRVafdrs--ktgfqWEWEKCLGIACALVRGsnlr--ahikKEYAMALEPD--YTSRDY 526 Magnetococcus s...
YP_635131    395 LRG--QPFPRQLLVAALDRLRLPPadgg-----verEQLRLRVALIKAYLLRdrnr--gstpLEVTVSLDKD--NPSQPY 463 Myxococcus xant...
YP_002753896 414 LEGrcSPLGYRIVSDVLARMRADKe----------kRRDIAALGLLRLCLNDlhat--tgkgEPMPAALDETepPQHPAY 481 Acidobacterium ...
AAS82464     430 YLGtpPPHALSLAIHLLRNPKTLTpe---------eREGWGRLHALVAALKLwlfy--gkeeAKRMAELDKE--RKNPAY 496 Thermus thermop...
AAK34352     450 IDG--KPMPQSIVKKLGNNVKERHry---------rKHWYQVEQVCLAILHKqn-------gEEFSPMLDHT--NQNRSY 509 Streptococcus p...

tigr:CT1133  487 RLGRLFAVLEKIQEEASpg-----lNATIRDRFYGAASSTPVTVFPQLLKL-KNHHLSKLDNagr------rvNFERMLA 554 Chlorobium tepi...
tigr:MCA0655 461 RLGRLFAVLEKIQEEANpg-----iNATIRDRYYGAASSTPVAVFQTLMRL-KNHHLAKLENrgr------avNLERLIG 528 Methylococcus c...
AAQ58901     472 LLGRLFAELESIQRGALge----kiNATIRDRYYGAASATPANVFPLLLRN-AQHHLSRLRKdkpg----lwkTLERDLA 542 Chromobacterium...
AAS94334     501 LLGRLFAVLEKAQEDAVpg-----aNATIKDRYLASASANPGQVFHMLLKN-ASNHTAKLRKdperk--gsaiHYEIMMQ 572 Desulfovibrio v...
AAN47886     464 RLGRLFAVMERLQERANpg-----iNATIRDRYFSSASSRPATVFPVLFNL-SMHHASKSGSv----------WFEKLKG 527 Leptospira inte...
NP_241204    519 LFGRLLAVADVLERGALgkd---etRATNAIRYMNSYSKNPGRTWKTIQES-LQPYQAKLGTka--------tYLSKLVD 586 Bacillus halodu...
YP_867412    527 LYGRLLALADYLEEQALhaa--nehRATNAARLMQRFSQRPNATWLTIYDA-LLPYKNRLQVnkpg----lyiNMMRELD 599 Magnetococcus s...
YP_635131    464 VLGRLFAVLERLQGVALkd-----lNATIRDRYFGAASRNPVTVFPRLIQL-SVHHASKAGEng--------rWLERTKG 529 Myxococcus xant...
YP_002753896 482 VCGRLLALHDSLQWRTFdaaeeaqpNATVADRYYTLMMNSPAIGVAKVFDL-GRKHLSKLRKldaksgtsycdYFTRRIC 560 Acidobacterium ...
AAS82464     497 LSGRLLAVLEEAQKRASsy----tlRRTLVDRFYGAASTTPAATFGVLLRLsTTAHLPKVGQ-----------ELNQAVE 561 Thermus thermop...
AAK34352     510 LFGRLLAIFELIETLRYgldgnnndRITNAERYWTAYTGQPTKLMMLLENK-IKPYEEPLKLnrrg----swmKLEKEKE 584 Streptococcus p...

tigr:CT1133  555 GVFEGIGne--mPSHLSm-EDQARFAIGYYHQRQDFFKKKDSE 594 Chlorobium tepidum TLS
tigr:MCA0655 529 EIVDGIDa---fPPILSl-ADQGHFTIGYYHQRQALFTKTDRS 567 Methylococcus capsulatus str. Bath
AAQ58901     543 DIIHGLDap--lPRNLGi-AAQGQFAIGYYHQAHAYYHNKGGD 582 Chromobacterium violaceum ATCC 12472
AAS94334     573 EIIDNISd---fPVTMSs-DEQGLFMIGYYHQRKALFTKKNKE 611 Desulfovibrio vulgaris str. Hildenborough
AAN47886     528 EILAPLSgr--iPNTFSl-EEQGLFAVGYYHQRNELFKKKEEL 567 Leptospira interrogans serovar Lai str. 56601
NP_241204    587 EIGDQFE-----PGDFNnnPLTEQYLLGFYSQRRELYKKKEEE 624 Bacillus halodurans C-125
YP_867412    600 NVMNLFAi----ADYQNdaPLKGEYLLGYHCQRAVLWAKKGDK 638 Magnetococcus sp. MC-1
YP_635131    530 EVMALLPskdpfPPVFQp-EQQGLFAVGYYHQREAFFTKREAA 571 Myxococcus xanthus DK 1622
YP_002753896 561 ELEEHLGge--pPVQFDl-HDKARFALGFYHEKAPRFRARKAE 600 Acidobacterium capsulatum ATCC 51196
AAS82464     562 EILSRLDeaggfPRTLNl-VGQAEFALGFYHQRAHFRANRAGK 603 Thermus thermophilus HB27
AAK34352     585 EILELLNpl-leTETMEk-PLDYRFIFGYYAEKNYYYTKQNTE 625 Streptococcus pyogenes M1 GAS
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