Conserved Protein Domain Family
Cas3_I
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cd09639: Cas3_I 
CRISPR/Cas system-associated protein Cas3
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Links
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Statistics
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PSSM-Id: 187770
Aligned: 7 rows
Threshold Bit Score: 382.933
Created: 4-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P38036    309 LTVIEAPTGSGKTETALAYAWklid---qqiaDSVIFALPTQATANAMLTRMEAsashlfsspnlilahgnsrfnhlfqs 385 Escherichia coli K-12
NP_906084 255 LLLVRAPTGAGKTDAALLWAShqik---hrkaDRLIIAMPTRFTTNALALSVSStlsstgly---------------hss 316 Porphyromonas ging...
NP_247350 221 FVMLFAPCGRGKTEGALLWALnalk---nfkrNKIILAMPTQVTSNAMYDRLVKifgeenvglf-----------hgksf 286 Methanocaldococcus...
NP_143141 246 DVILYAPTGYGKTEAALLWANknahrtkkgisSRIFYILPYKASINAMHRRLLEmfkdpglv---------------gll 310 Pyrococcus horikos...
NP_070699  40 IFVIEAPTGYGKSTISATIAAysl-----qeeLKSIIAFPLRTLLEDQYNKFKGlfgn---------------------- 92  Archaeoglobus fulg...
NP_213254 239 CLVVVAPTGYGKTEAGFIFLK-----------DKGFFTLPFRVSANGIYERARAvfgenvgllh-----------sssli 296 Aquifex aeolicus VF5
NP_126702  40 FLVIQAPTGYGKTTLSLSLALhslkd--sslfDRVIHVLPMRSIIEDIDRTAKEafg----------------------- 94  Pyrococcus abyssi GE5

P38036    386 iksrAITEQGQEEAWVQCCQWLSQsnkkvFLGQIGVCTIDQVLISVLP-----VKHRFIRGLGIGRSVLIVDEVHAYDTY 460 Escherichia coli K-12
NP_906084 317 awtqNFSSKIDNGEIALEQARYYHnqarlLQTPITVCTIDHLLSSLTLc----DEEHQTITFALANACLVIDEADFYDQF 392 Porphyromonas ging...
NP_247350 287 iklrDSKEIEDEDDLEEIRDENFKgn--vFFKPITITTIDHVIYSFVHg----FSQADFALGNIQNSVIIFDEVHYYEKY 360 Methanocaldococcus...
NP_143141 311 hsssGIYLYSSSLEYKRLLSLYGK-----IYSPIKITTPFQIMKAFFG-----VGFFEITLVELINSLLIFDEIHAYESN 380 Pyrococcus horikos...
NP_070699  93 klgkRYMHNPDSPYLIKPVTLTTIdtlalTLFGIPPEDLDKAVKYWDGtssgsLGHYLFSQASVALSNIVLDEVHLLADS 172 Archaeoglobus fulg...
NP_213254 297 elmkKEEDELDTNTFEGIWKNYQHsk--sFAYPLTVCTPDQIMPFVFK-----FSGYEKYLALLSYSRIVIDELQVYAPY 369 Aquifex aeolicus VF5
NP_126702  95 --fsRTKMMGSSEEFLHLFPLNITtvdtfTWDILKLNTKKITQVERGRe----FGYDYLTQASILTSLVIFDEAHFILEE 168 Pyrococcus abyssi GE5

P38036    461 MNGL--LEAVLKAQA-DVGGSVILLSATLPmkqkqKLLDTYGLHTDPVeNNSAYPlinwrgvngaqrfdllahpeqlppr 537 Escherichia coli K-12
NP_906084 393 TQAN--ILVLLEVLK-YWKVPILLMSASLP-----DNIVQEYRKIGYDiKHILEDtsdier------------------- 445 Porphyromonas ging...
NP_247350 361 TLEH--LLTLFDILR-RMDIPHLLMSGTLP-----NFLMNNLEGYELVvDEEGLNykpfklkcs---------------- 416 Methanocaldococcus...
NP_143141 381 ILGI--ILAMLELLK-EKRAKALVMTATFP-----KFLEELIKSILNPkELKTPPeeadk-------------------- 432 Pyrococcus horikos...
NP_070699 173 TKSLn-FLFALMHAAiDNDQKLVLMSATIPea-lkKRIKEFNPDVCMVeFNESFDrkfveerrk---------------- 234 Archaeoglobus fulg...
NP_213254 370 TMAF--IVKALEVIK-DFGSKFMVMTATFP-----EFLRRFFEKMEIP-FKEFPElkprh-------------------- 420 Aquifex aeolicus VF5
NP_126702 169 PRMKtaFLAVLRFLM-ENNVPIIIMTATLSrg-yfELFKKYAQNNGYYfEPEPLVpdend-------------------- 226 Pyrococcus abyssi GE5

P38036    538 fsiqpepicLADMLPDLTMLEr-mIAAANAGAQVCLICNLVDVAQVCYQRLkelnnt----qvdidLFHARFTLNDRREK 612 Escherichia coli K-12
NP_906084 446 ---arfsliEKRDVSEISQMQd-lLQLCLDRGSAIIFANTVDRAQAYYQWFlengh-----eeeviLYHSRYTETDKIEK 516 Porphyromonas ging...
NP_247350 417 -enhliwkeDDEWKVNENIINe-iIENYKKGLSQAIILNTVERAREFYKAVrdkv--------paiLYHSQFAYKDRVKK 486 Methanocaldococcus...
NP_143141 433 ----ftrhrVNVIDGDIRTLD---SEEFPGPRPILIACNTVNTSIEVYSKLkesg-------anvmLIHGRFTYGDREDK 498 Pyrococcus horikos...
NP_070699 235 -kkyrinliALASVEKFGSLErilLEGSKKFSKITVVFNTIGDAVYFYNNIkekip-----efkklLLHSRFSEMDREKK 308 Archaeoglobus fulg...
NP_213254 421 -----nvklLEDTLGSESSINl--IRSLSEEGKVLVIVNTVRKAQELSLLLna------------pVLHSRFLQKHRAKK 481 Aquifex aeolicus VF5
NP_126702 227 ----pfikrESKKNFEIQFKTgnpLDFIDSAKRNAIIVNSVKRAVEIFDQAkedapklgfeeeeimLIHGRMKPSHKARL 302 Pyrococcus abyssi GE5

P38036    613 e-NRVISNFGKngkr--nvgrILVATQVVEQSLDVDFDWLITQHCPADLLFQRLGRLHRhhRKYRpagfeIPVATILLPD 689 Escherichia coli K-12
NP_906084 517 e-AQLLLRLGRsawdndrangVAILTQIGEMSVNISADIMISDLCPIDRLTQRCGRLCRfsRKIG-----DLYIIRPMRE 590 Porphyromonas ging...
NP_247350 487 edEIFTLEEMRksqn---kpyVIVATQVIEISLDMSVDVMYSELSPPDALGQRAGRLHRkgKDWRen--gKEYKLKIFLP 561 Methanocaldococcus...
NP_143141 499 e-KMLMNSLSDf--------dFVVATQVIEVSLDIDFGSIITEPAPLDALIQRFGRVNRrgFGKPr----DVYVLTKGSE 565 Pyrococcus horikos...
NP_070699 309 --AELLAEMKKse------kfVIVTTQVIEAGVDISSNLFITEIAPASSLIQRLGRFLRygEREG-----EVYIWYEVDD 375 Archaeoglobus fulg...
NP_213254 482 e-EEIKEFFSSge------kgVWVTTQLAEVSLDLDADFLVTELSTIDSLIQRMGRCNRkgIKDIen--pNVYVFTQEPS 552 Aquifex aeolicus VF5
NP_126702 303 --IEKLREWKNke------sfLIIGTQAVEAGVDFSVDVMITDAAPINSLIQRFGRVARydEKNA-----EIIIIEDAPV 369 Pyrococcus abyssi GE5

P38036    690 Gegygr-------hehiYSNVRVMWRTQQHIEEL 716 Escherichia coli K-12
NP_906084 591 GnlfpapyyqnvgpsqkLEPNDALIQTDELLEKG 624 Porphyromonas gingivalis W83
NP_247350 562 Ykh-------------lPYSKELIEKTINHIKFY 582 Methanocaldococcus jannaschii DSM 2661
NP_143141 566 Ddk------------nvYRPYDVVEETVKILREI 587 Pyrococcus horikoshii OT3
NP_070699 376 Rgelarw----kddrykVYDYSLTALTLEKLAEM 405 Archaeoglobus fulgidus DSM 4304
NP_213254 553 Gkg-------------sVYPKELLELTRKALTEG 573 Aquifex aeolicus VF5
NP_126702 370 H----------------PYDGKKVERTIALMKES 387 Pyrococcus abyssi GE5
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