Conserved Protein Domain Family
Cas4_I-A_I-B_I-C_I-D_II-B
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cd09637: Cas4_I-A_I-B_I-C_I-D_II-B 
CRISPR/Cas system-associated protein Cas4
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster
Links
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Statistics
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PSSM-Id: 187768
Aligned: 16 rows
Threshold Bit Score: 131.786
Created: 2-Feb-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
BAB67755    2 VTVSDVKQYh-----FCKAIPWINYv----MGYREPSTfsm----eeGKKISYeevvks------lnlttpVKYEVCLSY 62  Sulfolobus tokodai...
NP_662022   8 IALSALQHYv-----FCPRQCALIH-----LEQVWSENlyt----aeGREMHEradsavt----syregvkVTRSVPLRS 69  Chlorobium tepidum...
AAL63707   53 LSPSVINDYe-----YCPRLLWTQYk----LGLKLFSIdsav-aivkGRLLHEryeravs-----ifdnviAEYKIEIGD 117 Pyrobaculum aeroph...
BAB77933    6 IPIAALNQYa-----YCSHRCWRMFc----AGEFIDNQyt-----ieGTTLHDrvhttse----nqreetwQVRAIWLKS 67  Nostoc sp. PCC 7120
NP_213253  15 FTGTQVAYYv-----ICKRKLWLFS-----KGLSYESEsef---velGKLLDEraf-------------krEKEEVEWGE 68  Aquifex aeolicus VF5
NP_147814   2 RPVSMLKEYa-----YCPRVAYYMEv----LRPSYRPTepm----nlSREIYSvdhvrgilr-ssgfrivkEEWAVPLRS 67  Aeropyrum pernix K1
BAB64972    3 ISGVTVKHYa-----YCPHIVRLEA-----LGFSERVSeam----leGQLIDKekevs---------flftKYKEIIRKP 59  Sulfolobus tokodai...
BAB67441   24 DNTLYVTDLi-----RCPLKIQYEKty-keLAISEVFTpst----ilGDMVHEglenfiknnfsnsqveveIEREIPVNN 93  Sulfolobus tokodai...
NP_143585  11 FGGALMIEFyasealICPRRVWFRL-----KGIPEKWPevakprlekGMKIHEvlgkvlk-----drfdveLEKSVIIRF 80  Pyrococcus horikos...
NP_147188  20 IAPSRLRTFv-----YCPRLYFFEThmpaeRGLTERVRmi------lGTVYHAaaalld------rirgsrAEEPVEASI 82  Aeropyrum pernix K1

BAB67755   63 ng----lsGCIDILAGDRKy-----TVVEVKafkrg------nfshFRYQLLAYAYLVRKrlg------------iveRA 115 Sulfolobus tokodai...
NP_662022  70 avl--gvsGVADVVEWHRReggfepFPVEYKrgkpk------khdaDKVQLCAQAMCLEEmrsc----------aipsGA 131 Chlorobium tepidum...
AAL63707  118 l------vGVVDIVMRKGNe----yIPVEIKtgla-------sreaHRRQLQIYIHMLKAr----------------yGY 164 Pyrobaculum aeroph...
BAB77933   68 dky--qliGKSDLIESADGq----fYPVEYKrgrkg------ewdnDELQVCAQALCLEEmtgq----------tittGY 125 Nostoc sp. PCC 7120
NP_213253  69 n------pVKIDFLTGEEGl-----VVHEVKhspk-------leeaHVLQVKYYLWFLEKsgvk-----------vshGI 119 Aquifex aeolicus VF5
NP_147814  68 krl--glqGVADGVVVEGSlg---iIVVEAKlsvrsnrwlhtrgrhVIFQAAAYALALEEtrgy----------svdyLA 132 Aeropyrum pernix K1
BAB64972   60 vyrwkdliGSPDFVLHAYNy----yTPLDVKagkv-------prldHKYQILFYSYIMDRlgmn-----------vkeAM 117 Sulfolobus tokodai...
BAB67441   94 kqv--kikGRIDAIAEIDGe----kVVIEIKsaradk---glphehHKVQLQIYLWMTGIk----------------kGL 148 Sulfolobus tokodai...
NP_143585  81 p------kLGMEIHGKIDVyk---eFPIEIKgksyip---sspidyHLAQLNLYLRGVNAeygylyyvkltddpwraiSD 148 Pyrococcus horikos...
NP_147188  83 ggy--liaGRPDSWRMDDGe----vLVVERKsgrgpk---vgvwlsDLLQAVAYAIALSRrsna----------raarVK 143 Aeropyrum pernix K1

BAB67755  116 ILVMEGKKvle-------iepTEEHYRYIENVVKKIEEIVNSEKLPavn-veKCDFCQYRRICP 171 Sulfolobus tokodaii str. 7
NP_662022 132 LFYGQTMRrld-------vvfDEVLRSKTVAAAAGVHGLFSLGVTPhpefgpKCKLCSLVDECL 188 Chlorobium tepidum TLS
AAL63707  165 LVYRNRVE-------------KVERDSKAVEMLYKIKSVLQMDKPPn----vNCKSCPFKYICK 211 Pyrobaculum aerophilum str. IM2
BAB77933  126 IYYAHSHQrql-------veiNQELRKSAIATIQAVTNLLTTGIMPipnyskRCQGCSLNLQCL 182 Nostoc sp. PCC 7120
NP_213253 120 IHYPKQRKvlr-------velTQEDRKVIVEALENIQKVLLEEKPPevikkpYCKKCAYYEFCY 176 Aquifex aeolicus VF5
NP_147814 133 IVSLEDSKtyv-------vkmSPSLRRDVIRLADDMNKTLDDGLEPppkpgrKCVACRFRRVCQ 189 Aeropyrum pernix K1
BAB64972  118 LYYIAGKKlir-------lqySETEKRFVEKLIGWIREAMNSEVKIvqk-keKCENCGFFSYCK 173 Sulfolobus tokodaii str. 7
BAB67441  149 LVYITPDRvtey------evnEPADEVGVIRLAEETLKRTKVPRYPw-----ECGYCVYSSVCP 201 Sulfolobus tokodaii str. 7
NP_143585 149 IVFDSFPLikgnglkifevpyDEVLFKETVKYFYEIKLYLENDELPpawkgpHCKFCPYNYICL 212 Pyrococcus horikoshii OT3
NP_147188 144 IVYLRGGSgey--------svGEDLVYTAMRAMEDMRLAAEGILPYphrsprKCAICPYREECY 199 Aeropyrum pernix K1
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