2IVF


Conserved Protein Domain Family
DOMON_EBDH
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cd09623: DOMON_EBDH 
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Heme-binding domain of bacterial ethylbenzene dehydrogenase
Ethylbenzene dehydrogenase (EBDH) is a bacterial molybdopterin enzyme. It catalyzes anaerobic hydroxylation of alkylaromatic compounds to secondary alcohols. The DOMON domain in EBDH and related proteins, typically called the gamma subunit, binds a heme; its function in the catalytic mechanism is unclear. It co-occurs with a molybdopterin-binding subunit and an iron-sulfur protein. This family also contains heme-binding domains of dimethylsulfide dehydrogenase, selenate reductases, and chlorate reductase.
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Statistics
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PSSM-Id: 187681
Aligned: 22 rows
Threshold Bit Score: 186.823
Created: 30-Oct-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heme bindingbeta subunit
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:2IVF: Aromatoleum aromaticum Ethylbenzene dehydrogenase gamma subunit binds heme, contacts at 4 A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                         #              
2IVF_C         3 AKRVPGgke-------llLDLDAPi------------------wAGAESTTfe--------mFPTPLV-----------M 38  Azoarcus sp. EB1
CAJ72454     247 YKETLSde--------erWSLAHYvesl------------skkmASDVVVKvkl-----leeGELPDHp----------A 291 Candidatus Kuen...
CAJ72449       1 MKKFYRllgsssvallgcLFLSVAlciaeeaegvkgvaeeeltpAKEVLNVky-------mqIDVPAHitv------gaL 67  Candidatus Kuen...
EDP74001       5 FKATLAtl--------aaFSISASasey------------sdfyKYEVLNAkk-------vsKELTTNv----------N 47  Hydrogenivirga ...
YP_002121004   1 MNRYLLf----------sLLIFTSmsl---------------sfGQELISKsv--------eGEIPLNp----------M 37  Hydrogenobaculu...
YP_001528082   1 MEKVIC------------KKIATA--------------------TKELLNCd----------SSVWQSgkavletaatpL 38  Candidatus Desu...
EEP61348       1 MKKKLTlft------isaLVLSSNagt--------------dnfNNDVLEAkq--------lSKIDAQs---------lS 43  Sulfurihydrogen...
YP_001357279   1 MRRVVQla--------aaLSLAASvs-----------------iAGNVVTAvkvksfkylkcGSKLVR-----------K 44  Nitratiruptor s...
YP_160315      3 VKRIDAgdd-------tlLDLAASv-------------------WNDAQAMrl-------pmAPVPLV-----------L 38  Azoarcus sp. EbN1
ADR35148       1 MKKLLTt----------iLSLGVA--------------------ASAALAGdl-------slTAVKVSdkld---tvsaD 40  Sulfuricurvum k...

Feature 1                               #                                                        
2IVF_C        39 VKEVS----------------PFLALseg----------hgVIKRLDVAALHNgSMIALRLKWASe--kHDKIVDl---n 87  Azoarcus sp. EB1
CAJ72454     292 DEVWGlaap---------leiPLAGQivahp-----rlwepAIDSMMIRGLYNdREIAFLVEWDD----RTNLQEd---- 349 Candidatus Kuen...
CAJ72449      68 EGAFKnaegvqvklqkqdkafPNGGG---------------SVNSAEIKAIHDgITIYFQVIWDDa---TDNKQAia-tq 128 Candidatus Kuen...
EDP74001      48 DSVWKtvpgk------yvylyPQVSVrlndkka-nslipkkNLRRALVKVAYNdEVIAVYVSWRDd---TPSVQAkydtd 117 Hydrogenivirga ...
YP_002121004  38 ADIWNk--------------aPSTTIqlsgqaivapmdlnpATKSITVKSIHNsKYIAFLLSWSDphpsTFRVND----- 98  Hydrogenobaculu...
YP_001528082  39 ANQPS----------------PYIKGvyde-------tkigAVKKITIKAVHNgKDIVFYCEWESg---KPNKEIgd-in 91  Candidatus Desu...
EEP61348      44 SVPAKkiv-----------lyPQYSVrlndkna-neivekeQPVEAEIAVGYNqKEIGILIRWKDe---TKSVQPalatn 108 Sulfurihydrogen...
YP_001357279  45 YAKFQkvv-----------vyPQTTLhfndkka-nelnkdaKAKVIEVAAFTDgRNIAIVTRWPDk---TKDVYKgyksd 109 Nitratiruptor s...
YP_160315     39 VQDWS----------------PFLAKsed----------hgANKSLDVAALHNgKSLAVRLKWASe--kHDQMPDl---d 87  Azoarcus sp. EbN1
ADR35148      41 SALWSkakfs------tvdlyPQTAIefndkea-ieankanKGKKVQVAALHNgSEIAVLVKWADg---SKNVQGikctd 110 Sulfuricurvum k...

Feature 1              # #              ## #          #                                          
2IVF_C        88 SFVDGVGAMFPVA------RGAQAVTMGATGRPVNAWYWKAna------------------------------------- 124 Azoarcus sp. EB1
CAJ72454     350 IFRDAVSLQFPVKip--esLKKPYFGMGDSGGVVNLWQWKAcwke----------------------------------- 392 Candidatus Kuen...
CAJ72449     129 EFRDGAALMFPLGkitispEEPFSPRMGDRQKPVNLWHWKAdweadllatggieecparypnmhddfstnphsvnyhkgv 208 Candidatus Kuen...
EDP74001     118 SYADGVSIEVPNKfg--kgITLPYIGMGDENHPVTVYLQKTvag------------------------------------ 159 Hydrogenivirga ...
YP_002121004  99 KFSDAVALEVPLKp-----DNTTPITMGGNGKEVVILQWAAyrqynitkgfadipkiepyyytgyiypqakp-pyaypkd 172 Hydrogenobaculu...
YP_001528082  92 VFPDGVALLFPFKd----iDKTPINEMGTQDYPTNAWYWRPdf------------------------------------- 130 Candidatus Desu...
EEP61348     109 KYGDGVAVEFPTVyg--kgKTLAYVGMGDANHPVMVYLKKAveg------------------------------------ 150 Sulfurihydrogen...
YP_001357279 110 IYPDGFAVQFASDas--kpEKLPYIGMGSDGRPVAIYLRKAyaqgvyepnghgdvahqvnehn----------------- 170 Nitratiruptor s...
YP_160315     88 SFVDGAAVLFPLV------EGAPAMTMGAKGKPTNAWFWKAnq------------------------------------- 124 Azoarcus sp. EbN1
ADR35148     111 TYSDGFALQFAGStk--kaQPLPYIGMGSEGRPVVVHLQKAtekvyepngnkdvstqinrqqt----------------- 171 Sulfuricurvum k...

Feature 1                                   #    #    # #                                        
2IVF_C       125 ----------------------nEPMEIVAEGF--SAVRRMkdk----------agsDLKAVAQHRn--GEWNVILCRSM 168 Azoarcus sp. EB1
CAJ72454     393 --------------------gfgSIAEMPANEP--GEIVELnakgfkkisiqspenqDVMGEGLHDn--GRWKVVFKRPL 448 Candidatus Kuen...
CAJ72449     209 iqsaaelsggyaahnllslprgrAVEDLNAEGF--GTLTSQdh-------------qDVDGCSKFEn--KKWTVVFCRSL 271 Candidatus Kuen...
EDP74001     160 ---------------------rdYQKVFVSEGF--GSLTEIke-------------eGTDISMKYNkqtHLWTAVFVRPL 203 Hydrogenivirga ...
YP_002121004 173 wnnkyaqdyvggkvpywkntrdtSVIEFIADGY--TTTTWRkh-------------qEAKGVGVYKn--GKWYVEIIRPF 235 Hydrogenobaculu...
YP_001528082 131 ---------------------eeKPKNQVSHGLstSLYTEKs---------------SISSYSRWAn--GKWCVVMARPM 172 Candidatus Desu...
EEP61348     151 ---------------------keYKKSFISEGF--GTMTEIqe-------------kGYNFTMQYDdskKEWTAVIVKPL 194 Sulfurihydrogen...
YP_001357279 171 -tnyfgkslkkfekevkklgvrpYQRAFVSEGF--RSMTEIkdn-----------saNFRTDMYYVkkyHKWGGMVVRPI 236 Nitratiruptor s...
YP_160315    125 ----------------------kSAMEVVAESF--TAVQRLegk----------atsDLKTVAQHQn--GEWQVIFRRSL 168 Azoarcus sp. EbN1
ADR35148     172 --gvfgkelaeydakvaslantdFERVFVGEGF--RSLTEIkd-------------kSVKSNASMKyenKGWTGTLVRPL 234 Sulfuricurvum k...

Feature 1                              ### #       ## # # #       
2IVF_C       169 ATgd---gLAKLQa--gGSSKIAFAVWSGgnAERSGRKSYSGeFVDFEI 212 Azoarcus sp. EB1
CAJ72454     449 KTed---gKKDIQfeigKLIPIAFAVWDGsnGDAGSQKSVSS-WYYILL 493 Candidatus Kuenenia stuttgartiensis
CAJ72449     272 NTg----dPLDVQfvpgESTYFNMAVWNGdrEDRNGQKNISIqWHPLSL 316 Candidatus Kuenenia stuttgartiensis
EDP74001     204 KTe-----NSNLKa---GLVPIAFAIWDGkfQERDGNKSLSR-WKFIRL 243 Hydrogenivirga sp. 128-5-R1-1
YP_002121004 236 NIk----gALNPEwgpnSKTFIDFAVWQGyaKERDSRKAISYaWIPLII 280 Hydrogenobaculum sp. Y04AAS1
YP_001528082 173 KAtqpgeeTVDLMp--gKAIGFGIAVWEGsnGERGGIKAFSKeWRELVI 219 Candidatus Desulfococcus oleovorans Hxd3
EEP61348     195 KTp-----DLNLAs---GMVPVAFAVYDGdsLNRDGNKRISS-WKFIKI 234 Sulfurihydrogenibium yellowstonense SS-5
YP_001357279 237 KDa----yAKPTK----NEFAVAIAVWDGkeLQRDGLKRLSS-WIAVRL 276 Nitratiruptor sp. SB155-2
YP_160315    169 ANrd---gLVQLPi--gGNGKIAFALWNGgnKERSGRKSFSGdFMDFSI 212 Azoarcus sp. EbN1
ADR35148     235 KDd-----YISAS----GTLPVAIAVWDGakHGRNGLKLLSS-WVAINL 273 Sulfuricurvum kujiense DSM 16994

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