3LL2,2GUD,2NUO


Conserved Protein Domain Family
griffithsin_like
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cd09614: griffithsin_like 
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Jacalin-like lectin domain of griffithsin and related proteins
Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.
Links
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Statistics
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PSSM-Id: 187710
Aligned: 10 rows
Threshold Bit Score: 115.187
Created: 12-Nov-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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sugar binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding site [chemical binding site]
Evidence:
  • Structure:2GUD: Griffithsia griffithsin in complex with mannose, contacts at 4 A
  • Structure:3LL2: Griffithsia sp. Q66D336 griffithsin binds a high-mannose branched carbohydrate, contacts at 4 A
  • Structure:2NUO: Griffithsia griffithsin in complex with glucose, contacts at 4 A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ##                      ### #                      ##                      
3LL2_A          6 KFGGSGGSPFSGsg-------lSSIAVRSGSYLDAIIID----------GVHHGGSGGn--LSPTFTFGsGEYISNMTIR 66   Griffithsia s...
2GUD_A          6 KFGGSGGSPFSGl---------SSIAVRSGSYLDAIIID----------GVHHGGSGGn--LSPTFTFGsGEYISNMTIR 64   Griffithsia
2NUO_A          7 KFGGSGGSPFSGl---------SSIAVRSGSYLDAIIID----------GVHHGGSGGn--LSPTFTFGsGEYISNMTIR 65   Griffithsia
YP_001098389  821 GGGGGGWSDAAQcqk----qhvVAFNVSSGKRLDGIQFQy--------aNGQWGAVHGklkNKKAYALPaGQYIVRVDYR 888  Herminiimonas...
YP_001533411    7 TFGGRGGDAFDIag-------fEAIGLSSASRIDELRLD----------NARYGGNGGk--KESGLSFSsDEYINEMVIR 67   Dinoroseobact...
YP_001657640 1029 TPTPLCLKDLPKi---------AAVQLHGGDYVDQLSTIysyq--agaqTFSHGGSGGg--PCFNLNLAvDEFISSVSGT 1095 Microcystis a...
YP_001657640 1614 NPTPLPLSQLPLl---------ISVSIWGGDYVNQIGTTyqsl--ngtqQFAHGKGTVn--AWPALNLSkGEFITEITVI 1680 Microcystis a...
YP_002548932  360 GDGGSPFDDIDIstyisrktrvSAIGLRTGNRTDQLRTSyiddt-gqfsTKTHGGGGGs--DRGTLQILeGQFITRISGR 436  Agrobacterium...
YP_003071839   33 PFADNPPTDFSQi---------HDITLCGGSVVDSISTNiedvygnvqsYGKKGGNGG---TCSTLYFYsGEYITSVTGR 100  Teredinibacte...
CBJ36457      373 GNGGSPFNDVDIntyiqnqtyvSAVQLRTGSEVDALIVTyqatakstsmQTYHGGGGGs--FSQTLQVRpGQFIKKLSGR 450  Ralstonia sol...

Feature 1          ### #                   # #                    ### #        
3LL2_A         67 SGDYIDNISFETNMg-RRFGPYGGSG-GSANTLS---NVKVIQINGSAGDYLDSLDIYYEQ 122  Griffithsia sp. Q66D336
2GUD_A         65 SGDYIDNISFETNMg-RRFGPYGGSG-GSANTLS---NVKVIQINGSAGDYLDSLDIYYEQ 120  Griffithsia
2NUO_A         66 SGDYIDNISFETNMg-RRFGPYGGSG-GSANTLS---NVKVIQINGSAGDYLDSLDIYYEQ 121  Griffithsia
YP_001098389  889 GGGSMDAVGFTTNTg-TSYGPFGGGG-GSAGTYTvtpGQKLGCMAGRSGSEVDQLIFSSTG 947  Herminiimonas arsenicoxydans
YP_001533411   68 SGSRVDRIELRTNR--GRELVHGGNG-GTRHELT---DIRVLGLGGRSGSELDQLAVHFIR 122  Dinoroseobacter shibae DFL 12
YP_001657640 1096 CGDYINQLTFQTTSsqDYTFPLSPSStGNTISWTaadNQILLGFQGSSGDYLNQLQLIVLS 1156 Microcystis aeruginosa NIES-843
YP_001657640 1681 YGDYVNAVQFSTNYgqTSLLAPASCDsASVATWSvpgNCTLIGFQGSSGDYLNQLQPVCLS 1741 Microcystis aeruginosa NIES-843
YP_002548932  437 SGNRLDQVQFQISD--GRGIGGGGGG-GSAFDWSppsGSFVMGFSGRSGNEVDRLQVYYGK 494  Agrobacterium vitis S4
YP_003071839  101 YGSRVDSMVITTNY--GRTLSKGGNGgGGDFKYTandQFQIAGFAGRSGSKLDAVGVIYLR 159  Teredinibacter turnerae T7902
CBJ36457      451 SGSRVDQLRITLDD--DRSVAGGGGG-GSPFDWQvpsGSVVMGFAGRSGSRLDQVEAVYAT 508  Ralstonia solanacearum CMR15

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