2GYT


Conserved Protein Domain Family
SAM_DLC1
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cd09591: SAM_DLC1 
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SAM domain of DLC1 subfamily
SAM (sterile alpha motif) domain of DLC1 (Deleted in liver cancer) protein is a protein-protein interaction domain located at the N-terminus. Proteins of this subfamily do not form dimers/oligomers through their SAM domains. They participate in regulation of cell migration. SAM domain of human DLC1 protein contains the EF1A1 (eukaryotic elongation factor) binding motif, thus SAM facilitates recruitment of EF1A1 to the membrane periphery and suppresses cell migration.
Links
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Statistics
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PSSM-Id: 188990
Aligned: 3 rows
Threshold Bit Score: 121.667
Created: 30-Apr-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Comment:This key protein binding motif mediates interaction of SAM_DLC2 with EF1A1 protein (based on mutagenesis).
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              ##                                     
2GYT_A         17 KEACDWLRATGFPQYAQLYEDFLFPIDISLVKREHDFLDRDAIEALCRRLNTLNKCAVMK 76   human
XP_420693     498 KEACDWLRAAGFPQYAQLYEDLLFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMK 557  chicken
XP_002938104    9 KEACDWLRAAGFPQYAQLYEDLQFPINIELVKNDHEFLDRDAMESLYRRLNTLNKCAAMK 68   western clawed frog

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