Conserved Protein Domain Family
SAM_HARP
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cd09587: SAM_HARP 
SAM domain of HARP subfamily
SAM (sterile alpha motif) domain of HARP (Harmonin-interacting Ankyrin Repeat-containing) proteins, also known as ANKS4B, is a protein-protein interaction domain. Proteins of this subfamily have an N-terminal ankyrin repeat region and C-terminal SAM. In mouse epithelial tissues, HARP protein interacts with the PDZ domain of harmonin. This scaffolding complex facilitates signal transduction in epithelia. HARP was found co-expressed with harmonin in a number of epithelial cells including pancreatic ductal epithelium, embryonic epithelia of the lung, kidney, salivary glands, and cochlea.
Links
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Statistics
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PSSM-Id: 188986
Aligned: 4 rows
Threshold Bit Score: 112.227
Created: 3-May-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative polypeptide binding site [polypeptide binding site]
Evidence:
  • Comment:SAM domain of SANS (also known as USH1G) protein binds PDZ domain of harmonin via synergistic interactions of two binding regions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     ## # ### ## #                                            ##   #    
Q8K3X6    350 DATPLEVFLQSQHLEEFLPIFMREQIDLEALLLCSDEDLQNIhmqLGPRKKVLSAIDKRKQVLQQPG 416 house mouse
Q8N8V4    344 DATPLEVFLLSQHLEEFLPIFKREQIDLEALLLCSDEDLQSIqmqLGPRKKVLNAINRRKQVLQQPG 410 human
XP_424609 330 ECTPLEVFLASQMLDEFLPVFMREKMDLDALMLCSDEDLQNIqveLGPRKKILSAVSKRKQAFRDPG 396 chicken
CAG11420  352 DSSPLDVFLSAISLQEFAVAFSKEHLDMEALMLCTDEDLKGIriqLGPRKKILEAVARRSHTLKTPG 418 Tetraodon nigroviridis

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