Conserved Protein Domain Family
SAM_DDHD2
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cd09585: SAM_DDHD2 
SAM domain of DDHD2
SAM (sterile alpha motif) domain of DDHD2 group is a potential protein-protein interaction domain. DDHD2 proteins contain at least two domains:a SAM domain and a predicted metal-binding domain. Phospholipase A1 activity was demonstrated for the mammalian DDHD2 protein. Mutation of the putative catalytic serine resulted in elimination of activity. Unlike SEC23IP, DDHD2 proteins do not have an N-terminal proline-rich region and correspondingly they are not able to interact with Sec23p/Sec24p complex. Overexpression of DDHD2 is the cause of dispersion of ER/Golgi intermediate compartment and dispersion of tethering proteins located in the Golgi region, leading to aggregation in the endoplasmic reticulum.
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Statistics
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PSSM-Id: 188984
Aligned: 4 rows
Threshold Bit Score: 123.712
Created: 20-Sep-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O94830    379 NIVMDQGDTPTLEEDLKKLQLSEFFDIFEKEKVDKEALALCTDRDLQEIGIPLGPRKKILNYFSTRKNS 447 human
XP_424389 368 EVTSSSRGAEEVKEILKKLDLSEYCPVFEKEKIDGEALFLCAERNLEEMGIPLGPRMKLLHYISSRREV 436 chicken
AAI26030  397 SRSDSQGDTPRLSDVLQQLELTEYCSVFEREKIDMEVLALCSENDLKDLEIPLGPRKKILQYIRHRGWQ 465 African clawed frog
CAG08555  419 PADKYQISCHTLEQTLSRLGLQQYLDIFQKESLDLESLALCQDSDLKDLGIPLGPRKKILNHVRRIFLL 487 spotted green pufferfish
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