Conserved Protein Domain Family
SAM_sec23ip

cd09584: SAM_sec23ip

SAM domain of sec23ip

SAM (sterile alpha motif) domain of Sec23ip (Sec23 interacting protein) group is a potential protein-protein interaction domain. Sec23ip proteins (also known as p125) contain an N-terminal proline-rich region, a central region containing a SAM domain and a C-terminal region with a predicted metal-binding domain. Sec23ip interacts with Sec23p/Sec24p part of COPII-coated vesicles complex involved in protein transport from the ER to the Golgi apparatus. The proline-rich region plays an essential role in this interaction. Overexpression of Sec23ip leads to disorganization of ER/Golgi intermediate compartment.

Links

Source:	cd09516
Taxonomy:	Euteleostomi
PubMed:	6 links

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl15755

Statistics

PSSM-Id:	188983
Aligned:	5 rows
Threshold Bit Score:	124.155
Created:	20-Sep-2010
Updated:	2-Oct-2020

Structure

PubMed References

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

NP_009121     638 DLVVENKEVLTLQETLEALSLSEYFSTFEKEKIDMESLLMCTVDDLKEMGIPLGPRKKIANFVEHKAAK 706  human
NP_001091152  634 SDSEQQKPLPSLREALESLSLAEYSSVFEKEQIDMESLLMCTVDDLKEMGIPLGPRKKIAKFVQTKRKA 702  African clawed frog
CAG04716      619 RLNEDGEDFEDLLSVLQHLGLSEYKTTFDDEKIDIESFLLCTIEDLKEMGIPLGPRKKIAKFVKERVNK 687  spotted green pufferfish
NP_001070847  620 AKEEEEEETGSLSSVLEAIGLSEYLSIFENEKIDVESLLMCTVDDLKEMSIPLGPRKKLANFIKEKSAK 688  zebrafish
XP_002188458  627 CEAEAEEDVPTLQKTLEMLSLAEYVSTFEKERIDMESLLMCTVDDLKEMGIPLGPRKKIANFVKDRAAK 695  zebra finch

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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Conserved Protein Domain FamilySAM_sec23ip

Conserved Protein Domain Family
SAM_sec23ip