Conserved Protein Domain Family
SAM_Scm-like-3MBT3,4
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cd09582: SAM_Scm-like-3MBT3,4 
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
SAM (sterile alpha motif) domain of Scm-like-3MBT3,4 (Sex comb on midleg, Malignant brain tumor) subfamily proteins (also known as L3mbtl3,4 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are predicted transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain three MBT repeats and Zn finger domain. Murine L3mbtl3 protein of this subfamily is essential for maturation of myeloid progenitor cells during differentiation. Human L3mbtl4 is a potential tumor suppressor gene in breast cancer, while deregulation of L3MBTL3 is associated with neuroblastoma.
Links
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Statistics
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PSSM-Id: 188981
Aligned: 16 rows
Threshold Bit Score: 119.303
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putativeputative
Feature 1:putative oligomer interface ML [polypeptide binding site]
Evidence:
  • Comment:The mid-loop (ML) surface of the SAM domain of Ph protein interacts with the end-helix (EH) surface of the SAM domain of Scm protein forming heterodimers.
  • Comment:SAM domains of Scm and Ph proteins can form head-to-tail homooligomers via interactions between the mid-loop (ML) and end-helix (EH) surfaces.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      ### ##  ##  ##    #                  
Q8NA19        540 VARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFR 605  human
XP_792284     869 VARWTMDEVASFVQKLPGCQEHASKFADEQIDGEAFLLLTQSDIVKIMTIKLGPALKIYNAILILK 934  purple urchin
XP_002609644  877 ISKWTIEQVADFVKTLPGCEEMGNVFKDEQIDGEAFLLLNQADIVKIMNIKLGPAVKIYNSILILK 942  Florida lancelet
XP_391871    1150 PRRWSNEEVIKFIQSVPNCKEIGNIFRQHNIDGEAFLMLTQEDLVSLLGLRLGPAIKLYNSIVLLR 1215 honey bee
XP_001849673  352 PLRWSVDEVASYVERFPGCGLVASQIRDEQINGSAFLSLTQDDLVKYLDVKLGPAIKLYNRIIHLR 417  southern house mosquito
CAI12008      664 VASWSIDEVIQFIQGLPGCKEQVRTFRDEQIDGEAFLLLTQVDLVKILSIKLGPALKIYNSILMFK 729  zebrafish
NP_001089886  598 VGKWSADEVAQFVHQLPGCKDQSSVFKDEQIDGEAFLLLTQSDLVKILGLKLGPALKIYNSILMFH 663  African clawed frog
XP_002404198  982 VAGWSVAQVATFIGSLPGCQATAKIFRDEQIDGEALLLLGQGDLVRTLRLKLGPALKVYSCILRFR 1047 black-legged tick
XP_002122746  801 VKTWSIEKVAEFINVLTGKTECGTFFIDHEIDGESLLLLTQEDILKILKIKLGPAVKIYNAILMFK 866  Ciona intestinalis
XP_308935    1629 PLHWTTDEISCYVERLPGCEQYAKKIRQEELTGRSFLSLSQSDLIDYLGVKIGPAIKMYNRIIRLR 1694 Anopheles gambiae str. PEST

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