1PK1


Conserved Protein Domain Family
SAM_Ph1,2,3
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cd09577: SAM_Ph1,2,3 
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SAM domain of Ph (polyhomeotic) proteins of Polycomb group
SAM (sterile alpha motif) domain of Ph (polyhomeotic) proteins of Polycomb group is a protein-protein interaction domain. Ph1,2,3 proteins are members of PRC1 complex. This complex is involved in transcriptional repression of Hox (Homeobox) cluster genes. It is recruited through methylated H3Lys27 and supports the repression state by mediating monoubiquitination of histone H2A. Proteins of the Ph1,2,3 subfamily contribute to anterior-posterior neural tissue specification during embryogenesis. Additionally, the P2 protein of zebrafish is known to be involved in epiboly and tailbud formation. SAM domains of Ph proteins may interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with the SAM domain of Scm (sex comb on midleg) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome.
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Statistics
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PSSM-Id: 188976
Aligned: 13 rows
Threshold Bit Score: 109.799
Created: 5-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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oligomeroligomer
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface ML [polypeptide binding site]
Evidence:
  • Structure:1PK1_A; Drosophila SAM_Ph/SAM_Scm complex, contacts at 4A.
  • Comment:The mid-loop (ML) surface of the SAM domain of Ph protein interacts with the end-helix (EH) surface of the SAM domain of Scm protein forming heterodimers.
  • Comment:The SAM domains of Ph proteins of Drosophila can form head-to-tail homooligomers via interactions between the ML and EH surfaces.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      ##### ##  ##   #    #                   
1PK1_A         12 PPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAXGXKLGPARKIVAKVESIKE 80   fruit fly
Q8NDX5        914 TEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKE 982  human
XP_002610914  950 PNPARWSVEEVWEFIRSLPGCSDFADEFRAQEIDGQALMLLKEDHLMSAMNMKLGPALKICARINSLKQ 1018 Florida lancelet
Q8IXK0        789 SEPTKWNVEDVYEFIRSLPGCQEIAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKIYARISMLKD 857  human
Q8QHL5        758 SDPTKWNVEDVYEFICSLPGCHEIAEEFRSQEIDGQALMLLKEDHLMSTMNIKLGPALKIFARISMLKD 826  zebrafish
P78364        935 SNPSRWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKE 1003 human
NP_001006249  922 SSPSRWSVEEVYEFIASLQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINILKE 990  chicken
Q4V7W5        275 SDPTKWNVEDVYDFVRSLPGCQEISEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKLYARISMLKD 343  African clawed frog
XP_002403529  252 KSPRIWTVQEVADYIQELPGCTDYAEEFRSQEIDGQALLLLKEDHLMTAMNIKLGPALKICAKINSLRE 320  black-legged tick
ABN11992      159 TNPWKWTVTDVCEFIKKLPEASDYVEEFSTHEIDGQALMLLKENHLISVMNMKLGLALKIVNKINALRE 227  hibiscus mealybug
XP_795462     788 RNPSSWSVENVAMFIRSLPGCAGYADEFQSQEIDGQALMLLKEDHLMTALSMKLGPALKIINKINTLKD 856  purple urchin
XP_002120523  234 SCPVRWSVEDVFTFIKSLPDSSQHAEDFRMQEIDGSALLLLHEEHLVCSMNLPLGPALKLCAHIDRLRE 302  Ciona intestinalis
XP_001629910  215 VEAAKWSIDQVADFIRSLQGCSEHADSFIAEEIDGQALMLLREEHMVVAMKMKLGPALKIVAKVDTMKR 283  starlet sea anemone

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