Conserved Protein Domain Family
SAM_liprin-alpha1,2,3,4_repeat1
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cd09562: SAM_liprin-alpha1,2,3,4_repeat1 
SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
SAM (sterile alpha motif) domain repeat 1 of liprin-alpha1,2,3,4 proteins is a protein-protein interaction domain. Liprin-alpha proteins contain three copies (repeats) of SAM domain. They may form heterodimers with liprin-beta proteins through their SAM domains. Liprins were originally identified as LAR (leukocyte common antigen-related) transmembrane protein-tyrosine phosphatase-interacting proteins. They participate in mammary gland development and in axon guidance; in particular, liprin-alpha is involved in formation of the presynaptic active zone.
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Statistics
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PSSM-Id: 188961
Aligned: 14 rows
Threshold Bit Score: 138.466
Created: 11-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O75334        895 FAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLT 965  human
Q21049        864 FALWNGPTVVAWLELWVGMPAWYVAACRANVKSGAIMSALSDQEIQKEIGISNPLHRLKLRLAIQEMVSLT 934  nematode
XP_002576489 1658 FAQWNGPTVVAWLELWVSMPAWYVAACRANVKSGAIMASLSEQEIQREIGISNPLHRLKLRLAIQEMVALT 1728 Schistosoma mansoni
NP_001093621  852 FAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLT 922  zebrafish
XP_002590212  764 FALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDQEIQREIGISNPLHRLKLRLAIQEMVSLT 834  Florida lancelet
XP_002120635  892 FAAWNGPTVVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIHEMISLT 962  Ciona intestinalis
NP_001088956  881 FAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLT 951  African clawed frog
XP_002400465  875 FALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVALT 945  black-legged tick
NP_609067     942 FALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLT 1012 fruit fly
ACE75733      114 FALWNGPTIVAWLELWVGMPAWYVAACHANVKSGAIMSALSNQEIQQEIGISNPLHRLKLRLAIQEMVNLT 184  medicinal leech
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