Conserved Protein Domain Family
SAM_ZCCH14
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cd09558: SAM_ZCCH14 
SAM domain of ZCCH14 subfamily
SAM (sterile alpha motif) domain of ZCCH14 (Zinc finger CCHC domain 14) protein subfamily (also known as BDG-29 or KIAA0579) is a putative RNA binding domain. Members of this group are believed to be involved in post-translational regulation during early embryogenesis.
Links
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Statistics
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PSSM-Id: 188957
Aligned: 4 rows
Threshold Bit Score: 137.139
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative RNA
Feature 1:putative RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on homology to related proteins.
  • Comment:Specificity of RNA binding relies on a shallow pocket of the SAM domain interacting with a guanosine loop base and on the SAM domain contacts to the unique backbone structure of the loop.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 # ######                            ## ##            
Q8VIG0    300 QPQEQNGILDWLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKFEsLTMGAKKKLKTQLELEKEKS 364  house mouse
Q8WYQ9    294 QTQEQNGILDWLRKLRLHKYYPVFKQLSMEKFLSLTEEDLNKFEsLTMGAKKKLKTQLELEKEKS 358  human
XP_414191 287 QTQEQNGILDWLRKLRLHKYYPVFKQLTMEKFLSLTEEDLNKFEsLTMGAKKKLKTQLELEKEKS 351  chicken
CAK04800  230 PSPEQNGILDWLRKLRLHKYYPVFKQLTMEEFLALTEEDLNKYD-LTQGAKKKLKTQLELQKEKL 293  zebrafish

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