Conserved Protein Domain Family
SAM_EPH-B3

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cd09553: SAM_EPH-B3 
SAM domain of EPH-B3 subfamily of tyrosine kinase receptors
SAM (sterile alpha motif) domain of EPH-B3 subfamily of receptor tyrosine kinases is a C-terminal potential protein-protein interaction domain. This domain is located in the cytoplasmic region of EPH-B3 receptors and appears to mediate cell-cell initiated signal transduction. EPH-B3 receptor protein kinase performs kinase-dependent and kinase-independent functions. It is known to be involved in thymus morphogenesis, in regulation of cell adhesion and migration. Also EphB3 controls cell positioning and ordered migration in the intestinal epithelium and plays a role in the regulation of adult retinal ganglion cell axon plasticity after optic nerve injury. In some experimental models overexpression of EphB3 enhances cell/cell contacts and suppresses colon tumor growth.
Statistics
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PSSM-Id: 188952
Aligned: 3 rows
Threshold Bit Score: 145.946
Created: 10-May-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative phosphorylation site [posttranslational modification site]
Evidence:
  • Comment:Highlighted tyrosine is a potential phosphoregulatory site and histidine is its bonding partner (phosphorylated upon activation by ephrin).
  • Citation:PMID 9886291

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         #                                #               
Q91735    898 PDYTTFPTVSDWLEAIKMGQYQENFLSAGFTSFHLVAQMTAEDLLRIGVTLAGHQKKLLNSVQDMRLQM 966  African clawed frog
Q07498    912 PDYTTFTTVGDWLDAIKMGRYKENFVNAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQM 980  chicken
P54753    922 PDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQM 990  human

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