2EAO


Conserved Protein Domain Family
SAM_EPH-B1
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cd09551: SAM_EPH-B1 
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SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
SAM (sterile alpha motif) domain of EPH-B1 subfamily of receptor tyrosine kinases is a C-terminal potential protein-protein interaction domain. This domain is located in the cytoplasmic region of EPH- B1 receptors. In human vascular endothelial cells it appears to mediate cell-cell initiated signal transduction via the binding of the adaptor protein GRB10 (growth factor) through its SH2 domain to a conserved tyrosine that is phosphorylated. EPH-B1 receptors play a role in neurogenesis, in particular in regulation of proliferation and migration of neural progenitors in the hippocampus and in corneal neovascularization; they are involved in converting the crossed retinal projection to ipsilateral retinal projection. They may be potential targets in angiogenesis-related disorders.
Links
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Statistics
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PSSM-Id: 188950
Aligned: 4 rows
Threshold Bit Score: 130.544
Created: 10-May-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:putative phosphorylation site [posttranslational modification site]
Evidence:
  • Comment:Highlighted tyrosine is a potential phosphoregulatory site and histidine is its bonding partner (phosphorylated upon activation by ephrin).
  • Citation:PMID 9886291
  • Citation:PMID 8798570
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         #                                #              
2EAO_A     17 PDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAGHQKKILNSIHSMRVQ 84   human
Q07494    908 PDFTAFTSVEDWLSAVKMSQYRDNFLSAGFTSLQLVAQMTSEDLLRIGVTLAGHQKKILNSIQSMRVQ 975  chicken
Q91571    909 PDISAFTSVDDWLSAIKMGQYRDNFLSSGFTSLQLVAQMTSEDLLRIGITLAGHQKKILNSIQSMRVQ 976  African clawed frog
CAG07681  809 PDFNTFSSVEDWLGAIKMSQYRDNFLNSGFTSLQLVAQMTSEDLLRIGVTLAGHQKKILSNVQSMRVQ 876  spotted green pufferfish

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