Conserved Protein Domain Family
SAM_KIF24-like
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cd09541: SAM_KIF24-like 
SAM domain of KIF24-like subfamily
SAM (sterile alpha motif) domain of KIF24 subfamily is a putative protein-protein interaction domain. This subfamily includes proteins related to human kinesin-like protein KIF24. SAM domain is located at the N-terminus followed by kinesin motor domain. Kinesins are proteins involved in a number of different cell processes including microtubule dynamics and axonal transport. Kinesins of this group belong to N-type; they drive microtubule plus end-directed transport. SAM apparently plays the role of adaptor or scaffold domain. In many cases SAM is known as a mediator of dimerization/oligomerization.
Links
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Statistics
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PSSM-Id: 188940
Aligned: 13 rows
Threshold Bit Score: 81.5748
Created: 19-Aug-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5T7B8          3 SWLYECLCEAELAQYYSHFTalglQKIDELAKITMKDYsk-lGVHDMNDRKRLFQLIKIIK 62   human
XP_002940612   40 LCLFECLCEADLQQYYPRFAavglQKIDELAQITMKDYsr-lGVERMEDRKRLFQLIQIIQ 99   western clawed frog
XP_424972       3 SCLFECLCEADLEKYYPHFAafglQKIDELAKISMKDYtk-lGVHDMNDRKRLFQLIRIIK 62   chicken
XP_002592262    3 NCLYECLREARLERYYPNFEsqglTMSEGLSELTMQDYsr-fGVEDMHDRKRLFQLIQVIK 62   Florida lancelet
XP_001781018   21 AVMARWLQSAGLQHLAAPLSaaavDHQLLPTLLMQQDYar-yGVQSLEDKQKLFRLIKTIN 80   Physcomitrella patens subsp. patens
Q6S004          6 DQLYNWLQLANLESFYPNFIkk-nVSCDSFLSFTMQDYgn-vGITSLQDRKKLFHLLQQLK 64   Dictyostelium discoideum
EES98755        3 DLVYQWLESANLQQYYPAFEqq-gITPQRFITITIQDYga-lGIQALPDKQKLFRLITTLK 61   Giardia intestinalis ATCC 50581
XP_828410       3 RQLRELLEQGGLSHTIQGFVdggvLTLQQLKQLTMQDYqs-vGVIVMTDRRKLFELIQYMK 62   Trypanosoma brucei TREU927
XP_783175       6 SLFEMCLKEAQLDHYSSSFQgggiGDLETLATLSMQEYns-yGVTSSQDKKQLFRLIHTLR 65   purple urchin
NP_188285      29 AVMARWLQSAGLQHLASPVAst-gNDQRHLPNLLMQGY----GAQTAEEKQRLFQLMRNLN 84   thale cress
XP_002947107    4 ALVVRGLEDAGLKRFIPAFAg---ISDQAFFGLMMSDYps-hGIVELEDKQKLFRLIKSIS 60   Volvox carteri f. nagariensis
EEH51427       28 GRVRGWLSRAGLHAYHEAFAr---TTERSFGALMMSDFas-hGVVDTADKQKLFRLIKTLN 84   Micromonas pusilla CCMP1545
XP_002679830    8 SVLFKYLEKASLDHYYSQLKlngvTSIEAIAQLSVQDVankiGVSNGGDRRKFFELIQVAK 68   Naegleria gruberi strain NEG-M
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