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SAM domain of SLP76 subfamily SAM (sterile alpha motif) domain of SLP76 (SH2 domain-containing leukocyte protein 76), also known as LCP2 (Lymphocyte cytosolic protein), subfamily is a protein-protein interaction domain. Proteins of this group have an N-terminal SAM domain, 3 phosphotyrosine motifs, a proline-rich region and a C-terminal SH2 domain. They are scaffold proteins involved in protein complex formation. The complexes play a role in T-cell receptor mediated signaling pathways such as integrin activation, cytoskeletal organization, MARK activation, and calcium flux. SAM domain deleted SLP76 knockin mice show a number of defects, including partially blocked thymocyte development, impaired positive and negative thymic selection and changes in T-cell receptor mediated signaling.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",