Conserved Protein Domain Family
SAM_ANKS6
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cd09518: SAM_ANKS6 
SAM domain of ANKS6 (or SamCystin) subfamily
SAM (sterile alpha motif) domain of ANKS6 (or SamCystin) subfamily is a potential protein-protein interaction domain. Proteins of this subfamily have N-terminal ankyrin repeats and a C-terminal SAM domain. They are able to form self-associated complexes and both (SAM and ANK) domains play a role in such interactions. Mutations in Anks6 gene are associated with polycystic kidney disease. They cause formation of renal cysts in rodent models. It was suggested that the ANKS6 protein can interact indirectly (through RNA and protein intermediates) with BICC1, another polycystic kidney disease-associated protein.
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Statistics
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PSSM-Id: 188917
Aligned: 7 rows
Threshold Bit Score: 131.536
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6GQX6       769 TITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLQELGIKTDGSRQQILAAISELNA 833  house mouse
Q68DC2       771 TITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNA 835  human
NP_001005928 641 TITDEDELSGILRKLSLEKYQPIFEEQEVDMEAFLTLTDGDLQELGIRTDGPRQQILAAISELNA 705  zebrafish
XP_419064    774 TITEDDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNA 838  chicken
NP_001123839 789 TITDEDELSAILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNA 853  western clawed frog
XP_785323    817 SISEEDELSNLLRKLSLEKYAPIFEEQEVDMEAFLALNDSDLKEMGIRHKEPRNQILTAITQMNS 881  purple urchin
XP_002124145 723 SLSEEDELSGILRKLSLENYHPIFEEQEINMDDFLTLTHGDLSELGITQELPRQQILQAIKQINN 787  Ciona intestinalis
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