2E8O


Conserved Protein Domain Family
SAM_HD
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cd09508: SAM_HD 
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SAM domain of HD-phosphohydrolase
SAM (sterile alpha motif) domain of SAM_HD subfamily proteins is a putative protein-protein interaction domain. Proteins of this group, additionally to the SAM domain, contain a HD hydrolase domain. Human SAM-HD1 is a nuclear protein involved in innate immune response and may act as a negative regulator of the cell-intrinsic antiviral response. Mutations in this gene lead to Aicardi-Goutieres syndrome (symptoms include cerebral atrophy, leukoencephalopathy, hepatosplenomegaly, and increased production of alpha-interferon).
Links
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Statistics
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PSSM-Id: 188907
Aligned: 9 rows
Threshold Bit Score: 84.6738
Created: 8-Mar-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E8O_A        26 DYKTWGPEQVCSFLRRGGFe-ePVLLKNIRENEITGALLPCLDESRFENLGVSSLGERKKLLSYIQRLVQI 95  human
Q60710        42 DLRTWEPEDVCSFLENRGFr-eKKVLDIFRDNKIAGSFLPFLDEDRLEDLGVSSLEERKKMIECIQQLSQS 111 house mouse
Q502K2        22 EFDRWDVEDTVAYLRGEGL---QEWAQIFKDNGITGAGLLCLTEAHLEKMGVSPLGARLHILHCLQKLSQI 89  zebrafish
Q6INN8        40 NYREWDVEEVCLFLASHGL---GELEVIFRENKIKGRILEYLTDSHLKDLQISSVALRLDLLSCLRMLCQN 107 African clawed frog
XP_001381585  39 DPQSWGPEQLCAFLNHQGFs-dPALLSRFRENKIRGSQLLHLDESLLENLGVRSSEDRQKLLDCVYKLNQS 108 gray short-tailed opossum
XP_002604957  33 DFREWTVHDVCNFLTENGQkddHDTVEVFKREEICGAVLPDITEERLEKMGFRTMGKRLLLLKLLERFKLV 103 Florida lancelet
NP_001026016  33 DPRLWDTERLCQHLSRNGVg-ePGLLRRFRESGVTGAMLLDLPACALRITHACLPDERLEVLACLNQLRQT 102 chicken
CAF95112      32 DFPQWGEEETCQYLRKEGF---GEWQEAFREREIDGARLRSLRDADLEQMGIRCPDERLRLLRSLRKLWQI 99  spotted green pufferfish
XP_784786     23 QWRSWTPEDVGRYFRGKGF---SEEGGIMTRGNISGDHLPQMTEERLEKIGVHTVGKRLSVLKIINTLPRN 90  purple urchin
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