SAM domain of diacylglycerol kinase delta and eta subunits
SAM (sterile alpha motif) domain of DGK-eta-delta subfamily proteins is a protein-protein interaction domain. Proteins of this subfamily are multidomain diacylglycerol kinases with a SAM domain located at the C-terminus. DGK proteins participate in signal transduction. They regulate the level of second messengers such as diacylglycerol and phosphatidic acid. The SAM domain of DGK proteins can form high molecular weight homooligomers through head-to-tail interactions as well as heterooligomers between the SAM domains of DGK delta and eta proteins. The oligomerization plays a role in the regulation of DGK intracellular localization.
Structure:3BQ7; human SAM/SAM complex of DGK delta1 formed by the end-helix (EH) surface of 3BQ7_A and the mid-loop (ML) surface of 3BQ7_B, contacts at 4A.
Comment:SAM domains of DGK delta1 proteins interact to each other in head-to-tail manner (ML surface interacts with EH surface).
Jiyao W et al.(2023). "The conserved domain database in 2023.",