2CU8


Conserved Protein Domain Family
LIM1_TLP

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cd09476: LIM1_TLP 
Click on image for an interactive view with Cn3D
The first LIM domain of thymus LIM protein (TLP)
The first LIM domain of thymus LIM protein (TLP): TLP is the distant member of the CRP family of proteins. TLP has two isomers (TLP-A and TLP-B) and sharing approximately 30% with each of the three other CRPs. Like CRP1, CRP2 and CRP3/MLP, TLP has two LIM domains, connected by a flexible linker region. Unlike the CRPs, TLP lacks the nuclear targeting signal (K/R-K/R-Y-G-P-K) and is localized solely in the cytoplasm. TLP is specifically expressed in the thymus in a subset of cortical epithelial cells. TLP has a role in development of normal thymus and in controlling the development and differentiation of thymic epithelial cells. LIM domains are 50-60 amino acids in size and share two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes.
Statistics
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PSSM-Id: 188860
Aligned: 6 rows
Threshold Bit Score: 101.195
Created: 30-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Structure:2CU8_A: Human TLP protein LIM1 domain binds Zn
  • Comment: The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #  #                 #  #  #  #                 #   # 
2CU8_A        12 CPKCDKTVYFAEKVSSLGKDWHKFCLKCERCSKTLTpGGHAEHDGKPFCHKPCY 65  human
XP_684430      5 CPRCDKTVFFAEKVSSLGKNWHRFCLKCERCSKILSpGGHAEHDGLPYCHKPCY 58  zebrafish
NP_001015811   5 CPRCRAPVYFAEKVSSLGKNWHRFCLKCELCNKILSaGGHAEHDGQPYCHKPCY 58  western clawed frog
AAK60525       5 CPRCQQPVYFAEKVSSLGKNWHRFCLKCERCHSILSpGGHAEHNGRPYCHKPCY 58  house mouse
Q6Q6R5         5 CPRCQQPVFFAEKVSSLGKNWHRFCLKCERCHSILSpGGHAEHNGRPYCHKPCY 58  human
NP_998662      5 CPKCEKTVYFAEKVSSLGKDWHKFCLKCERCSKTLTaGGHAEHDGKPYCHKPCY 58  zebrafish

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