Conserved Protein Domain Family
LIM_Mical_like_2

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cd09445: LIM_Mical_like_2 
This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
The LIM domain on proteins of unknown function: This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL)-like proteins. Known members of the Mical-like family includes single LIM domain containing proteins, Mical (molecule interacting with CasL), pollen specific protein SF3, Eplin, xin actin-binding repeat-containing protein 2 (XIRP2), and Ltd-1. The members of this family function mainly at the cytoskeleton and focal adhesions. They interact with transcription factors or other signaling molecules to play roles in muscle development, neuronal differentiation, cell growth, and mobility. As in other LIM domains, this domain family is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Statistics
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PSSM-Id: 188829
Aligned: 8 rows
Threshold Bit Score: 108.705
Created: 1-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #                     #  #  #  #                 #  # 
EFA08463      467 CRSCGKAVFQMEQIk----AEKAVWHKNCFRCTECNKQLnvDTYQSNEGSLYCKPHF 519  red flour beetle
XP_002405716    7 CKKCGTHVYPVERIi----AEKHFYHKNCFRCKECNKLLsvDGYMSHEAEIYCKIHF 59   black-legged tick
NP_001014703   80 CHQCKKPVYKMEEVilslkTATTIFHKTCLRCKDCGKHLkfDSYNVHDGSLYCSMHF 136  fruit fly
XP_002027588   83 CRQCGKPVYKMEEAilqfkKEKVIFHKICLRCRDCSKQLkpESYHVHNGNLFCTVHF 139  Drosophila persimilis
ACY70482       94 CRYCTKPVYKMEEVivqfkTDKGIYHKSCLRCQDCAKQLkfDNYQSHEGNLYCNVHF 150  Drosophila virilis
XP_001947503  122 CKSCEKTVYAMEQIk----AERQVWHKNCFRCTTCNKQLtlDIYSSHEGILYCKPHF 174  pea aphid
XP_002011458  149 CKLCSKPVYKMEEVivqfkSDKSIYHKFCLRCKDCGRQLkfDNYQSHEGDLYCNVHF 205  Drosophila mojavensis
EFN72461      770 CRSCGKVVFQMEQTk----AEGLVWHKNCFRCVQCGKQLnvDNYESHESTLYCKPHF 822  Camponotus floridanus

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