Conserved Protein Domain Family
LIM_Mical_like_1

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cd09444: LIM_Mical_like_1 
This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
The LIM domain on proteins of unknown function: This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins. Known members of the Mical-like family includes single LIM domain containing proteins, Mical (molecule interacting with CasL), pollen specific protein SF3, Eplin, xin actin-binding repeat-containing protein 2 (XIRP2), and Ltd-1. The members of this family function mainly at the cytoskeleton and focal adhesions. They interact with transcription factors or other signaling molecules to play roles in muscle development, neuronal differentiation, cell growth, and mobility. As in other LIM domains, this domain family is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Statistics
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PSSM-Id: 188828
Aligned: 14 rows
Threshold Bit Score: 115.585
Created: 22-Jul-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #  #                 #  #  #  #                   #  # 
XP_001378801  77 CAICKKHVHLVQRYLVDGKLYHRNCFRCKQCSSTLhsGAYKSTGEpgIFVCMNHH 131  gray short-tailed opossum
NP_001085831 188 CMICGKHVHLVQRHMADGKLYHRNCFKCKQCGRTLqaGEYKAGDGpgSFVCTNHH 242  African clawed frog
AAH47798     179 CSVCNQHVHLVQRHLVDGKLYHRNCFKCKECSTILlsGTYKAGKEpgTFICKTHT 233  zebrafish
Q8BGT6       165 CAACGQRVHLVQRYLAEGRLYHRHCFRCRQCSSTLvpGSYSSGPEegTFVCAERC 219  house mouse
XP_414767    180 CGICGNHVHLVQRHLVDGKLYHRNCFRCRECWNVLlpGSYKAGPEpgTFICTSHQ 234  chicken
XP_001513757 303 CAVCGRHVHLVQRHLVDGKLFHRNCFRCKQCSNTLhsGTYRPAEEpgSFLCINHH 357  platypus
NP_963879    237 CAVCGNHVHLVQRHLVDGKLYHRSCYKCSVCYGTLksGAYKLGSDtgSLVCTIHQ 291  zebrafish
CAF95266     171 CAACHEHVHLVQRFLADGKLYHRNCFRCSECHSTLlpGSYKLESSsgVLVCTHHV 225  spotted green pufferfish
CAL49355     174 CALCQQHVHLVQRYLVEGKLYHRQCFRCKECSSTLvpGAYRPGTDagTLVCTHHC 228  western clawed frog
Q8IY33       188 CGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSCTLhsGAYKATGEpgTFVCTSHL 242  human

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