Conserved Protein Domain Family
LIM1_UF1
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cd09397: LIM1_UF1 
LIM domain in proteins of unknown function
The first Lim domain of a LIM domain containing protein: The functions of the proteins are unknown. The members of this family contain two copies of LIM domain. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Links
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Statistics
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PSSM-Id: 188783
Aligned: 26 rows
Threshold Bit Score: 92.7105
Created: 7-May-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #                    #  #  #  #                   #  #  
XP_002494200 492 CRKCNSEItgKSIWSKdSLLSGRWHRHCFGCSVCETPFkksssqCYVFDDKPYCSRHFH 550 Pichia pastoris GS115
EEU45066     494 CKACKLAItgKSISSAdGRLTGKYHKACFVCTTCTQPFts--aeFYVLDDKPYCEHHYH 550 Nectria haematococca mpVI 77-13-4
XP_757810    683 CRKCHLIVekGAVKSSdGALRGVFHRSCFSCAACETPFkd--gsFYVYNHQPYCSRHYH 739 Ustilago maydis 521
EDP53765     588 CRGCGEAIlgKSVSSKdGRLTGRYHRECFVCCHCRSPFet--adFYVLNDRPYCAQHYH 644 Aspergillus fumigatus A1163
XP_569221    557 CRKCKLPIekSAVSSSdGQLKGKWHRACFTCTKCDRPFeg--ddFYVLGGKPWCQYHYH 613 Cryptococcus neoformans var. neoform...
CBI57743     582 CKGCNLPItgKSISSAdGRLTGRYHKACFVCFNCHQPFss--atFYVHQDRPYCERHYH 638 Sordaria macrospora
XP_002837523 629 CRGCGEAIvgKSISSAdGRLTGRYHKACFVCRDCHEPFqs--aeFYVLNNSPYCHRHYH 685 Tuber melanosporum Mel28
XP_001800487 578 CRGCSEPIvgKSVKDSsGRLTGRYHKHCFVCKTCSDPFpt--aeFYVYENSPYCERHYH 634 Phaeosphaeria nodorum SN15
XP_001910918 662 CKACGLPIkgKSISSAdGRLTGRYHKPCFVCSTCQEPFts--atFYVLNDRPYCEQHYH 718 Podospora anserina DSM 980
XP_003066742 550 CRGCGEIIvgKSVSSAdGRLTGRWHKACFVCYTCHSPFqt--adFYVLDNNPFCAQHYH 606 Coccidioides posadasii C735 delta SOWgp

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