Conserved Protein Domain Family
LIM1_Rga
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cd09394: LIM1_Rga 
The first LIM domain of Rga GTPase-Activating Proteins
The first LIM domain of Rga GTPase-Activating Proteins: The members of this family contain two tandem repeats of LIM domains and a Rho-type GTPase activating protein (RhoGap) domain. Rga activates GTPases during polarized morphogenesis. In yeast, a known regulating target of Rga is CDC42p, a small GTPase. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Links
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Statistics
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PSSM-Id: 188780
Aligned: 13 rows
Threshold Bit Score: 88.9567
Created: 19-Jul-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                     #  #  #  #                     #  # 
XP_454063      14 CVRCTNHItmgh----ayeLGGNRWHTHCFSCYKCDKPLscd--sdfLVLGTSDLICFECS 68   Kluyveromyces lactis NRRL Y-1140
XP_760011      33 CGGCGRLIdeesveegviqFATKLWHIECFRCAKCKNRVster-ddiLLLSDGHPICGECN 92   Ustilago maydis 521
EDK41131       18 CKRCGEPIfegh----ayeLGEDRWHIHCFKCSKCETSLgcn--snfLVLGNGNLICSNCS 72   Pichia guilliermondii ATCC 6260
EER40706       20 CQGCGEILeegk----afeLAGKRWHIDCFRCNTCGTFLdsd--anlLLLGDGSLICNNCT 74   Ajellomyces capsulatus H143
XP_002469370   10 CPGCKKSVvdeng-gvvvaFGQSFFHVDCFKCAKCGNQVtad--tnlLLLSDGSPICANCS 67   Postia placenta Mad-698-R
XP_002489501   54 CKKCGLVItegh----ayeLGEDRWHVECFSCSKCSKSLgcd--snfLVLGTGALVCSDCS 108  Pichia pastoris GS115
XP_500711      21 CKKCSKILeegr----ayeLGGNRWHVECFRCSSCDSLLdgd--tnlLVLGNGSLICANCS 75   Yarrowia lipolytica CLIB122
XP_448668      19 CVKCKEPIttgh----ayeLGYDRWHIECFACHKCDRLLtcd--sdfLVLGTGALICFDCS 73   Candida glabrata CBS 138
NP_983607      27 CTRCTLAIttgh----ayeLGGDRWHTHCFTCYKCDKELtcd--sdfLVLGTGTLICFACS 81   Ashbya gossypii ATCC 10895
CAY86414       13 CVRCKEFIttgh----ayeLGCDRWHTHCFACYKCEKPLsce--sdfLVLGTGALICFDCS 67   Saccharomyces cerevisiae EC1118
XP_001645164   13 CASCKEDIiddn----yfkIGEDKWHIHCFKCYKCEKKLskdssflrMNNSKNSLICSDCS 69   Vanderwaltozyma polyspora DSM 70294
CAY78881       13 CVRCNKSIassq----vyeLESKKWHDQCFTCYKCDKKLnad--sdfLVLDIGTLICYDCS 67   Saccharomyces cerevisiae EC1118
XP_001387915   27 CKKCNQPIyegh----ayeLGDDRWHLDCFKCSKCDSSLgcn--snfLVLGNGNLICSNCS 81   Pichia stipitis CBS 6054

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